This application requests funds to continue support of a well integrated basic and clinical sciences predoctoral training program. The training program links 20 programs in 7 graduate schools within the University of Pittsburgh and Carnegie Mellon University. The two universities provide well equipped modern biomedical clinical and basic science research facilities. Alone the University of Pittsburgh ranks 5th in overall NIH research funding, and with the added expertise of CMU, our program is considered one of the top neuroscience, immunology and bioengineering training centers. We offer a pioneering and flexible curriculum that integrates PhD and MD training throughout the course of the program. Our program focuses primarily on research and clinical training;however, students participate actively in professional development workshops and receive extensive mentoring in developing their careers as combined degree graduates. Ethical training in responsible research conduct is an integral part of the curriculum. Of the training faculty within the affiliated progras, 104 are currently directly involved in the program. PhD thesis advisors are approved by our steering committee. Trainees are provided thorough graduate medical and career advising throughout the program. Upon matriculation, each trainee is assigned a Career Advisor who in conjunction with the Program Director and the entire Career Advisory Committee guide the student throughout their training and beyond into post-doctoral fellowship and residency positions. Currently there are 88 students (6 URM, 1 with disability) in the program. Funds are requested to support from 20-28 trainees for a period of five years beginning July 2012. Data are provided to support our belief that we have a proven history of attracting outstanding trainees and placing them in positions for future career development. Trainees are selected from a national pool of well over 350 applicants with superior academic records. The average MCAT (11) and GPA (3.72) for matriculants are quite competitive with current MST Programs. Graduates of this program continue to achieve premier post doctoral and residency positions while our earliest graduates have obtained world class faculty and industrial positions.

Public Health Relevance

This application seeks funding to support the training of future physician scientists through a combined MD and PhD program. Our highly integrated, innovative and expedient training program is designed to provide instruction in the basic and clinical sciences while at the same time focus on Professional Development to foster the success of our trainees.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
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National Institute of General Medical Sciences Initial Review Group (BRT)
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Preusch, Peter C
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University of Pittsburgh
Schools of Medicine
United States
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Kutten, Johannes C; McGovern, David; Hobson, Christopher M et al. (2015) Decellularized tracheal extracellular matrix supports epithelial migration, differentiation, and function. Tissue Eng Part A 21:75-84
Iheagwara, Uzoma K; Beatty, Pamela L; Van, Phu T et al. (2014) Influenza virus infection elicits protective antibodies and T cells specific for host cell antigens also expressed as tumor-associated antigens: a new view of cancer immunosurveillance. Cancer Immunol Res 2:263-73
Sturm, Joshua; Nguyen, Tuan; Kandler, Karl (2014) Development of intrinsic connectivity in the central nucleus of the mouse inferior colliculus. J Neurosci 34:15032-46
Norris, Callie A; He, Mu; Kang, Liang-I et al. (2014) Synthesis of IL-6 by hepatocytes is a normal response to common hepatic stimuli. PLoS One 9:e96053
Wang, Bo; Kagemann, Larry; Schuman, Joel S et al. (2014) Gold nanorods as a contrast agent for Doppler optical coherence tomography. PLoS One 9:e90690
Catanese Jr, Daniel J; Matthews, Kathleen S (2011) Disconnected Interacting Protein 1 binds with high affinity to pre-tRNA and ADAT. Biochem Biophys Res Commun 414:506-11
Patel, Vivek P; Chu, Charleen T (2011) Nuclear transport, oxidative stress, and neurodegeneration. Int J Clin Exp Pathol 4:215-29
Catanese Jr, Daniel J; Matthews, Kathleen S (2010) High affinity, dsRNA binding by disconnected interacting protein 1. Biochem Biophys Res Commun 399:186-91
Romero, Guillermo; Sneddon, W Bruce; Yang, Yanmei et al. (2010) Parathyroid hormone receptor directly interacts with dishevelled to regulate beta-Catenin signaling and osteoclastogenesis. J Biol Chem 285:14756-63
Bondos, Sarah E; Catanese Jr, Daniel J; Tan, Xin-Xing et al. (2004) Hox transcription factor ultrabithorax Ib physically and genetically interacts with disconnected interacting protein 1, a double-stranded RNA-binding protein. J Biol Chem 279:26433-44

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