We propose a program for the support of graduate training in the field of Biophysics. The goal of the program is to provide predoctoral students with practical and intellectual training across a diverse range of research topics. These topics cover the activities and interest of a set of faculty linking the Department of Chemistry and the Department of Molecular Biophysics and Biochemistry (MB&B). These 28 trainers are joined by a shared fascination and particular expertise in structural biology, spectroscopy, physical chemistry, computational chemistry, imaging and molecular medicine. Our mission is to impart to our trainees, the intellectual and practical skills needed to engage biophysics at the highest level. In recent years, the importance of biophysics to biomedical research has grown and become increasingly dynamic. It is therefore our goal to develop in our students not only rigor, but also independence and creativity while simultaneously fostering their adventurousness. We aspire and succeed in producing graduates who push at the fronts of Biophysics to become future leaders of the field. The pool of trainees coming to the two departments of this program have backgrounds that span biology, biochemistry, molecular biology, synthetic and physical chemistry, physics and mathematics. They are supported by the training program in their first, second and/or third year of graduate school. Formal course requirements are augmented with qualifying examinations that, in part, compel a student to independently define a research project and defend it orally to a faculty panel. The training program greatly facilitates interactions between the laboratories of the two departments. These are encouraged by first year students taking three rotations in different labs in order to facilitate the selection of a dissertation supervisor. Intensive research on a dissertation topic follows lab selection. This activity is given oversight by regular formal meetings of a committee of three faculty trainers. This trainee's research efforts succeed in producing peer reviewed publications and culminate in a defense of their work. Time to graduation is typically under six years. Formal ethics training and teaching experience are also essential parts of this program. All trainees serve as teaching assistants for one year gaining supervision and guidance from the program faculty. These provisions, combined with the strong intellectual and material resources of the trainers enable the Yale Biophysics Program (YBP) to produce world class graduates.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008283-24
Application #
8103231
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Flicker, Paula F
Project Start
1988-09-30
Project End
2013-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
24
Fiscal Year
2011
Total Cost
$486,068
Indirect Cost
Name
Yale University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Cui, Danica S; Beaumont, Victor; Ginther, Patrick S et al. (2017) Leveraging Reciprocity to Identify and Characterize Unknown Allosteric Sites in Protein Tyrosine Phosphatases. J Mol Biol 429:2360-2372
Cai, Yingying; Liu, Yuting; Culhane, Kelly J et al. (2017) Purification of family B G protein-coupled receptors using nanodiscs: Application to human glucagon-like peptide-1 receptor. PLoS One 12:e0179568
Braun, Anthony R; Lacy, Michael M; Ducas, Vanessa C et al. (2017) ?-Synuclein's Uniquely Long Amphipathic Helix Enhances its Membrane Binding and Remodeling Capacity. J Membr Biol 250:183-193
Hurtley, Anna E; Stone, Elizabeth A; Metrano, Anthony J et al. (2017) Desymmetrization of Diarylmethylamido Bis(phenols) through Peptide-Catalyzed Bromination: Enantiodivergence as a Consequence of a 2 amu Alteration at an Achiral Residue within the Catalyst. J Org Chem 82:11326-11336
Lacy, Michael M; Baddeley, David; Berro, Julien (2017) Single-molecule imaging of the BAR-domain protein Pil1p reveals filament-end dynamics. Mol Biol Cell 28:2251-2259
Huang, Jinqing; Parobek, Alexander; Ganim, Ziad (2016) Octave-spanning mid-infrared pulses by plasma generation in air pumped with an Yb:KGW source. Opt Lett 41:4855-4858
Clarke, Declan; Sethi, Anurag; Li, Shantao et al. (2016) Identifying Allosteric Hotspots with Dynamics: Application to Inter- and Intra-species Conservation. Structure 24:826-837
Lisi, George P; Manley, Gregory A; Hendrickson, Heidi et al. (2016) Dissecting Dynamic Allosteric Pathways Using Chemically Related Small-Molecule Activators. Structure 24:1155-66
Rivalta, Ivan; Lisi, George P; Snoeberger, Ning-Shiuan et al. (2016) Allosteric Communication Disrupted by a Small Molecule Binding to the Imidazole Glycerol Phosphate Synthase Protein-Protein Interface. Biochemistry 55:6484-6494
Shamseldin, Hanan E; Smith, Laura L; Kentab, Amal et al. (2016) Mutation of the mitochondrial carrier SLC25A42 causes a novel form of mitochondrial myopathy in humans. Hum Genet 135:21-30

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