This application seeks continued support for the Cell and Molecular Biology Training Program (CMBTP) at Case Western Reserve University. The central goal of this program is to train highly motivated students to become outstanding independent investigators capable of applying diverse approaches to solve important problems in modern biology. This objective is achieved through four primary mechanisms: original research beginning with a series of laboratory rotations during the first year; didactic coursework covering both fundamental and advanced concepts; attendance at weekly seminars and journal clubs including but not limited to those sponsored by the CMBTP; and organizing and participating in the annual CMBTP symposium. The Cell and Molecular Biology Training Program pre-dated and was the driving force behind the development of the interdisciplinary Biomedical Sciences Training Program, a highly effective mechanism for recruiting Ph.D. students and overseeing their first year of graduate study. The CMBTP, which provides support for students who have already selected a mentor, in turn benefits from the integrated approach to research fostered by the BSTP. Together, these programs operate hand in hand to provide a wide range of training opportunities, unencumbered by departmental boundaries. Consistent with its interdisciplinary philosophy, trainers affiliated with the CMBTP hold primary appointments in numerous departments. Training grant policies and key decisions about day-to-day operations including the appointment of trainees and changes in the roster of training faculty are made by a Steering Committee representing the diverse Ph.D. programs encompassed by the CMBTP. Candidates for support on the Cell and Molecular Biology Training Grant undergo a rigorous screening process culminating in an interview with the entire Steering Committee covering both current research and career aspirations. In the course of their training under the auspices of the CMBTP, students develop a broad understanding of and appreciation for research employing diverse organisms and approaches that span traditional disciplinary boundaries. The achievements of past and present trainees indicate that the program provides a solid foundation upon which to build a successful research career.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008056-21
Application #
6622778
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Zatz, Marion M
Project Start
1983-09-22
Project End
2007-06-30
Budget Start
2003-07-01
Budget End
2004-06-30
Support Year
21
Fiscal Year
2003
Total Cost
$352,687
Indirect Cost
Name
Case Western Reserve University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Guenther, Ulf-Peter; Weinberg, David E; Zubradt, Meghan M et al. (2018) The helicase Ded1p controls use of near-cognate translation initiation codons in 5' UTRs. Nature 559:130-134
Somoza, Rodrigo A; Correa, Diego; Labat, Ivan et al. (2018) Transcriptome-Wide Analyses of Human Neonatal Articular Cartilage and Human Mesenchymal Stem Cell-Derived Cartilage Provide a New Molecular Target for Evaluating Engineered Cartilage. Tissue Eng Part A 24:335-350
Smolko, Anne E; Shapiro-Kulnane, Laura; Salz, Helen K (2018) The H3K9 methyltransferase SETDB1 maintains female identity in Drosophila germ cells. Nat Commun 9:4155
Forrest, Megan E; Saiakhova, Alina; Beard, Lydia et al. (2018) Colon Cancer-Upregulated Long Non-Coding RNA lincDUSP Regulates Cell Cycle Genes and Potentiates Resistance to Apoptosis. Sci Rep 8:7324
Zhang, Meixiang; Ngo, Justine; Pirozzi, Filomena et al. (2018) Highly efficient methods to obtain homogeneous dorsal neural progenitor cells from human and mouse embryonic stem cells and induced pluripotent stem cells. Stem Cell Res Ther 9:67
Farabaugh, Kenneth T; Majumder, Mithu; Guan, Bo-Jhih et al. (2017) Protein Kinase R Mediates the Inflammatory Response Induced by Hyperosmotic Stress. Mol Cell Biol 37:
Wright, Margaret C; Logan, Gregory J; Bolock, Alexa M et al. (2017) Merkel cells are long-lived cells whose production is stimulated by skin injury. Dev Biol 422:4-13
Bosworth, Colleen M; Grandhi, Sneha; Gould, Meetha P et al. (2017) Detection and quantification of mitochondrial DNA deletions from next-generation sequence data. BMC Bioinformatics 18:407
Niland, Courtney N; Anderson, David R; Jankowsky, Eckhard et al. (2017) The contribution of the C5 protein subunit of Escherichia coli ribonuclease P to specificity for precursor tRNA is modulated by proximal 5' leader sequences. RNA 23:1502-1511
Lucera, Mark B; Fleissner, Zach; Tabler, Caroline O et al. (2017) HIV signaling through CD4 and CCR5 activates Rho family GTPases that are required for optimal infection of primary CD4+ T cells. Retrovirology 14:4

Showing the most recent 10 out of 130 publications