The Johns Hopkins Predoctoral Training Program in Human Genetics (JHHG) has grown steadily since its inception in 1980 in parallel to the spectacular growth of genetics and genomics and their application to medicine over the last three decades. Similarly, the Johns Hopkins School of Medicine continues to make commitments to human genetics as evidenced by the establishment of the McKusick-Nathans Institute of Genetic Medicine in 1999, provision of state of the art research space in 2004 and the introduction in 2009 of a new medical school curriculum, The Genes to Society curriculum, that has genetics and genetic-thinking as an organizing principle. The overall objective of the JHHG is to provide our students with a strong foundation in basic science by exposure to a rigorous graduate education in genetics, genomics, molecular biology, cell biology and biochemistry plus a core of medically-related courses selected to provide knowledge of human biology in health and disease. Through seminars, laboratory rotations and thesis work, our students are also exposed to a wide variety of modern research technologies relevant to human genetics and learn the basic skills necessary to become an independent investigator. The research activities of the 63 JHHG preceptors are diverse and include human and model organism genetics and genomics, developmental genetics, identification and analysis of genes and genetic variants responsible for human monogenic disorders and complex traits, molecular cytogenetic, quantitative genetics, gene therapy, oncogenetics, stem cell genetics and studies of the ethical and societal consequences of the genetic revolution. This broad spectrum of research activities in human genetics provides virtually unlimited opportunities for our students to work on projects appealing to their individual interests. The ultimate goal of our program is to produce independent investigators who are well- versed in human biology in health and disease and in all aspects of human genetics and genomics. Equipped wit this education, our students are well prepared to answer important basic science questions and to translate this information into medical advances. The success of our graduates, who obtain postdoctoral positions in top laboratories and go on to productive academic careers in top universities, strongly supports this conclusion.
Advances in human genetics and genomics are being made at an astounding rate while their application to medicine is proceeding at a much slower pace. The Johns Hopkins Predoctoral Training Program in Human Genetics aims to provide highly motivated and capable students with knowledge and experimental tools that will enable them to answer important questions at the interface between genetics and medicine. Ultimately, our trainees will play an important role in delivering the promise of genetics to human health.
|Park, J T; Johnson, N; Liu, S et al. (2015) Differential in vivo tumorigenicity of diverse KRAS mutations in vertebrate pancreas: A comprehensive survey. Oncogene 34:2801-6|
|Huang, Tai-Chung; Cutler, Jevon; Bharne, Shubhada et al. (2015) Integrated analysis of CRLF2 signaling in acute lymphoblastic leukemia identifies Polo-like kinase 1 as a potential therapeutic target. Leuk Lymphoma 56:1524-7|
|Zeitels, Lauren R; Acharya, Asha; Shi, Guanglu et al. (2014) Tumor suppression by miR-26 overrides potential oncogenic activity in intestinal tumorigenesis. Genes Dev 28:2585-90|
|Kelkar, Dhanashree S; Provost, Elayne; Chaerkady, Raghothama et al. (2014) Annotation of the zebrafish genome through an integrated transcriptomic and proteomic analysis. Mol Cell Proteomics 13:3184-98|
|Smith, Cory; Gore, Athurva; Yan, Wei et al. (2014) Whole-genome sequencing analysis reveals high specificity of CRISPR/Cas9 and TALEN-based genome editing in human iPSCs. Cell Stem Cell 15:12-3|
|Sharma, Neeraj; Sosnay, Patrick R; Ramalho, Anabela S et al. (2014) Experimental assessment of splicing variants using expression minigenes and comparison with in silico predictions. Hum Mutat 35:1249-59|
|Hubbi, Maimon E; Gilkes, Daniele M; Hu, Hongxia et al. (2014) Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1? to promote cell-cycle progression. Proc Natl Acad Sci U S A 111:E3325-34|
|Debeljak, Marija; Freed, Donald N; Welch, Jane A et al. (2014) Haplotype counting by next-generation sequencing for ultrasensitive human DNA detection. J Mol Diagn 16:495-503|
|Xiang, Lisha; Gilkes, Daniele M; Chaturvedi, Pallavi et al. (2014) Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer. J Mol Med (Berl) 92:151-64|
|Fu, Yi-Ping; Kohaar, Indu; Moore, Lee E et al. (2014) The 19q12 bladder cancer GWAS signal: association with cyclin E function and aggressive disease. Cancer Res 74:5808-18|
Showing the most recent 10 out of 47 publications