This is a continuing application for a Ph.D. (only) program in the Pharmacological Sciences. Graduate student trainees from Vanderbilt University or Meharry Medical College may be supported for up to two years of graduate training, generally years 2 and 3 of training. The first year of training in biomedical sciences at Vanderbilt University Medical Center is Interdisciplinary, and involves participation in an academic year long core curriculum. Students who select preceptors in the Pharmacological Sciences Training Program in May of their first year then begin the required course work for this graduate program. Program specific curriculum includes: Systems, Targets, and Drug Action (includes in vivo physiology, drug disposition, and principles of drug action);Receptors and Signal Transduction;Scientific Communications;and Biostatistics. In addition, students take at least six additional hours of elective courses to accommodate individual interests and needs. The curriculum for Meharry trainees is similar and cross registration agreements between Vanderbilt and Meharry results in Meharry trainees completing at least some of the above courses with Vanderbilt trainees. Research opportunities are available in several areas at both institutions: Receptor Mechanisms and Signal Transduction, Molecular mechanisms for Cellular Regulation, Neuropharmacology, Cardiovascular Pharmacology, Pharmacology of Arachidonic Acid Metabolites, and Drug Disposition and Pharmacokinetics. Course work is complemented by other important didactic experiences: weekly Journal Club;a student-invited annual Pharmacology Forum;an annual Department of Pharmacology Retreat for presenting upcoming research goals;and exchange programs between Vanderbilt and Meharry Medical College to strengthen the broad-based education of our students as well as to foster the careers of under-represented minorities in research. The training environment is further strengthened by emerging partnerships with the Lipscomb College of Pharmacy, the ability of trainees to participate in a Howard Hughes Medical Institute-funded Program in Molecular Medicine, and the presence of a highly successful, in-house Drug Discovery Program. Comprehensive qualifying examinations and defense of the dissertation proposal precedes dissertation research. After admission to candidacy for degree, dissertation committee meetings occur frequently to facilitate mentoring. The breadth of interest of the faculty, their international recognition and success in acquiring extramural peer-reviewed support, their understanding of the scientific process and an emphasis on scientific integrity make our program an outstanding environment for the training of independent scientists in the area of pharmacological sciences.

Public Health Relevance

Students are funded to provide training in the discipline of Pharmacology;the science of drug development and testing. Training includes coursework and original research in a laboratory. Scientists trained in this area perform important jobs in drug development in universities and industries, product safety, and regulatory affairs.

National Institute of Health (NIH)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Program Officer
Okita, Richard T
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Vanderbilt University Medical Center
Schools of Medicine
United States
Zip Code
Bruntz, Ronald C; Lindsley, Craig W; Brown, H Alex (2014) Phospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancer. Pharmacol Rev 66:1033-79
Jacobson, Richard; Mignemi, Nicholas; Rose, Kristie et al. (2014) The hyperglycemic byproduct methylglyoxal impairs anticoagulant activity through covalent adduction of antithrombin III. Thromb Res 134:1350-7
Chen, Qiuyan; Zhuo, Ya; Kim, Miyeon et al. (2014) Self-association of arrestin family members. Handb Exp Pharmacol 219:205-23
Tanwar, Vineeta; Bylund, Jeffery B; Hu, Jianyong et al. (2014) Gremlin 2 promotes differentiation of embryonic stem cells to atrial fate by activation of the JNK signaling pathway. Stem Cells 32:1774-88
Betke, Katherine M; Rose, Kristie L; Friedman, David B et al. (2014) Differential localization of G protein ?? subunits. Biochemistry 53:2329-43
Prosser, R A; Stowie, A; Amicarelli, M et al. (2014) Cocaine modulates mammalian circadian clock timing by decreasing serotonin transport in the SCN. Neuroscience 275:184-93
Wenthur, Cody J; Gentry, Patrick R; Mathews, Thomas P et al. (2014) Drugs for allosteric sites on receptors. Annu Rev Pharmacol Toxicol 54:165-84
Ramirez, Claudia E; Shuey, Megan M; Milne, Ginger L et al. (2014) Arg287Gln variant of EPHX2 and epoxyeicosatrienoic acids are associated with insulin sensitivity in humans. Prostaglandins Other Lipid Mediat 113-115:38-44
Ho, Karen W; Lambert, Wendi S; Calkins, David J (2014) Activation of the TRPV1 cation channel contributes to stress-induced astrocyte migration. Glia 62:1435-51
Bruntz, Ronald C; Taylor, Harry E; Lindsley, Craig W et al. (2014) Phospholipase D2 mediates survival signaling through direct regulation of Akt in glioblastoma cells. J Biol Chem 289:600-16

Showing the most recent 10 out of 107 publications