This application requests funds to continue support of a well integrated basic and clinical sciences predoctoral training program. The training program links 20 programs in 7 graduate schools within the University of Pittsburgh and Carnegie Mellon University. The two universities provide well equipped modern biomedical clinical and basic science research facilities. Alone the University of Pittsburgh ranks 5th in overall NIH research funding, and with the added expertise of CMU, our program is considered one of the top neuroscience, immunology and bioengineering training centers. We offer a pioneering and flexible curriculum that integrates PhD and MD training throughout the course of the program. Our program focuses primarily on research and clinical training;however, students participate actively in professional development workshops and receive extensive mentoring in developing their careers as combined degree graduates. Ethical training in responsible research conduct is an integral part of the curriculum. Of the training faculty within the affiliated progras, 104 are currently directly involved in the program. PhD thesis advisors are approved by our steering committee. Trainees are provided thorough graduate medical and career advising throughout the program. Upon matriculation, each trainee is assigned a Career Advisor who in conjunction with the Program Director and the entire Career Advisory Committee guide the student throughout their training and beyond into post-doctoral fellowship and residency positions. Currently there are 88 students (6 URM, 1 with disability) in the program. Funds are requested to support from 20-28 trainees for a period of five years beginning July 2012. Data are provided to support our belief that we have a proven history of attracting outstanding trainees and placing them in positions for future career development. Trainees are selected from a national pool of well over 350 applicants with superior academic records. The average MCAT (11) and GPA (3.72) for matriculants are quite competitive with current MST Programs. Graduates of this program continue to achieve premier post doctoral and residency positions while our earliest graduates have obtained world class faculty and industrial positions.

Public Health Relevance

This application seeks funding to support the training of future physician scientists through a combined MD and PhD program. Our highly integrated, innovative and expedient training program is designed to provide instruction in the basic and clinical sciences while at the same time focus on Professional Development to foster the success of our trainees.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Preusch, Peter C
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Pittsburgh
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Collins, Elliot; Park, Joonkoo; Behrmann, Marlene (2017) Numerosity representation is encoded in human subcortex. Proc Natl Acad Sci U S A 114:E2806-E2815
Dienel, Samuel J; Bazmi, Holly H; Lewis, David A (2017) Development of transcripts regulating dendritic spines in layer 3 pyramidal cells of the monkey prefrontal cortex: Implications for the pathogenesis of schizophrenia. Neurobiol Dis 105:132-141
Kelly, Neil J; Radder, Josiah E; Baust, Jeffrey J et al. (2017) Mouse Genome-Wide Association Study of Preclinical Group II Pulmonary Hypertension Identifies Epidermal Growth Factor Receptor. Am J Respir Cell Mol Biol 56:488-496
Radder, Josiah E; Zhang, Yingze; Gregory, Alyssa D et al. (2017) Extreme Trait Whole-Genome Sequencing Identifies PTPRO as a Novel Candidate Gene in Emphysema with Severe Airflow Obstruction. Am J Respir Crit Care Med 196:159-171
Pradhan-Sundd, Tirthadipa; Zhou, Lili; Vats, Ravi et al. (2017) Dual catenin loss in murine liver causes tight junctional deregulation and progressive intrahepatic cholestasis. Hepatology :
Harvey, Lloyd D; Chan, Stephen Y (2017) Emerging Metabolic Therapies in Pulmonary Arterial Hypertension. J Clin Med 6:
Dandachi, Nadine; Kelly, Neil J; Wood, John P et al. (2017) Macrophage Elastase Induces TRAIL-mediated Tumor Cell Death through Its Carboxy-Terminal Domain. Am J Respir Crit Care Med 196:353-363
Kulkarni, Sucheta; Dolezal, James M; Wang, Huabo et al. (2017) Ribosomopathy-like properties of murine and human cancers. PLoS One 12:e0182705
Ghimire, Kedar; Altmann, Helene M; Straub, Adam C et al. (2017) Nitric oxide: what's new to NO? Am J Physiol Cell Physiol 312:C254-C262
Chidi, Alexis P; Bryce, Cindy L; Myaskovsky, Larissa et al. (2016) Differences in Physician Referral Drive Disparities in Surgical Intervention for Hepatocellular Carcinoma: A Retrospective Cohort Study. Ann Surg 263:362-8

Showing the most recent 10 out of 56 publications