This is a competitive renewal application for a long-standing predoctoral training grant in Cellular and Molecular Biology (CMB). The CMB program constitutes the largest biomedical graduate training program at the University of Alabama at Birmingham (UAB) and accounts for approximately 40% of all biomedical trainees joining the institution each year. This program dates back to the early 1970s, at which time a joint cellular and molecular training program was quite visionary. It has been a rigorous and highly successful program enjoying NIH support since 1984 under the current T32. The objective of this predoctoral training program is to recruit a talented and diverse group of undergraduates and prepare them for a successful career in research and teaching with a specific emphasis in cellular and molecular aspects of biomedical science. The participation of over 40 physician scientists as graduate mentors has made this training program exceptionally translational. Since its inception, the CMB program has trained over 700 individuals, 478 over the past 15 years and many have gone on to faculty positions at excellent academic institutions, or research positions in government and industry. Retention throughout graduate training has been exceptional and our placement record shows tremendous success with a large percentage of the trainees obtaining and maintaining employment in the biomedical sciences after their training. This T32 training grant has enhanced the training environment by supporting stipends, tuition, and research allowance for some of the best students recruited by the CMB Program. In addition it has sponsored seminar speakers designated as "CMB distinguished seminar speakers" and visiting lecturers at UAB which have benefited the entire community. Since the last renewal in 2002, the number of faculty preceptors has increased by 30% from 69 to 90 greatly expanding training opportunity for our students. Grant funding has more then doubled and the number of eligible students for training grant support has increased at a similar rate. Currently well over 200 students are competing for only 5 positions. We have made important advances regarding implementation of a problem based curriculum that provides a small group learning experience in which students can pick and choose from up to 8 concurrent course offerings and novel teaching opportunities are offered throughout a student's training.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008111-25
Application #
8302251
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Gindhart, Joseph G
Project Start
1984-09-01
Project End
2013-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
25
Fiscal Year
2012
Total Cost
$191,647
Indirect Cost
$14,858
Name
University of Alabama Birmingham
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Fraser, Kyle B; Moehle, Mark S; Alcalay, Roy N et al. (2016) Urinary LRRK2 phosphorylation predicts parkinsonian phenotypes in G2019S LRRK2 carriers. Neurology 86:994-9
Atwood, Blake L; Woolnough, Jessica L; Lefevre, Gaelle M et al. (2016) Human Argonaute 2 Is Tethered to Ribosomal RNA through MicroRNA Interactions. J Biol Chem 291:17919-28
Pasek, Raymond C; Malarkey, Erik; Berbari, Nicolas F et al. (2016) Coiled-coil domain containing 42 (Ccdc42) is necessary for proper sperm development and male fertility in the mouse. Dev Biol 412:208-18
Fraser, Kyle B; Rawlins, Ashlee B; Clark, Rachel G et al. (2016) Ser(P)-1292 LRRK2 in urinary exosomes is elevated in idiopathic Parkinson's disease. Mov Disord 31:1543-1550
Birket, Susan E; Chu, Kengyeh K; Houser, Grace H et al. (2016) Combination therapy with cystic fibrosis transmembrane conductance regulator modulators augment the airway functional microanatomy. Am J Physiol Lung Cell Mol Physiol 310:L928-39
Wei, Shipeng; Roessler, Bryan C; Icyuz, Mert et al. (2016) Long-range coupling between the extracellular gates and the intracellular ATP binding domains of multidrug resistance protein pumps and cystic fibrosis transmembrane conductance regulator channels. FASEB J 30:1247-62
Rana, Samir; Nam, Hyungwoo; Glover, Matthew E et al. (2016) Protective effects of chronic mild stress during adolescence in the low-novelty responder rat. Stress 19:133-8
Brady, Lillian J; Bartley, Aundrea F; Li, Qin et al. (2016) Transcriptional dysregulation causes altered modulation of inhibition by haloperidol. Neuropharmacology 111:304-313
Glover, Matthew E; Clinton, Sarah M (2016) Of rodents and humans: A comparative review of the neurobehavioral effects of early life SSRI exposure in preclinical and clinical research. Int J Dev Neurosci 51:50-72
McCoy, C R; Golf, S R; Melendez-Ferro, M et al. (2016) Altered metabolic activity in the developing brain of rats predisposed to high versus low depression-like behavior. Neuroscience 324:469-84

Showing the most recent 10 out of 88 publications