The UT Southwestern Medical Center at Dallas requests continued support of a predoctoral Molecular Biophysics Training Program. This program selects trainees from within the Graduate Program in Molecular Biophysics (GPMB), one of the eight basic science Ph.D. programs at UT Southwestern, and whose students come from a range of backgrounds in the physical and biological sciences. The GPMB is composed of an interdisciplinary and collaborative group of 37 faculty members drawn from six basic science departments, two clinical departments and four research centers. This group assembles a wide range of expertise in experimental and computational research methods, united by a common interest in the physical basis of biological phenomena at the molecular, cellular and network scales. Trainees receive didactic education that combines a first-year integrated core course across biomedical research areas with advanced instruction in the mathematical, theoretical and practical aspects of biophysics. This is complemented by research rotations and group discussions of the scientific literature and practice. Highlights of the ongoing training that students receive include 1) regular opportunities for students to present their research in seminars and an annual GPMB symposium, 2) opportunities to interact with leaders in the biophysical community through our MB Discussion Group series and 3) intensive research training culminating in the defense of a doctoral dissertation. The highly collaborative environment at UT Southwestern ensures that students participate not only in a range of biophysical research areas, but also in the integration of their findings with colleagues in biochemistry, cell biology and other fields. Now in its 20th year, this training program continues to develop by adding new faculty with skills in a diverse range of research approaches, providing an outstanding foundation for its trainees to pursue academic and industrial research careers.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008297-24
Application #
8294618
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Flicker, Paula F
Project Start
1989-07-01
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
24
Fiscal Year
2012
Total Cost
$125,762
Indirect Cost
$8,490
Name
University of Texas Sw Medical Center Dallas
Department
Biochemistry
Type
Schools of Medicine
DUNS #
800771545
City
Dallas
State
TX
Country
United States
Zip Code
75390
Ayaz, Pelin; Munyoki, Sarah; Geyer, Elisabeth A et al. (2014) A tethered delivery mechanism explains the catalytic action of a microtubule polymerase. Elife 3:e03069
Shoji-Kawata, Sanae; Sumpter, Rhea; Leveno, Matthew et al. (2013) Identification of a candidate therapeutic autophagy-inducing peptide. Nature 494:201-6
Seven, Alpay B; Brewer, Kyle D; Shi, Liang et al. (2013) Prevalent mechanism of membrane bridging by synaptotagmin-1. Proc Natl Acad Sci U S A 110:E3243-52
Huerta, Carlos; Grishin, Nick V; Zhang, Hong (2013) The "super mutant" of yeast FMN adenylyltransferase enhances the enzyme turnover rate by attenuating product inhibition. Biochemistry 52:3615-7
Sauer, David B; Zeng, Weizhong; Canty, John et al. (2013) Sodium and potassium competition in potassium-selective and non-selective channels. Nat Commun 4:2721
Song, Sang-Hun; Freddolino, Peter L; Nash, Abigail I et al. (2011) Modulating LOV domain photodynamics with a residue alteration outside the chromophore binding site. Biochemistry 50:2411-23
Sauer, David B; Zeng, Weizhong; Raghunathan, Srinivasan et al. (2011) Protein interactions central to stabilizing the K+ channel selectivity filter in a four-sited configuration for selective K+ permeation. Proc Natl Acad Sci U S A 108:16634-9
Nash, Abigail I; McNulty, Reginald; Shillito, Mary Elizabeth et al. (2011) Structural basis of photosensitivity in a bacterial light-oxygen-voltage/helix-turn-helix (LOV-HTH) DNA-binding protein. Proc Natl Acad Sci U S A 108:9449-54
Derebe, Mehabaw G; Sauer, David B; Zeng, Weizhong et al. (2011) Tuning the ion selectivity of tetrameric cation channels by changing the number of ion binding sites. Proc Natl Acad Sci U S A 108:598-602
Zoltowski, Brian D; Nash, Abigail I; Gardner, Kevin H (2011) Variations in protein-flavin hydrogen bonding in a light, oxygen, voltage domain produce non-Arrhenius kinetics of adduct decay. Biochemistry 50:8771-9

Showing the most recent 10 out of 33 publications