This proposal seeks continued and increased support for graduate training in genetics and genomics in the Duke University Program in Genetics and Genomics, a unique degree granting program which currently encompasses 102 faculty and 82 students and serves as bridge between basic and clinical departments in the School of Medicine and the College of Arts and Sciences. This includes faculty and students in the Departments of Biochemistry, Cell Biology, Immunology, Medicine, Microbiology and Molecular Genetics (MGM), Pathology, Pediatrics, Pharmacology and Cancer Biology, and Radiation Oncology in the Medical Center and from the department of Biology and Chemistry in the School of Arts and Sciences. Research interests span traditional and molecular genetics, model systems (bacteria, yeast, drosophila, nematode, and zebra fish), plant biology, human genetics, developmental biology, population genetics and genome sciences. Students apply directly to the program, most from undergraduate programs in the biological or physical sciences. During their first year, students attend courses, rotate in labs and meet with the first year advisory committee. At the conclusion of the first year, students choose a lab and thesis advisor, and ultimately receive their degree via the program or host department. Duke University established the Institute for Genome Sciences and Policy (IGSP) in 2002 and close links have been forged between the genetics training program and both the IGSP and its Director, Hunt Willard. The genetics program has been expanded to include both genome sciences in a joint program that is now called the Duke University Program in Genetics and Genomics (UPGG). The program is administered by the Director (Joe Heitman), Co-director (Doug Marchuk), Director of Graduate Studies (Mohamed Noor), Admissions Director (Mike Hauser), IGSP Director (Hunt Willard), and the Executive Committee. Currently the NIH provides support for 10 new students per year and Duke University via the Deans support five new students per year. Here we seek to expand the NIH supported portion of the training grant to a total of 12 new students per year.

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National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
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National Institute of General Medical Sciences Initial Review Group (BRT)
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Haynes, Susan R
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Duke University
Schools of Medicine
United States
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Kaplan, Rebecca E W; Baugh, L Ryan (2016) L1 arrest, daf-16/FoxO and nonautonomous control of post-embryonic development. Worm 5:e1175196
Rinehart, Matthew T; Park, Han Sang; Walzer, Katelyn A et al. (2016) Hemoglobin consumption by P. falciparum in individual erythrocytes imaged via quantitative phase spectroscopy. Sci Rep 6:24461
Vockley, Christopher M; D'Ippolito, Anthony M; McDowell, Ian C et al. (2016) Direct GR Binding Sites Potentiate Clusters of TF Binding across the Human Genome. Cell 166:1269-1281.e19
Wagner, Maggie R; Lundberg, Derek S; Del Rio, Tijana G et al. (2016) Host genotype and age shape the leaf and root microbiomes of a wild perennial plant. Nat Commun 7:12151
Black, Joshua B; Adler, Andrew F; Wang, Hong-Gang et al. (2016) Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells. Cell Stem Cell 19:406-14
Lin, Kevin H; Winter, Peter S; Xie, Abigail et al. (2016) Targeting MCL-1/BCL-XL Forestalls the Acquisition of Resistance to ABT-199 in Acute Myeloid Leukemia. Sci Rep 6:27696
Healy, Jane A; Nugent, Adrienne; Rempel, Rachel E et al. (2016) GNA13 loss in germinal center B cells leads to impaired apoptosis and promotes lymphoma in vivo. Blood 127:2723-31
Henderson, Morgan L; Kreuzer, Kenneth N (2015) Functions that Protect Escherichia coli from Tightly Bound DNA-Protein Complexes Created by Mutant EcoRII Methyltransferase. PLoS One 10:e0128092
Dey, Sandeepa; Chamero, Pablo; Pru, James K et al. (2015) Cyclic Regulation of Sensory Perception by a Female Hormone Alters Behavior. Cell 161:1334-44
Lin, Yi-Tzu; Capel, Blanche (2015) Cell fate commitment during mammalian sex determination. Curr Opin Genet Dev 32:144-52

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