The aim of this predoctoral training program in Cell Biology, Genetics, and Biochemistry is to train scientists to carry out the biomedical research of the future. We equip trainees with an integrated perspective on biological problems as well as broad expertise in a variety of experimental approaches. This training program brings together 95 faculty who are studying central problems in cell biology, genetics, and biochemistry, including regulation of the cell division cycle, signal transduction, chromosome structure, protein trafficking, cytoskeletal organization, protein and nucleic acid folding and structure, DNA replication, RNA splicing, transcriptional control, infectious disease, and various problems in molecular evolution. These studies use the tools of cell biology, genetics and biochemistry to exploit a wide range of systems, including bacteria, yeast, nematodes, zebrafish, Drosophila and humans. The goals of the combined program are accomplished through coursework, Ph.D. thesis research, and a variety of other activities. The features of our training program that are especially attractive to incoming students are: (a) a large number of active, excellent laboratories from which students can choose for their thesis research;(b) a laboratory rotation system that provides meaningful research experience in at least three different laboratories;(c) an excellent set of courses that enables students with little prior training in cell biology, genetics, or biochemistry to acquire a solid foundation in these areas;(d) one-on-one training with faculty members to sharpen public presentation skills;(e) a highly collegial, interactive, and collaborative atmosphere;(f) a high faculty to student ratio;and (g) the high level of importance placed by the UCSF faculty on training graduate students.
Two aspects of the training program are relevant to public health. First, by exposing students to first rate research in many different areas and disciplines, students acquire the expertise and confidence to carry on in a variety of capacities, not limited to those of the research lab or lecture hall. Students who have graduated from the program not only populate many departments throughout the country, but also participate in a variety of public policy roles related to public health. Second, all of the research projects have the potential to improve the understanding and treatment of human health problems, ranging from cancer to aging.
|Hernday, Aaron D; Lohse, Matthew B; Nobile, Clarissa J et al. (2016) Ssn6 Defines a New Level of Regulation of White-Opaque Switching in Candida albicans and Is Required For the Stochasticity of the Switch. MBio 7:e01565-15|
|Kamiyama, Daichi; Sekine, Sayaka; Barsi-Rhyne, Benjamin et al. (2016) Versatile protein tagging in cells with split fluorescent protein. Nat Commun 7:11046|
|Ahyong, Vida; Sheridan, Christine M; Leon, Kristoffer E et al. (2016) Identification of Plasmodium falciparum specific translation inhibitors from the MMV Malaria Box using a high throughput in vitro translation screen. Malar J 15:173|
|Eichel, K; JulliÃ©, D; von Zastrow, M (2016) Î²-Arrestin drives MAP kinase signalling from clathrin-coated structures after GPCR dissociation. Nat Cell Biol 18:303-10|
|Jay, Kyle A; Smith, Dana L; Blackburn, Elizabeth H (2016) Early Loss of Telomerase Action in Yeast Creates a Dependence on the DNA Damage Response Adaptor Proteins. Mol Cell Biol 36:1908-19|
|Hsiao, Jennifer Y; Goins, Lauren M; Petek, Natalie A et al. (2015) Arp2/3 complex and cofilin modulate binding of tropomyosin to branched actin networks. Curr Biol 25:1573-82|
|Roberson, Elle C; Dowdle, William E; Ozanturk, Aysegul et al. (2015) TMEM231, mutated in orofaciodigital and Meckel syndromes, organizes the ciliary transition zone. J Cell Biol 209:129-42|
|McMahon, Mary; Contreras, Adrian; Ruggero, Davide (2015) Small RNAs with big implications: new insights into H/ACA snoRNA function and their role in human disease. Wiley Interdiscip Rev RNA 6:173-89|
|Cerchiari, Alec; Garbe, James C; Todhunter, Michael E et al. (2015) Formation of spatially and geometrically controlled three-dimensional tissues in soft gels by sacrificial micromolding. Tissue Eng Part C Methods 21:541-7|
|Jones Jr, Stephen K; Clarke, Starlynn C; Craik, Charles S et al. (2015) Evolutionary Selection on Barrier Activity: Bar1 Is an Aspartyl Protease with Novel Substrate Specificity. MBio 6:e01604-15|
Showing the most recent 10 out of 62 publications