This application requests resources to support 42 trainees per year through the Medical Scientist Training Program (MSTP) at the University of California, San Francisco (UCSF). The MSTP has the goal of training the next generation of physician-investigators by offering a rigorous, integrated, and supportive educational experience leading to both M.D. and Ph.D. degrees. The UCSF MSTP offers the combination of an outstanding public medical school with an innovative curriculum, committed and renowned faculty, and a collection of premier graduate training programs. The program is currently in its 33rd year of continuous NIH support. From its inception, the guiding principles have been: (1) selecting outstanding students who are committed to careers as physician-investigators and who have the academic ability and interpersonal skills to excel in medicine and science;(2) offering the best possible training leading to combined M.D. and Ph.D. degrees without compromising the quality of training for either degree;and, (3) actively engaging the UCSF School of Medicine (SOM) and Graduate Programs to optimize the training path of each student and to encourage efficient completion of both degrees. During the current period of T32 support, our MSTP has continued to attract and train exceptional students who have a remarkable record of success. The leaders of the SOM have demonstrated an extraordinary level of commitment to the program, which has increased in size from 67 to 87 trainees. New activities to enhance and optimize the training of students have been added during the current period of support. Our trainees have formed a strong community that has engaged the faculty to enhance the training environment at UCSF. The achievements of our students and their subsequent track records underscore the value of this combined degree program. This application is directly relevant to the mission of the NIGMS and NIH as it requests funds to support mentored career development for the next generation of physician-scientists. This MSTP represents an investment in the future of our nation's health as the researchers who are trained through this award will be optimally prepared to harness discovery-based research strategies to attack urgent problems in human health with the goal of developing and implement innovative new treatments.
Attacking complex diseases such as cancer, arthritis, and Alzheimer's dementia will require a new generation of researchers who are both outstanding physicians and skilled scientists who understand how to harness new technologies to advance human health. This application requests continuing support for the Medical Scientist Training Program at the University of California, San Francisco, which is achieving this goal by offering a rigorous, integrated, and supportive program that results in graduates who hold both M.D. and Ph.D. degrees.
|Jost, Marco; Chen, Yuwen; Gilbert, Luke A et al. (2017) Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent. Mol Cell 68:210-223.e6|
|Nissen, Kelly E; Homer, Christina M; Ryan, Colm J et al. (2017) The histone variant H2A.Z promotes splicing of weak introns. Genes Dev 31:688-701|
|Theodoris, Christina V; Mourkioti, Foteini; Huang, Yu et al. (2017) Long telomeres protect against age-dependent cardiac disease caused by NOTCH1 haploinsufficiency. J Clin Invest 127:1683-1688|
|Ye, Julia; Jin, Hu; Pankov, Aleksandr et al. (2017) NF45 and NF90/NF110 coordinately regulate ESC pluripotency and differentiation. RNA 23:1270-1284|
|Javaid, Abdul Q; Ashouri, Hazar; Dorier, Alexis et al. (2017) Quantifying and Reducing Motion Artifacts in Wearable Seismocardiogram Measurements During Walking to Assess Left Ventricular Health. IEEE Trans Biomed Eng 64:1277-1286|
|Chang, Ryan; Faleo, Gaetano; Russ, Holger A et al. (2017) Nanoporous Immunoprotective Device for Stem-Cell-Derived ?-Cell Replacement Therapy. ACS Nano 11:7747-7757|
|Reed, Darien E; Shokat, Kevan M (2017) INPP4B and PTEN Loss Leads to PI-3,4-P2 Accumulation and Inhibition of PI3K in TNBC. Mol Cancer Res 15:765-775|
|Montoya, Misty M; Maul, Julia; Singh, Priti B et al. (2017) A Distinct Inhibitory Function for miR-18a in Th17 Cell Differentiation. J Immunol 199:559-569|
|Richardson, Eugene T; Barrie, Mohamed Bailor; Nutt, Cameron T et al. (2017) The Ebola suspect's dilemma. Lancet Glob Health 5:e254-e256|
|Yu, Jai Y; Kay, Kenneth; Liu, Daniel F et al. (2017) Distinct hippocampal-cortical memory representations for experiences associated with movement versus immobility. Elife 6:|
Showing the most recent 10 out of 229 publications