The Tri-Institutional MD-PhD Program is a joint undertaking of Weill Cornell Medical College (WCMC), The Rockefeller University (RU), and the Sloan-Kettering Institute for Cancer Research (SKI). Its mission is to train biomedical investigators who: on the one hand, have advanced understanding of biomedical science and a mastery of contemporary research skills, which will allow them to undertake fundamental studies to elucidate basic biological processes pertaining to human disease;and, on the other hand, are well grounded in human biology, pathobiology and clinical medicine, which will equip them to transfer advances in basic research to the understanding, prevention, and treatment of human disease. The three institutions operate three graduate schools: Weill Cornell Graduate School of Medical Sciences (WCGS), a joint undertaking between WCMC and SKI;the David Rockefeller Graduate School at RU;and the Gerstner Graduate School of Biomedical Sciences (GSK) at SKI. The Tri-Institutional MD-PhD Program was formed in 1991, when two independent MD-PhD Programs, the WCMC-RU Program and the WCMC-WCGS Program, were joined to form the present program. GSK became part of the Program in 2009. MSTP trainees complete all the requirements for the MD degree at WMC. They will get their PhD training in research laboratories in the three research institutions and receive their PhD degree from GSK, RU or WCGS. Accepted trainees arrive in early July before the start of medical school. During the first two years in the Program they complete their medical school course, take two graduate level courses designed for MD-PhD students, and complete three research rotations (in three different laboratories) before they settle into their thesis laboratory. When te students choose a research laboratory they enroll in the graduate school with which their thesis mentor is associated. The graduate course and thesis requirements are comparable for all MD-PhD students, irrespective of the graduate school in which they are matriculated-and the students can cross register and take courses for credit in any of the graduate schools. At the end of their research training, after they have defended their thesis, the students return to complete their clinical training at WMC. The present application requests funds to continue MD-PhD training at the three institutions beyond Year 40 (the predecessor WCMC-RU Program was formed in 1972;it received NIH funding in 1974). In its current iteration, the Program brings together faculty in more than 270 independent research laboratories. 317 MD- PhDs have graduated from the Tri-Institutional MD-PhD Program and its predecessors;currently there are 108 students in the Program. The current trainees come from 54 undergraduate schools. Their average GPA is 3.75, the combined MCAT score is 35.1. 94% of the graduates pursue post-graduate clinical training;of the 231 graduates who have completed their training, 202 (87%) have appointments in medical schools, research institutes or biotech/pharma.

Public Health Relevance

The increasing pace at which biomedical research advances increases, means that there is a greater need than ever for physicians who have received rigorous training and thus are able to work at important problems at the intersection between clinical medicine and laboratory science and thereby contribute toward improving health and enhancing the quality of life by reducing disability and death from disease. The goal of the Weill Cornell/Rockefeller/Sloan- Kettering Tri-Institutional Medical Scientist Training Program is to identify, train and mentor a diverse group of outstanding men and women to become the future leaders in biomedical research and patient care as scientists, educators and clinicians.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
2T32GM007739-36
Application #
8551131
Study Section
(TWD)
Program Officer
Preusch, Peter
Project Start
1979-07-01
Project End
2019-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
36
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Weill Medical College of Cornell University
Department
Administration
Type
Schools of Medicine
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10065
Sendoel, Ataman; Dunn, Joshua G; Rodriguez, Edwin H et al. (2017) Translation from unconventional 5' start sites drives tumour initiation. Nature 541:494-499
Lewis, Brittany B; Carter, Rebecca A; Ling, Lilan et al. (2017) Pathogenicity Locus, Core Genome, and Accessory Gene Contributions to Clostridium difficile Virulence. MBio 8:
Levine, Andrew G; Hemmers, Saskia; Baptista, Antonio P et al. (2017) Suppression of lethal autoimmunity by regulatory T cells with a single TCR specificity. J Exp Med 214:609-622
Han, Teng; Schatoff, Emma M; Murphy, Charles et al. (2017) R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine. Nat Commun 8:15945
Lv, Zongyang; Rickman, Kimberly A; Yuan, Lingmin et al. (2017) S. pombe Uba1-Ubc15 Structure Reveals a Novel Regulatory Mechanism of Ubiquitin E2 Activity. Mol Cell 65:699-714.e6
Levine, Andrew G; Medoza, Alejandra; Hemmers, Saskia et al. (2017) Stability and function of regulatory T cells expressing the transcription factor T-bet. Nature 546:421-425
Xue, Yaohua; Martelotto, Luciano; Baslan, Timour et al. (2017) An approach to suppress the evolution of resistance in BRAFV600E-mutant cancer. Nat Med 23:929-937
Weinberg, Daniel N; Allis, C David; Lu, Chao (2017) Oncogenic Mechanisms of Histone H3 Mutations. Cold Spring Harb Perspect Med 7:
Soliman, M A; Aboharb, F; Zeltner, N et al. (2017) Pluripotent stem cells in neuropsychiatric disorders. Mol Psychiatry 22:1241-1249
Nirschl, Christopher J; Suárez-Fariñas, Mayte; Izar, Benjamin et al. (2017) IFN?-Dependent Tissue-Immune Homeostasis Is Co-opted in the Tumor Microenvironment. Cell 170:127-141.e15

Showing the most recent 10 out of 481 publications