This is a renewal application for training grant support for the Predoctoral Genetics Training Program at the University of Pennsylvania. The goal of the program is to provide broad-based training in cell and molecular biology and in-depth training in genetics in order to prepare young scientists for cutting-edge genetics research and careers in academia, private industry or government. The program brings together faculty from 15 different departments at the Schools of Medicine and Arts and Sciences, as well as the Children's Hospital of Pennsylvania. The combination of a research- oriented medical school and a strong university base provides an excellent environment for graduate education. The program obtains substantial financial support from Biomedical Graduate Studies, an institutional organization that coordinates student recruitment and oversight for many graduate groups. The Genetics and Gene Regulation (GGR) Program is part of the Cell and Molecular Biology Graduate Group, a multidisciplinary Graduate Group that administers the broad core curriculum for our predoctoral trainees. Within the CAMB framework, the GGR Program offers advanced coursework and research training in genetics, and program-specific activities such as an annual Genetics Symposium, trainee seminars, journal cubs and social events. These courses and activities are made available to students from multiple graduate groups, expanding the breadth and reach of our training program. After coursework is completed, the student must pass an oral preliminary exam that consists of a defense of a written NRSA-style thesis research proposal. The student then carries out a significant genetics research project under the direction of a laboratory mentor and the advice of a thesis committee, with additional oversight and mentoring from the training program faculty. Students are selected for two years of training grant support after they have completed coursework, selected a thesis lab and passed their Preliminary exam. Thus, we support students who are highly motivated to carry out genetic research. New enhancements initiated within the last four years include the Genetics Symposium, a requirement for coursework in Bioinformatics, increased emphasis on grant writing skills, and use of Individual Development Plans to guide career discussions and planning. We propose to continue this program at its current size of 8 predoctoral trainees per year.
Genetic changes underlie many human health problems, and genetic information is an increasingly common part of medicine, biomedical research and our everyday lives. Now more than ever it is important to train young scientists to be geneticists who can understand the fundamental principles involved, and who know not only how to use sophisticated genetic tools and technologies, but also how to interpret the results.
|Plasschaert, Robert N; Bartolomei, Marisa S (2015) Tissue-specific regulation and function of Grb10 during growth and neuronal commitment. Proc Natl Acad Sci U S A 112:6841-7|
|Hsiung, Chris C-S; Morrissey, Christapher S; Udugama, Maheshi et al. (2015) Genome accessibility is widely preserved and locally modulated during mitosis. Genome Res 25:213-25|
|Thom, Christopher S; Traxler, Elizabeth A; Khandros, Eugene et al. (2014) Trim58 degrades Dynein and regulates terminal erythropoiesis. Dev Cell 30:688-700|
|Campbell, Amy E; Hsiung, Chris C-S; Blobel, Gerd A (2014) Comparative analysis of mitosis-specific antibodies for bulk purification of mitotic populations by fluorescence-activated cell sorting. Biotechniques 56:90-1, 93-4|
|Plasschaert, Robert N; Vigneau, Sebastien; Tempera, Italo et al. (2014) CTCF binding site sequence differences are associated with unique regulatory and functional trends during embryonic stem cell differentiation. Nucleic Acids Res 42:774-89|
|Leichty, Aaron R; Brisson, Dustin (2014) Selective whole genome amplification for resequencing target microbial species from complex natural samples. Genetics 198:473-81|
|Silverman, Ian M; Li, Fan; Alexander, Anissa et al. (2014) RNase-mediated protein footprint sequencing reveals protein-binding sites throughout the human transcriptome. Genome Biol 15:R3|
|Ideraabdullah, Folami Y; Thorvaldsen, Joanne L; Myers, Jennifer A et al. (2014) Tissue-specific insulator function at H19/Igf2 revealed by deletions at the imprinting control region. Hum Mol Genet 23:6246-59|
|Silverman, Ian M; Li, Fan; Gregory, Brian D (2013) Genomic era analyses of RNA secondary structure and RNA-binding proteins reveal their significance to post-transcriptional regulation in plants. Plant Sci 205-206:55-62|
|Parker, Whitney E; Orlova, Ksenia A; Parker, William H et al. (2013) Rapamycin prevents seizures after depletion of STRADA in a rare neurodevelopmental disorder. Sci Transl Med 5:182ra53|
Showing the most recent 10 out of 65 publications