Abstract

The aim of this predoctoral training program is to train scientists to conduct research and prepare for careers in modern molecular genetics and allied areas. Graduates of our program receive a multi-faceted training in genetics and biochemistry and are well equipped to tackle problems relevant to a broad range of diseases. The program has two broad intellectual facets centered on molecular genetics: the first is understanding the fundamentals of genetics itself (recombination, mutation, gene expression, etc.); the second is understanding how the tools of genetics (isolation of mutants, construction of gene maps, etc.) are used to address problems. These two goals are accomplished through coursework, an extensive seminar program, and research. The features of our training program that are especially attractive to prospective students are the following: (a) a wide choice of laboratories for thesis research, (b) a laboratory rotation system, (c) an excellent set of courses, (d) a tutorial in how to present a seminar, (e) a highly cooperative spirit at UCSF, and (f) an awareness that graduate training is important to the faculty at UCSF.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM007810-21
Application #
6150824
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Rhoades, Marcus M
Project Start
1979-07-01
Project End
2001-06-30
Budget Start
2000-07-01
Budget End
2001-06-30
Support Year
21
Fiscal Year
2000
Total Cost
$223,478
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Biochemistry
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143

  Publications

Eichel, Kelsie; von Zastrow, Mark (2018) Subcellular Organization of GPCR Signaling. Trends Pharmacol Sci 39:200-208
Laurie, Matthew T; White, Corin V; Retallack, Hanna et al. (2018) Functional Assessment of 2,177 U.S. and International Drugs Identifies the Quinoline Nitroxoline as a Potent Amoebicidal Agent against the Pathogen Balamuthia mandrillaris. MBio 9:
Faust, Tyler B; Li, Yang; Bacon, Curtis W et al. (2018) The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation. Elife 7:
Zhou, Coral Y; Johnson, Stephanie L; Lee, Laura J et al. (2018) The Yeast INO80 Complex Operates as a Tunable DNA Length-Sensitive Switch to Regulate Nucleosome Sliding. Mol Cell 69:677-688.e9
Hrit, Joel; Goodrich, Leeanne; Li, Cheng et al. (2018) OGT binds a conserved C-terminal domain of TET1 to regulate TET1 activity and function in development. Elife 7:
Genuth, Miriam A; Allen, Christopher D C; Mikawa, Takashi et al. (2018) Chick cranial neural crest cells use progressive polarity refinement, not contact inhibition of locomotion, to guide their migration. Dev Biol :
Seller, Charles A; O'Farrell, Patrick H (2018) Rif1 prolongs the embryonic S phase at the Drosophila mid-blastula transition. PLoS Biol 16:e2005687
Elnatan, Daniel; Agard, David A (2018) Calcium binding to a remote site can replace magnesium as cofactor for mitochondrial Hsp90 (TRAP1) ATPase activity. J Biol Chem 293:13717-13724
Burke, Jordan E; Longhurst, Adam D; Merkurjev, Daria et al. (2018) Spliceosome Profiling Visualizes Operations of a Dynamic RNP at Nucleotide Resolution. Cell 173:1014-1030.e17
Liang, Samantha I; van Lengerich, Bettina; Eichel, Kelsie et al. (2018) Phosphorylated EGFR Dimers Are Not Sufficient to Activate Ras. Cell Rep 22:2593-2600

Showing the most recent 10 out of 102 publications