The Molecular Biophysics Training Grant at Harvard supports a predoctoral training program focused at the interface of the physical and biological sciences. The goal of the program is to provide students with strong undergraduate backgrounds in quantitative sciences (especially physics and mathematics) with broad training in the biophysical, chemical and molecular concepts and techniques that are required to address outstanding problems in biology and biomedical sciences. The training program links a highly interactive group of 46 faculty members from five departments in Harvard's Faculty of Arts and Sciences, the School of Engineering and Applied Sciences, five departments at Harvard Medical School, and four affiliated hospitals. The training program offers a flexible curriculum drawn from courses offered at Harvard, Harvard Medical School, and MIT, and offers research opportunities in a variety of disciplines relevant to molecular biophysics with particular strengths in the areas of structural biology, computational biology, neuroscience, and imaging. In addition to coursework and research activities, the training program sponsors seminars and guest lectures;a student run, student research seminar series;a yearly retreat featuring a poster session and student and faculty talks in the fall semester;a poster session featuring research of program students;a mini- symposium featuring talks by program faculty during the Biophysics Program recruiting weekend in the spring semester;and social events for all trainees. Over the past 24 years, this training program has helped foster a number of new initiatives in graduate training, and has been remarkably successful in promoting collaborative research among its faculty and interdisciplinary training for its students. In this competitive renewal we request support for 16 training slots for students who are affiliated with Harvard's Biophysics Program or who are jointly affiliated with the Harvard Biophysics Program and Medical Engineering and Medical Physics (MEMP) Ph.D. program in the joint Harvard/MIT Health Sciences and Technology initiative (HST). Students will be preferentially funded in their first and second year of graduate studies.

Public Health Relevance

This training program offers interdisciplinary training at the interface between biology and physics in approaches to explore the structure, function and interactions key macromolecules of the cell, the control of cellular processes at the molecular and genome-wide levels, the development of approaches to imaging and modeling these processes, and ultimately the use of this information to diagnose, understand, prevent or cure human diseases.

Agency
National Institute of Health (NIH)
Type
Institutional National Research Service Award (T32)
Project #
2T32GM008313-26
Application #
8607736
Study Section
(TWD)
Program Officer
Flicker, Paula F
Project Start
Project End
Budget Start
Budget End
Support Year
26
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Harvard Medical School
Department
Biochemistry
Type
Schools of Medicine
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02115
Slaymaker, Ian M; Gao, Linyi; Zetsche, Bernd et al. (2016) Rationally engineered Cas9 nucleases with improved specificity. Science 351:84-8
Tabebordbar, Mohammadsharif; Zhu, Kexian; Cheng, Jason K W et al. (2016) In vivo gene editing in dystrophic mouse muscle and muscle stem cells. Science 351:407-11
Serebryany, Eugene; Woodard, Jaie C; Adkar, Bharat V et al. (2016) An Internal Disulfide Locks a Misfolded Aggregation-prone Intermediate in Cataract-linked Mutants of Human γD-Crystallin. J Biol Chem 291:19172-83
Baduel, Pierre; Arnold, Brian; Weisman, Cara M et al. (2016) Habitat-Associated Life History and Stress-Tolerance Variation in Arabidopsis arenosa. Plant Physiol 171:437-51
Arnold, Brian J; Lahner, Brett; DaCosta, Jeffrey M et al. (2016) Borrowed alleles and convergence in serpentine adaptation. Proc Natl Acad Sci U S A 113:8320-5
Woodard, Jaie C; Dunatunga, Sachith; Shakhnovich, Eugene I (2016) A Simple Model of Protein Domain Swapping in Crowded Cellular Environments. Biophys J 110:2367-76
Nelson, Christopher E; Hakim, Chady H; Ousterout, David G et al. (2016) In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy. Science 351:403-7
Bowen, Spencer L; Fuin, Niccolò; Levine, Michael A et al. (2016) Transmission imaging for integrated PET-MR systems. Phys Med Biol 61:5547-68
Prentice-Mott, Harrison V; Meroz, Yasmine; Carlson, Andreas et al. (2016) Directional memory arises from long-lived cytoskeletal asymmetries in polarized chemotactic cells. Proc Natl Acad Sci U S A 113:1267-72
Song, Dan; Graham, Thomas G W; Loparo, Joseph J (2016) A general approach to visualize protein binding and DNA conformation without protein labelling. Nat Commun 7:10976

Showing the most recent 10 out of 68 publications