The Stanford Biophysics Program is an interdisciplinary, interdepartmental predoctoral training program for students with backgrounds and interests in the physical sciences and their application to biology. The Program faculty comes from departments in the Schools of Humanities and Sciences, Medicine, Engineering, and the Stanford Synchrotron Radiation Laboratory. Student training and research centers on the application of physical and chemical principles and methods to solving biological problems, and the development of new methods. The major areas of modern biophysics are represented in the Program, principally the molecular basis of macromolecular function including structural biology, single molecule analysis, and computational biology. The quantitative relationship between molecular properties and higher-level cell and tissue properties, and research in emerging areas of quantitative cell and organ biology, are also well represented. The philosophy of the training program is to develop students with strong quantitative approaches to biological problems, while also developing their perspective in choosing forefront biological problems. There are approximately 30 trainees in the Program, most with undergraduate backgrounds in physical science, biochemistry, or engineering. A balanced academic program tailored to the diverse backgrounds of the students and an acceptable level of performance is insured by first year advising by the Program Director, and annual meetings with the thesis committee. The program requires graduate-level coursework in physical and biological sciences, participation in seminar series, and most importantly the development of a high level of proficiency in independent research. The program trains researchers who apply quantitative methods to understanding the properties of biomolecules, cells, and tissues. This basic research is the cornerstone for developing drugs targeted to specific molecules, understanding the relationships between environmental stimuli and cell and tissue behavior, and developing new methods for detection and treatment of diseases including cancer and neurological pathologies.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Flicker, Paula F
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Stanford University
Schools of Medicine
United States
Zip Code
Zhou, X Edward; He, Yuanzheng; de Waal, Parker W et al. (2017) Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors. Cell 170:457-469.e13
Ursell, Tristan; Lee, Timothy K; Shiomi, Daisuke et al. (2017) Rapid, precise quantification of bacterial cellular dimensions across a genomic-scale knockout library. BMC Biol 15:17
Harrigan, Matthew P; Sultan, Mohammad M; Hernández, Carlos X et al. (2017) MSMBuilder: Statistical Models for Biomolecular Dynamics. Biophys J 112:10-15
Hart, Kevin C; Tan, Jiongyi; Siemers, Kathleen A et al. (2017) E-cadherin and LGN align epithelial cell divisions with tissue tension independently of cell shape. Proc Natl Acad Sci U S A 114:E5845-E5853
Ortega, Fabian E; Rengarajan, Michelle; Chavez, Natalie et al. (2017) Adhesion to the host cell surface is sufficient to mediate Listeria monocytogenes entry into epithelial cells. Mol Biol Cell 28:2945-2957
Latorraca, Naomi R; Fastman, Nathan M; Venkatakrishnan, A J et al. (2017) Mechanism of Substrate Translocation in an Alternating Access Transporter. Cell 169:96-107.e12
Shi, Handuo; Colavin, Alexandre; Lee, Timothy K et al. (2017) Strain Library Imaging Protocol for high-throughput, automated single-cell microscopy of large bacterial collections arrayed on multiwell plates. Nat Protoc 12:429-438
Wacker, Daniel; Wang, Sheng; McCorvy, John D et al. (2017) Crystal Structure of an LSD-Bound Human Serotonin Receptor. Cell 168:377-389.e12
Yi, Bitna; Jahangir, Alam; Evans, Andrew K et al. (2017) Discovery of novel brain permeable and G protein-biased beta-1 adrenergic receptor partial agonists for the treatment of neurocognitive disorders. PLoS One 12:e0180319
Owen, Leanna M; Adhikari, Arjun S; Patel, Mohak et al. (2017) A cytoskeletal clutch mediates cellular force transmission in a soft, three-dimensional extracellular matrix. Mol Biol Cell 28:1959-1974

Showing the most recent 10 out of 128 publications