The fundamental objective of our Trauma Research Training Program is to prepare surgical trainees for future basic investigation of the pathogenesis of organ dysfunction following severe injury. A secondary objective is to inspire surgical trainees to pursue an academic career in trauma surgery. The rationale for this Program is the fact that trauma continues to be the leading cause of death in the US between the ages of 1-45 years, and the societal costs attributed to trauma exceed those of cancer and heart disease. The design of the Program is a full-time commitment to basic investigation conducted primarily in two well-established surgery laboratories (The University of Colorado Denver) supplemented with related clinical research in a regional Level 1 Trauma Center (Denver Health and Hospital Authority). Relevant experiments will be performed in additional laboratories that focus on characterizing lipids and proteomics. The principal animal model will consist of hemorrhagic shock and tissue injury, and the basic investigation will include therapeutic modulation of inflammation. The fellow will commence their participation in the Program typically after their third year of surgical training (PGY 3), and will be dedicated exclusively to the Program for two years. We are requesting funding for four positions, sequenced so that there are first year and second year fellows assigned to each of the core laboratories.

Public Health Relevance

Trauma due to mechanical injury consumes more societal resources than cancer and heart disease. The primary objective of our Program is to prepare and inspire surgery trainees to pursue professional careers that encompass basic investigation of the fundamental mechanisms responsible for death and disability following trauma.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008315-23
Application #
8493800
Study Section
Special Emphasis Panel (ZGM1-BRT-5 (PD))
Program Officer
Somers, Scott D
Project Start
1991-07-01
Project End
2016-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
23
Fiscal Year
2013
Total Cost
$240,398
Indirect Cost
$17,698
Name
University of Colorado Denver
Department
Surgery
Type
Schools of Medicine
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
Slaughter, Anne L; D'Alessandro, Angelo; Moore, Ernest E et al. (2016) Glutamine metabolism drives succinate accumulation in plasma and the lung during hemorrhagic shock. J Trauma Acute Care Surg 81:1012-1019
Moore, Hunter B; Moore, Ernest E; Bensard, Denis D (2016) Pediatric emergency department thoracotomy: A 40-year review. J Pediatr Surg 51:315-8
D'Alessandro, Angelo; Moore, Hunter B; Moore, Ernest E et al. (2016) Plasma First Resuscitation Reduces Lactate Acidosis, Enhances Redox Homeostasis, Amino Acid and Purine Catabolism in a Rat Model of Profound Hemorrhagic Shock. Shock 46:173-82
Moore, Hunter B; Moore, Ernest E; Burlew, Clay C et al. (2016) Establishing Benchmarks for Resuscitation of Traumatic Circulatory Arrest: Success-to-Rescue and Survival among 1,708 Patients. J Am Coll Surg 223:42-50
Moore, Hunter B; Moore, Ernest E; Liras, Ioannis N et al. (2016) Acute Fibrinolysis Shutdown after Injury Occurs Frequently and Increases Mortality: A Multicenter Evaluation of 2,540 Severely Injured Patients. J Am Coll Surg 222:347-55
Burlew, Clay Cothren; Moore, Ernest E; Stahel, Philip F et al. (2016) Preperitoneal pelvic packing reduces mortality in patients with life-threatening hemorrhage due to unstable pelvic fractures. J Trauma Acute Care Surg :
Chapman, Michael P; Moore, Ernest E; Moore, Hunter B et al. (2016) Overwhelming tPA release, not PAI-1 degradation, is responsible for hyperfibrinolysis in severely injured trauma patients. J Trauma Acute Care Surg 80:16-23; discussion 23-5
Vogel, Jody A; Newgard, Craig D; Holmes, James F et al. (2016) Validation of the Denver Emergency Department Trauma Organ Failure Score to Predict Post-Injury Multiple Organ Failure. J Am Coll Surg 222:73-82
D'alessandro, Angelo; Nemkov, Travis; Moore, Hunter B et al. (2016) Metabolomics of trauma-associated death: shared and fluid-specific features of human plasma vs lymph. Blood Transfus 14:185-94
D'Alessandro, A; Hansen, K C; Silliman, C C et al. (2015) Metabolomics of AS-5 RBC supernatants following routine storage. Vox Sang 108:131-40

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