The Houston Area Molecular Biophysics Program (HAMBP) is a Ph.D. research training program in molecular biophysics involving 43 faculty mentors in six educational/research institutions in the Houston- Galveston area: Baylor College of Medicine, Rice University, University of Houston, University of Texas Health Science Center at Houston, University of Texas M.D. Anderson Cancer Center, and University of Texas Medical Branch at Galveston. Because of the large number of faculty, and the large and diverse applicant pool represented by this group of institutions, we propose to maintain our number of funded trainees at 9. Students pursue a rigorous course of study in the classroom and in the laboratory. Program activities required of all trainees include didactic courses in Molecular Biophysics and responsible conduct of research, a weekly seminar, monthly trainee meetings, an annual research symposium and progress review, and attendance and presentation at two annual research conferences. They receive a strong foundation in the fundamentals-of Molecular Biophysics, with exposure to a broad range of topics, and pursue cutting-edge thesis research in world-class biophysics laboratories. Research areas include x-ray crystallography, macromolecular electron microscopy, fluorescence, magnetic resonance and other types of macromolecular spectroscopy, thermodynamics, kinetics, molecular dynamics, theoretical biophysics, protein folding, nucleic acid structure, molecular recognition, and others. Biological structures studied range in size from peptides and lipid mediators to viruses, transcription complexes, and muscle filaments. Supported trainees have included 5 underrepresented minorities, and have had average GRE scores of 78%tile (Q), 82%tile (A), 74%tile(V), with average undergraduate GPAs of 3.50/4.0. The average time-to-degree of the 29 students supported in the last 10 years who have completed their Ph.D. is 5.27 years. The average number of publications per trainee is 3.8 for graduated trainees, including many high-profile papers and journal covers. Alumni have secured excellent positions upon completion of training, and continue to perform research at a high level. The Program is administered by a Steering Committee of representatives from all partner institutions, which closely monitors the progress of trainees, and make decisions about admission of applicant students and mentors. HAMBP is one of several highly successful cooperative training and research ventures of the partner institutions, which together represent a larger pool of research resources and trainees than any single institution in the U.S.

Public Health Relevance

Training in Molecular Biophysics enables research careers leading to fundamental understanding of human disease and development of innovative approaches to diagnostics, therapeutics, and disease prevention. Biophysics provides tools used by all specialties in biomedical research and in medical practice

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008280-25
Application #
8496794
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Flicker, Paula F
Project Start
1988-09-30
Project End
2014-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
25
Fiscal Year
2013
Total Cost
$248,348
Indirect Cost
$19,103
Name
Baylor College of Medicine
Department
Biochemistry
Type
Schools of Medicine
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030
Loehr, James A; Stinnett, Gary R; Hernández-Rivera, Mayra et al. (2016) Eliminating Nox2 reactive oxygen species production protects dystrophic skeletal muscle from pathological calcium influx assessed in vivo by manganese-enhanced magnetic resonance imaging. J Physiol 594:6395-6405
He, Feng; Agosto, Melina A; Anastassov, Ivan A et al. (2016) Phosphatidylinositol-3-phosphate is light-regulated and essential for survival in retinal rods. Sci Rep 6:26978
Tulodziecka, Karolina; Diaz-Rohrer, Barbara B; Farley, Madeline M et al. (2016) Remodeling of the postsynaptic plasma membrane during neural development. Mol Biol Cell 27:3480-3489
Jones, Alicia M; Mehta, Manan M; Thomas, Emily E et al. (2016) The Structure of a Thermophilic Kinase Shapes Fitness upon Random Circular Permutation. ACS Synth Biol 5:415-25
Sun, Zhizeng; Mehta, Shrenik C; Adamski, Carolyn J et al. (2016) Deep Sequencing of Random Mutant Libraries Reveals the Active Site of the Narrow Specificity CphA Metallo-β-Lactamase is Fragile to Mutations. Sci Rep 6:33195
Wensel, Theodore G; Zhang, Zhixian; Anastassov, Ivan A et al. (2016) Structural and molecular bases of rod photoreceptor morphogenesis and disease. Prog Retin Eye Res 55:32-51
Collier, Aaron M; Lyytinen, Outi L; Guo, Yusong R et al. (2016) Initiation of RNA Polymerization and Polymerase Encapsidation by a Small dsRNA Virus. PLoS Pathog 12:e1005523
Pandey, Naresh; Kuypers, Brianna E; Nassif, Barbara et al. (2016) Tolerance of a Knotted Near-Infrared Fluorescent Protein to Random Circular Permutation. Biochemistry 55:3763-73
Zhao, Li; Chen, Yiyun; Bajaj, Amol Onkar et al. (2016) Integrative subcellular proteomic analysis allows accurate prediction of human disease-causing genes. Genome Res 26:660-9
Inoue, Taeko; Griffin, Deric M; Huq, Redwan et al. (2016) Characterization of a novel MR-detectable nanoantioxidant that mitigates the recall immune response. NMR Biomed 29:1436-44

Showing the most recent 10 out of 97 publications