This application requests funds to continue support of a well integrated basic and clinical sciences predoctoral training program. The training program links 20 programs in 7 graduate schools within the University of Pittsburgh and Carnegie Mellon University. The two universities provide well equipped modern biomedical clinical and basic science research facilities. Alone the University of Pittsburgh ranks 5th in overall NIH research funding, and with the added expertise of CMU, our program is considered one of the top neuroscience, immunology and bioengineering training centers. We offer a pioneering and flexible curriculum that integrates PhD and MD training throughout the course of the program. Our program focuses primarily on research and clinical training;however, students participate actively in professional development workshops and receive extensive mentoring in developing their careers as combined degree graduates. Ethical training in responsible research conduct is an integral part of the curriculum. Of the training faculty within the affiliated progras, 104 are currently directly involved in the program. PhD thesis advisors are approved by our steering committee. Trainees are provided thorough graduate medical and career advising throughout the program. Upon matriculation, each trainee is assigned a Career Advisor who in conjunction with the Program Director and the entire Career Advisory Committee guide the student throughout their training and beyond into post-doctoral fellowship and residency positions. Currently there are 88 students (6 URM, 1 with disability) in the program. Funds are requested to support from 20-28 trainees for a period of five years beginning July 2012. Data are provided to support our belief that we have a proven history of attracting outstanding trainees and placing them in positions for future career development. Trainees are selected from a national pool of well over 350 applicants with superior academic records. The average MCAT (11) and GPA (3.72) for matriculants are quite competitive with current MST Programs. Graduates of this program continue to achieve premier post doctoral and residency positions while our earliest graduates have obtained world class faculty and industrial positions.

Public Health Relevance

This application seeks funding to support the training of future physician scientists through a combined MD and PhD program. Our highly integrated, innovative and expedient training program is designed to provide instruction in the basic and clinical sciences while at the same time focus on Professional Development to foster the success of our trainees.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008208-25
Application #
8500322
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Preusch, Peter C
Project Start
1987-07-01
Project End
2017-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
25
Fiscal Year
2013
Total Cost
$794,473
Indirect Cost
$33,961
Name
University of Pittsburgh
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Rogal, Shari S; Arnold, Robert M; Chapko, Michael et al. (2016) The Patient-Provider Relationship Is Associated with Hepatitis C Treatment Eligibility: A Prospective Mixed-Methods Cohort Study. PLoS One 11:e0148596
Chidi, Alexis P; Rogal, Shari; Bryce, Cindy L et al. (2016) Cost-effectiveness of new antiviral regimens for treatment-naïve U.S. veterans with hepatitis C. Hepatology 63:428-36
Matta, Benjamin M; Reichenbach, Dawn K; Zhang, Xiaoli et al. (2016) Peri-alloHCT IL-33 administration expands recipient T-regulatory cells that protect mice against acute GVHD. Blood 128:427-39
Chidi, Alexis P; Bryce, Cindy L; Myaskovsky, Larissa et al. (2016) Differences in Physician Referral Drive Disparities in Surgical Intervention for Hepatocellular Carcinoma: A Retrospective Cohort Study. Ann Surg 263:362-8
Chidi, Alexis P; Bryce, Cindy L; Donohue, Julie M et al. (2016) Economic and Public Health Impacts of Policies Restricting Access to Hepatitis C Treatment for Medicaid Patients. Value Health 19:326-34
Kumar, Pawan; Monin, Leticia; Castillo, Patricia et al. (2016) Intestinal Interleukin-17 Receptor Signaling Mediates Reciprocal Control of the Gut Microbiota and Autoimmune Inflammation. Immunity 44:659-71
Tohme, Samer; Yazdani, Hamza O; Al-Khafaji, Ahmed B et al. (2016) Neutrophil Extracellular Traps Promote the Development and Progression of Liver Metastases after Surgical Stress. Cancer Res 76:1367-80
Versace, Amelia; Acuff, Heather; Bertocci, Michele A et al. (2015) White matter structure in youth with behavioral and emotional dysregulation disorders: a probabilistic tractographic study. JAMA Psychiatry 72:367-76
Tohme, Samer; Goswami, Julie; Han, Katrina et al. (2015) Minimally Invasive Resection of Colorectal Cancer Liver Metastases Leads to an Earlier Initiation of Chemotherapy Compared to Open Surgery. J Gastrointest Surg 19:2199-206
Zaidi, Ali H; Saldin, Lindsey T; Kelly, Lori A et al. (2015) MicroRNA signature characterizes primary tumors that metastasize in an esophageal adenocarcinoma rat model. PLoS One 10:e0122375

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