The mission of the UCLA-Caltech MSTP is to promote the education of outstanding physician-scientists. To fulfill this mission, our current goals are to 1) recruit exceptionally bright and accomplished students who exhibit an unusual degree of passion for scientific knowledge and a life-long commitment to research and leadership, 2) help guide admitted students toward outstanding training environments that encourage individual thinking and provide students with the tools needed to develop into accomplished physician-scientists, 3) provide a comprehensive support system to meet the trainees'needs and 4) play an increasingly prominent role in guiding the career development of undergraduate students from under-represented ethnic groups and disadvantaged backgrounds. To accomplish these goals as effectively as possible, the UCLA-Caltech MSTP is run by two equal Co-Directors, three Associate Directors, and a strong administrative team, all of whom are deeply committed to the Program. The Program is structured for an average of eight years of study. An integrated, problem-based medical school curriculum is particularly well suited for MSTP students, due to increased time for independent exploration and increased emphasis on research advances that contributed to current knowledge of disease etiology, diagnosis, and treatment. For their Ph.D. research, students choose mentors from a wide array of science and engineering Ph.D. Programs. The MSTP's commitment to excellence was perhaps most apparent when UCLA and Caltech entered into an affiliation agreement fifteen years ago. This affiliation, which provides an opportunity for two students per year to perform their thesis research at Caltech, not only has increased the number of outstanding mentors available to students, but also appears to have increased the Program's visibility and recruitment success. Substantial institutional support from the David Geffen School of Medicine at UCLA and from Caltech has permitted an increase in the size of the MSTP, with 97 students currently enrolled in the program. The MSTP derives great benefit from recent dramatic improvements in physical facilities at both UCLA and Caltech, from the financial health of the universities, and from the recruitment of a large number of outstanding new faculty members to UCLA and Caltech.

Public Health Relevance

The mission of the UCLA-Caltech MSTP is to promote the training of outstanding physician-scientists. The goal is to transform the future of clinical medicine by educating a cadre of doctors who will engage in both clinical care and biomedical research. Such an integration of clinical medicine and scientific research is likely to lead to an improved understanding of human disease and to the discovery of effective new cures for disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
3T32GM008042-32S1
Application #
8851422
Study Section
(TWD)
Program Officer
Preusch, Peter
Project Start
1983-07-01
Project End
2018-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
32
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Thompson, John W; Griffin, Matthew E; Hsieh-Wilson, Linda C (2018) Methods for the Detection, Study, and Dynamic Profiling of O-GlcNAc Glycosylation. Methods Enzymol 598:101-135
Patel, Aanand A; Oztug Durer, Zeynep A; van Loon, Aaron P et al. (2018) Drosophila and human FHOD family formin proteins nucleate actin filaments. J Biol Chem 293:532-540
Li, Binsen; Ge, Peng; Murray, Kevin A et al. (2018) Cryo-EM of full-length ?-synuclein reveals fibril polymorphs with a common structural kernel. Nat Commun 9:3609
Thompson, John W; Sorum, Alexander W; Hsieh-Wilson, Linda C (2018) Deciphering the Functions of O-GlcNAc Glycosylation in the Brain: The Role of Site-Specific Quantitative O-GlcNAcomics. Biochemistry 57:4010-4018
Eroglu, Zeynep; Zaretsky, Jesse M; Hu-Lieskovan, Siwen et al. (2018) High response rate to PD-1 blockade in desmoplastic melanomas. Nature 553:347-350
Kerr, Wesley T; Janio, Emily A; Braesch, Chelsea T et al. (2018) An objective score to identify psychogenic seizures based on age of onset and history. Epilepsy Behav 80:75-83
Rajbhandari, Prashant; Thomas, Brandon J; Feng, An-Chieh et al. (2018) IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure. Cell 172:218-233.e17
Lee, Ernest Y; Wong, Gerard C L; Ferguson, Andrew L (2018) Machine learning-enabled discovery and design of membrane-active peptides. Bioorg Med Chem 26:2708-2718
Bulterys, Philip L; Bulterys, Michelle A; Phommasone, Koukeo et al. (2018) Climatic drivers of melioidosis in Laos and Cambodia: a 16-year case series analysis. Lancet Planet Health 2:e334-e343
Lee, Ernest Y; Lee, Michelle W; Wong, Gerard C L (2018) Modulation of toll-like receptor signaling by antimicrobial peptides. Semin Cell Dev Biol :

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