The objectives and rationale of the Molecular Biophysics (MB) Training Grant are to prepare highly qualified students, with outstanding quantitative and computational skills, to become a creative workforce to lead the basic biomedical research enterprise. The primary focus is on molecular biophysics, spectroscopy and imaging, computational biology and bioinformatics, areas that are major drivers of advances in biological and medical research, and in technology. The program design gives students full access to the diverse research of participating faculty in seven different degree programs (Biochemistry, Biophysics &Computational Biology, Cell &Developmental Biology, Chemistry, Chemical &Biomolecular Engineering, Molecular &Integrative Physiology, and Physics), while providing them with the supportive atmosphere of their own community. Trainees can choose their research advisor from any of the 30 faculty trainers, regardless of department or degree program. Significant features of the training program include hands-on research rotations through at least three faculty labs prior to choosing an advisor, monthly meetings with research presentations, a select curriculum including a course in cell biology specifically designed for students from a physical sciences background and a course on research ethics, and career advising, provided jointly with the Cell &Molecular Biology (CMB) and Chemistry-Biology Interface (CBl) training grants. Ten traineeship stipends are requested, generally to be provided in years 2-3. All trainees will have funds to attend professional meetings, and additional opportunities to assist in recruiting of underrepresented minorities at national student conferences. During their doctoral training (5-6 years on average), most trainees serve on the organizational committee for the Annual MB/CMB Training Grant Symposium. This is entirely run by trainees and is an important organizational experience for the committee members. The Symposium serves the whole campus community of interested students and faculty, providing a professional forum for students to present their research. Trainees also have personal contact with and responsibility for a world-renowned scientist (the keynote speaker) each year.

Public Health Relevance

Quantitative skills in biology have become especially important in the molecular, cell and systems approaches underlying biomedical research. This has created a great opportunity for capturing the imagination and interest of students already well trained in quantitative methods in the physical sciences. The Molecular Biophysics Training Program at Illinois is especially well positioned to serve these students, the future leaders in quantitative biology.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008276-25
Application #
8500323
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Flicker, Paula F
Project Start
1988-09-30
Project End
2014-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
25
Fiscal Year
2013
Total Cost
$338,897
Indirect Cost
$19,103
Name
University of Illinois Urbana-Champaign
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
041544081
City
Champaign
State
IL
Country
United States
Zip Code
61820
Tuttle, Marcus D; Comellas, Gemma; Nieuwkoop, Andrew J et al. (2016) Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein. Nat Struct Mol Biol 23:409-15
Stone, John E; Hallock, Michael J; Phillips, James C et al. (2016) Evaluation of Emerging Energy-Efficient Heterogeneous Computing Platforms for Biomolecular and Cellular Simulation Workloads. IEEE Int Symp Parallel Distrib Process Workshops Phd Forum 2016:89-100
Tuttle, Marcus D; Courtney, Joseph M; Barclay, Alexander M et al. (2016) Preparation of Amyloid Fibrils for Magic-Angle Spinning Solid-State NMR Spectroscopy. Methods Mol Biol 1345:173-83
Desai, Janish; Liu, Yi-Liang; Wei, Hongli et al. (2016) Structure, Function, and Inhibition of Staphylococcus aureus Heptaprenyl Diphosphate Synthase. ChemMedChem 11:1915-23
Mahinthichaichan, Paween; Gennis, Robert B; Tajkhorshid, Emad (2016) All the O2 Consumed by Thermus thermophilus Cytochrome ba3 Is Delivered to the Active Site through a Long, Open Hydrophobic Tunnel with Entrances within the Lipid Bilayer. Biochemistry 55:1265-78
Sun, Chang; Taguchi, Alexander T; Beal, Nathan J et al. (2015) Regulation of the primary quinone binding conformation by the H subunit in reaction centers from Rhodobacter sphaeroides. J Phys Chem Lett 6:4541-6
Taguchi, Alexander T; O'Malley, Patrick J; Wraight, Colin A et al. (2015) Hydrogen bond network around the semiquinone of the secondary quinone acceptor Q(B) in bacterial photosynthetic reaction centers. J Phys Chem B 119:5805-14
Reilly, Daniel T; Kim, Sung Hoon; Katzenellenbogen, John A et al. (2015) Fluorescent Nanoconjugate Derivatives with Enhanced Photostability for Single Molecule Imaging. Anal Chem 87:11048-57
Hwang, Kevin; Wu, Peiwen; Kim, Taejin et al. (2014) Photocaged DNAzymes as a general method for sensing metal ions in living cells. Angew Chem Int Ed Engl 53:13798-802
Taguchi, Alexander T; O'Malley, Patrick J; Wraight, Colin A et al. (2014) Nuclear hyperfine and quadrupole tensor characterization of the nitrogen hydrogen bond donors to the semiquinone of the QB site in bacterial reaction centers: a combined X- and S-band (14,15)N ESEEM and DFT study. J Phys Chem B 118:1501-9

Showing the most recent 10 out of 73 publications