The University of Virginia consistently ranks as one of the top public universities in the nation. One of its strengths is biomedical research where it has focused on areas of cell and molecular biology. The University has built outstanding biomedical sciences (four of seven biomedical science departments are ranked in the top 10 in the nation) despite its relatively small size. It has done this by focusing on strong graduate training and cooperation among members of different departments in the School of Medicine, the School of Engineering, and the College of Arts and Sciences. For 27 years the interdisciplinary Cell and Molecular Biology Graduate Program (CMB), whose faculty derives from 10 degree-granting departments and programs, has been bringing together the best biomedical graduate students and faculty from around the campus to generate a training forum that complements what can be learned in a laboratory. CMB training emphasizes exposing students to areas and techniques outside of their expertise, by working with faculty and students from other departments and disciplines. Both one on one as well as group interactions are fostered. Students join the program in their second year, are supported by the training grant for two years, and remain associated with the program until they graduate. The training focuses on the second and third years in graduate school when students are learning to apply class knowledge towards independent thinking and practical use of the scientific method. The CMB program seeks to intensify this transformative period by nurturing the students through a series of poster sessions, data clubs, mixers, symposia and social events that expose the students to outstanding multi- disciplinary science. They learn to present their research and take ownership and pride in their own scientific accomplishments. The success of our trainees shows that the CMB program prepares them for outstanding research and/or teaching careers in academia or industry. Central to America's future is the training of the next generation of America's scientists. This is especially true for the biomedical sciences, which will continue to have an increasing role in both improving health as well as acting as an engine of economic growth. We propose to continue a 27 year old training program designed to complement the training of the best graduate students in Cell and Molecular Biology (CMB) at the University of Virginia with a program designed to nurture young scientists through the transformative period when they lean to apply class knowledge towards independent thinking and practical use of the scientific method. This CMB program at Virginia has a long and distinguished history in training outstanding scientists. This program is still very vital and will continue this tradition.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Gindhart, Joseph G
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Virginia
Schools of Medicine
United States
Zip Code
Wamsley, J Jacob; Kumar, Manish; Allison, David F et al. (2015) Activin upregulation by NF-?B is required to maintain mesenchymal features of cancer stem-like cells in non-small cell lung cancer. Cancer Res 75:426-35
Williams, Margot; Yen, Weiwei; Lu, Xiaowei et al. (2014) Distinct apical and basolateral mechanisms drive planar cell polarity-dependent convergent extension of the mouse neural plate. Dev Cell 29:34-46
Sanchez, Jacint G; Okreglicka, Katarzyna; Chandrasekaran, Viswanathan et al. (2014) The tripartite motif coiled-coil is an elongated antiparallel hairpin dimer. Proc Natl Acad Sci U S A 111:2494-9
Hodges, Jennifer L; Vilchez, Samuel Martin; Asmussen, Hannelore et al. (2014) ?-Actinin-2 mediates spine morphology and assembly of the post-synaptic density in hippocampal neurons. PLoS One 9:e101770
Wheeler, Michael A; Heffner, Danielle L; Kim, Suemin et al. (2014) TNF-?/TNFR1 signaling is required for the development and function of primary nociceptors. Neuron 82:587-602
Bloom, George S (2014) Amyloid-? and tau: the trigger and bullet in Alzheimer disease pathogenesis. JAMA Neurol 71:505-8
Bjerke, Maureen A; Dzamba, Bette J; Wang, Chong et al. (2014) FAK is required for tension-dependent organization of collective cell movements in Xenopus mesendoderm. Dev Biol 394:340-56
Matson, Daniel R; Stukenberg, P Todd (2014) CENP-I and Aurora B act as a molecular switch that ties RZZ/Mad1 recruitment to kinetochore attachment status. J Cell Biol 205:541-54
Haggart, Charles R; Ames, Elizabeth G; Lee, Jae K et al. (2014) Effects of stretch and shortening on gene expression in intact myocardium. Physiol Genomics 46:57-65
Nussbaum, Justin M; Seward, Matthew E; Bloom, George S (2013) Alzheimer disease: a tale of two prions. Prion 7:14-9

Showing the most recent 10 out of 60 publications