This application seeks continued support for the Cell and Molecular Biology Training Program (CMBTP) at Case Western Reserve University. The central goal of the CMBTP is to train highly motivated graduate students to become outstanding independent investigators capable of applying diverse approaches to solve important problems in modern biology. This objective is achieved through four primary mechanisms: 1) original research beginning with a series of laboratory rotations in the first year;2) rigorous coursework covering fundamental and advanced concepts in lecture/discussion and seminar formats;3) attending and presenting seminars and journal clubs in diverse disciplines;and 4) organizing and participating in the seminar series and symposia sponsored by the CMBTP. The defining element of the CMB research community is its breadth. Members of the training faculty are investigating a diverse array of research problems in biological systems ranging from single molecules to intact organisms. Consistent with its interdisciplinary philosophy, the CMBTP sponsors events that promote interactions and encourage collaboration among students and faculty from numerous programs and departments. This program pre-dated and was the driving force behind the development of the Biomedical Sciences Training Program (BSTP), a highly effective umbrella mechanism for recruiting Ph.D. students to eleven Ph.D. granting units and overseeing their first year of graduate study. The CMBTP dovetails with the BSTP to provide support for students who have already selected a mentor and Ph.D. program (many trainers are affiliated with >1), and benefits from the integrated approach to research fostered by the BSTP. Training grant policies and key decisions including appointment of trainees and training faculty are made by the Director in consultation with a Steering Committee comprised of representatives from each of the contributing programs. Candidates for support are nominated by their mentors and undergo a rigorous screening process culminating in an interview with the entire Steering Committee that covers both current search and long-term career aspirations. In the course of their training, CMBTP students develop an appreciation for approaches that span traditional disciplinary boundaries and are encouraged to interpret their data from multiple perspectives. The achievements of past and present trainees indicate that the program provides a solid foundation upon which to build a successful independent research career. Support is requested for nine predoctoral student positions in alt years, the same number allocated currently. The research pursued by trainees under the auspices of this training program is aimed at enhancing our understanding of basic cellular processes that are perturbed in disease states including cancer, neurological disorders and metabolic defects. Thus, the award will be used to promote improvements in human health.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZGM1-BRT-5 (CG))
Program Officer
Gindhart, Joseph G
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Case Western Reserve University
Schools of Medicine
United States
Zip Code
Knappenberger, Andrew J; Grandhi, Sneha; Sheth, Reena et al. (2017) Phylogenetic sequence analysis and functional studies reveal compensatory amino acid substitutions in loop 2 of human ribonucleotide reductase. J Biol Chem 292:16463-16476
Forrest, Megan E; Khalil, Ahmad M (2017) Review: Regulation of the cancer epigenome by long non-coding RNAs. Cancer Lett 407:106-112
Hannigan, Molly M; Zagore, Leah L; Licatalosi, Donny D (2017) Ptbp2 Controls an Alternative Splicing Network Required for Cell Communication during Spermatogenesis. Cell Rep 19:2598-2612
Athman, Jaffre J; Sande, Obondo J; Groft, Sarah G et al. (2017) Mycobacterium tuberculosis Membrane Vesicles Inhibit T Cell Activation. J Immunol 198:2028-2037
Smith, Jenna E; Baker, Kristian E (2017) Purification of Transcript-Specific mRNP Complexes Formed In Vivo from Saccharomyces cerevisiae. Methods Mol Biol 1648:201-220
Niland, Courtney N; Anderson, David R; Jankowsky, Eckhard et al. (2017) The contribution of the C5 protein subunit of Escherichia coli ribonuclease P to specificity for precursor tRNA is modulated by proximal 5' leader sequences. RNA 23:1502-1511
Bosworth, Colleen M; Grandhi, Sneha; Gould, Meetha P et al. (2017) Detection and quantification of mitochondrial DNA deletions from next-generation sequence data. BMC Bioinformatics 18:407
Merry, Callie R; McMahon, Sarah; Forrest, Megan E et al. (2016) Transcriptome-wide identification of mRNAs and lincRNAs associated with trastuzumab-resistance in HER2-positive breast cancer. Oncotarget 7:53230-53244
Blech-Hermoni, Yotam; Dasgupta, Twishasri; Coram, Ryan J et al. (2016) Identification of Targets of CUG-BP, Elav-Like Family Member 1 (CELF1) Regulation in Embryonic Heart Muscle. PLoS One 11:e0149061
Vijayaraghavan, Jagamya; Kramp, Kristopher; Harris, Michael E et al. (2016) Inhibition of soluble guanylyl cyclase by small molecules targeting the catalytic domain. FEBS Lett 590:3669-3680

Showing the most recent 10 out of 118 publications