This Molecular Biophysics pre-doctoral training program involves sixteen mentors from four degree-granting departments and a Purdue-wide life sciences interdisciplinary program, who provide research training linked to studies of the structure and function of proteins, nuclei acids and viruses. The program emphasizes training in three major structural subdisciplines, X-ray crystallography, electron microscopy and image analysis and multidimensional NMR spectroscopy, with a newly added emphasis on protein bioinformatics. Since biophysics and structural biology are not traditional undergraduate disciplines, the curriculum includes courses that offer entry points for students from diverse backgrounds with differing knowledge of biology, chemistry, physics and mathematics, as well as advanced courses that add deeper theoretical and practical understanding. The Program also delivers significant extracurricular experiences that insure breadth of knowledge and prepare the trainees for careers as scientists. Among these are an annual student-organized and student-presented Biophysics Symposium and a series of mentor-organized Biophysical Discussions that focus on the scientific and technical context of key seminars. The faculty mentors have a long and successful history in collaborative research and training that enriches the program and benefits the trainees. Superb major research facilities for crystallography, NMR and electron microscopy have been established and maintained as shared facilities available to all trainees. New facilities to house laboratories for trainees and their mentors are now being constructed, with the entire three floors of the new Hockmeyer Hall building dedicated to structural biophysics research.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
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National Institute of General Medical Sciences Initial Review Group (BRT)
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Flicker, Paula F
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Purdue University
Schools of Arts and Sciences
West Lafayette
United States
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Oliver, Justin C; Gudihal, Ravidra; Burgner, John W et al. (2014) Conformational changes involving ammonia tunnel formation and allosteric control in GMP synthetase. Arch Biochem Biophys 545:22-32
Costakes, Gregory T; Sen, Arpita; Aguilar, R Claudio et al. (2013) Crystallographic analysis of the ENTH domain from yeast epsin Ent2 that induces a cell division phenotype. Protein Sci 22:755-61
Dolan, Patrick T; Zhang, Chaoying; Khadka, Sudip et al. (2013) Identification and comparative analysis of hepatitis C virus-host cell protein interactions. Mol Biosyst 9:3199-209
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St John, Sarah E; Jensen, Katherine C; Kang, Soosung et al. (2013) Design, synthesis, biological and structural evaluation of functionalized resveratrol analogues as inhibitors of quinone reductase 2. Bioorg Med Chem 21:6022-37
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Battisti, Anthony J; Chu, Yong-Kyu; Chipman, Paul R et al. (2011) Structural studies of Hantaan virus. J Virol 85:835-41

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