This competing renewal application requests continuation of support for years 31-35 for training in Molecular and Cell Biology and Biochemistry for an exceptional cohort of predoctoral students in the Brown University Graduate Program in Molecular Biology, Cell Biology and Biochemistry (MCB). The MCB Graduate Program is an interdepartmental interdisciplinary program, and students are admitted on the basis of both their research and academic potential. Trainees will be chosen during their first or second year of graduate study at Brown from the ~60 students in the MCB graduate program, based their potential for success in research. Funds are requested to support 8 trainees during year 1, with growth to 10 trainees by year 5. Our goals are to provide students with a strong academic and experimental foundation and to equip them with the skills necessary to succeed in multiple areas of modern biology. We offer a carefully planned program leading to broad and deep knowledge in diverse but interrelated experimental fields, spanning the areas of biochemistry and macromolecular structure, molecular biology and genetics, cell biology, developmental biology, genomics, proteomics and computational biology. Our program features balanced and clearly stated requirements, individualized and regular advising, strong courses and opportunities for public speaking. Research opportunities range from basic science to studies of specific diseases and disease-causing agents. The 53 faculty trainers are drawn from 13 Departments, including 9 Departments at Brown University and 4 Clinical Departments within the Medical School, as well as from the Marine Biological Laboratory at Woods Hole. The expansion of the training faculty through both Brown University faculty hiring initiatives as well as by further development of interdepartmental connections and academic initiatives have markedly increased the multidisciplinary research and collaborative opportunities for students and faculty.

Public Health Relevance

Solving the complex problems in human health and modern biology will require the development of interdisciplinary approaches by the next generation of experimental biologists. Accordingly, this program is designed to train students at the interfaces of scientific disciplines.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM007601-34
Application #
8500316
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Gindhart, Joseph G
Project Start
1979-09-01
Project End
2015-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
34
Fiscal Year
2013
Total Cost
$357,236
Indirect Cost
$16,980
Name
Brown University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
001785542
City
Providence
State
RI
Country
United States
Zip Code
02912
Kennedy, Erin E; Caffrey, Paul J; Delaney, Sarah (2018) Initiating base excision repair in chromatin. DNA Repair (Amst) :
Borensztejn, Antoine; Mascaro, Alexandra; Wharton, Kristi A (2018) JAK/STAT signaling prevents excessive apoptosis to ensure maintenance of the interfollicular stalk critical for Drosophila oogenesis. Dev Biol 438:1-9
Wang, Ailin; Conicella, Alexander E; Schmidt, Hermann Broder et al. (2018) A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing. EMBO J 37:
Monaghan, Sean F; Banerjee, Debasree; Chung, Chun-Shiang et al. (2018) Changes in the process of alternative RNA splicing results in soluble B and T lymphocyte attenuator with biological and clinical implications in critical illness. Mol Med 24:32
Ryan, Veronica H; Dignon, Gregory L; Zerze, Gül H et al. (2018) Mechanistic View of hnRNPA2 Low-Complexity Domain Structure, Interactions, and Phase Separation Altered by Mutation and Arginine Methylation. Mol Cell 69:465-479.e7
Beekman, Chapman N; Meckler, Lauren; Kim, Eleanor et al. (2018) Galleria mellonella as an insect model for P. destructans, the cause of White-nose Syndrome in bats. PLoS One 13:e0201915
Fresques, Tara M; Wessel, Gary M (2018) Nodal induces sequential restriction of germ cell factors during primordial germ cell specification. Development 145:
Jeschonek, Samantha P; Mowry, Kimberly L (2018) Whole-Mount Immunofluorescence for Visualizing Endogenous Protein and Injected RNA in Xenopus Oocytes. Cold Spring Harb Protoc 2018:pdb.prot097022
Perry, Jenna A; Sinclair-Davis, Amy N; McAllaster, Michael R et al. (2018) TbSmee1 regulates hook complex morphology and the rate of flagellar pocket uptake in Trypanosoma brucei. Mol Microbiol 107:344-362
Fratta, Pietro; Sivakumar, Prasanth; Humphrey, Jack et al. (2018) Mice with endogenous TDP-43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis. EMBO J 37:

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