This proposal requests continued funding for the Cellular and Molecular Basis of Disease (CMBD) Training Program at Northwestern University. The CMBD program supports comprehensive pre-doctoral graduate training in the life sciences, focusing on the cellular, molecular and biochemical mechanisms used in biological systems and targeted in diseases impacting human health. The CMBD program has provided intradepartmental and interdisciplinary training opportunities for Northwestern life science graduate students for the past 30 years, and has been a centerpiece for cross campus interactions at Northwestern. CMBD trainees are selected primarily from two integrated interdepartmental programs: the Interdepartmental Biological Sciences Graduate Program (IBiS) on the Evanston campus and the Driskill Graduate Training Program in the Life Sciences (DGP) on the Chicago Medical School campus. Students are appointed in the spring quarter of their second year, after they have completed their core coursework and joined their dissertation research laboratories, and they are typically supported for two or three years. As a University-wide training program with 18 trainee positions and a broad spectrum of faculty, CMBD has taken a leadership role in fostering communication and collaboration between researchers on the two campuses, and many collaborative interactions have arisen directly from the monthly student- oriented CMBD Research in Progress meetings. CMBD also facilitates student interactions with scientists at other institutions, both by providing the opportunity for CMBD trainees to present their research at national meetings and conferences, and by bringing outstanding research scientists to Northwestern, through the CMBD seminar and symposia programs. CMBD provides for training of students in the ethical conduct of research, and offers trainees the opportunity to participate in several outstanding career development forums at Northwestern University, most prominently the Bio- Opportunities program. Graduates of the CMBD program have continued as successful and productive scientists at many other institutions and in diverse careers, contributing in important ways to cell and molecular biology research on a national level.

Public Health Relevance

The CMBD training program brings together a community of trainees and mentors whose expertise spans the range from basic to translational research. By fostering communication among these researchers, participants develop a deeper appreciation of how different areas of study relate to one another and how to apply the principles from different disciplines to better integrate biomedical research.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
4T32GM008061-34
Application #
9057048
Study Section
Training and Workforce Development Subcommittee - D (TWD)
Program Officer
Gindhart, Joseph G
Project Start
1983-07-01
Project End
2018-06-30
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
34
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Northwestern University at Chicago
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
160079455
City
Evanston
State
IL
Country
United States
Zip Code
60201
Schmit, Heidi L; Kraft, Lauren M; Lee-Smith, Conor F et al. (2018) The role of mitochondria in anchoring dynein to the cell cortex extends beyond clustering the anchor protein. Cell Cycle 17:1345-1357
DiGiuseppe, Stephen; Rollins, Madeline G; Bartom, Elizabeth T et al. (2018) ZNF598 Plays Distinct Roles in Interferon-Stimulated Gene Expression and Poxvirus Protein Synthesis. Cell Rep 23:1249-1258
Mehta, Kavi; Laimins, Laimonis (2018) Human Papillomaviruses Preferentially Recruit DNA Repair Factors to Viral Genomes for Rapid Repair and Amplification. MBio 9:
Zamanian, Mostafa; Cook, Daniel E; Zdraljevic, Stefan et al. (2018) Discovery of genomic intervals that underlie nematode responses to benzimidazoles. PLoS Negl Trop Dis 12:e0006368
Ritzert, Jeremy T; Lathem, Wyndham W (2018) Depletion of Glucose Activates Catabolite Repression during Pneumonic Plague. J Bacteriol 200:
Dehn, Shirley; Thorp, Edward B (2018) Myeloid receptor CD36 is required for early phagocytosis of myocardial infarcts and induction of Nr4a1-dependent mechanisms of cardiac repair. FASEB J 32:254-264
Hill, Eric M; Petersen, Christian P (2018) Positional information specifies the site of organ regeneration and not tissue maintenance in planarians. Elife 7:
Prasasya, Rexxi D; Mayo, Kelly E (2018) Notch Signaling Regulates Differentiation and Steroidogenesis in Female Mouse Ovarian Granulosa Cells. Endocrinology 159:184-198
Geary, Lauren; LaBonne, Carole (2018) FGF mediated MAPK and PI3K/Akt Signals make distinct contributions to pluripotency and the establishment of Neural Crest. Elife 7:
Meade, Nathan; Furey, Colleen; Li, Hua et al. (2018) Poxviruses Evade Cytosolic Sensing through Disruption of an mTORC1-mTORC2 Regulatory Circuit. Cell 174:1143-1157.e17

Showing the most recent 10 out of 276 publications