The NIGMS/MIT Biotechnology Training Program (BTP) has operated since 1989 to train Ph.D. scientists and engineers at the interface between biology and technology. Initially focused on the production of protein biopharmaceuticals, the BTP's scope has expanded along with the generally accepted meaning of the term Biotechnology. In addition to bioprocess development, Biotechnology now includes discovery activities aimed at understanding disease processes and designing new drugs. BTP training faculty are actively engaged in a broad spectrum of biotechnology research - for example, bioinformatics, tissue engineering, biomolecular design, toxicology, and glycomics. For the purposes of the BTP, Biotechnology can be distinguished from basic life science research both for its applied, goal-oriented flavor, and a quantitative, engineering approach to utilizing and developing new technologies. 19 BTP trainees are currently supported by the BTP, and each serves a 3-year tenure in the program, commencing in the 2nd year of their Ph.D. graduate studies. Trainees are primarily drawn from the graduate programs of the departments of Biological Engineering, Chemistry, and Chemical Engineering. To meet the goals of the BTP, interdisciplinary training is provided in the form of a 2-3 month off-site industrial internship, cross-departmental coursework, a Meet-the-Lab seminar series, an annual BTP retreat, once- per-semester pizza luncheons, and training in the responsible conduct of research. Complete information on the operation and activities of the BTP are made available to all trainees at http://web.mit.edu/bpec/biotech/. BTP alumni have achieved noteworthy successes in the Biotechnology industry as well as in faculty positions. Appointment to the BTP is extremely competitive, with only a 53% success rate for nominations. We are therefore requesting an increase in support to 22 positions, to provide this cross-disciplinary training to a greater number of these deserving candidates.

Public Health Relevance

This Biotechnology Training Program provides a unique and valuable interdisciplinary training experience in Biotechnology for Ph.D. life scientists and engineers, preparing them to contribute to the Biotechnology industry that is the primary engine of innovation in developing new drugs and therapeutic technologies.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008334-24
Application #
8316211
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Gerratana, Barbara
Project Start
1989-09-27
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
24
Fiscal Year
2012
Total Cost
$848,437
Indirect Cost
$40,329
Name
Massachusetts Institute of Technology
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
001425594
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Brockman, Irene M; Prather, Kristala L J (2015) Dynamic knockdown of E. coli central metabolism for redirecting fluxes of primary metabolites. Metab Eng 28:104-13
Lee, Jiseok; Bisso, Paul W; Srinivas, Rathi L et al. (2014) Universal process-inert encoding architecture for polymer microparticles. Nat Mater 13:524-9
Simon, Mark D; Heider, Patrick L; Adamo, Andrea et al. (2014) Rapid flow-based peptide synthesis. Chembiochem 15:713-20
Mong, Surin K; Vinogradov, Alexander A; Simon, Mark D et al. (2014) Rapid total synthesis of DARPin pE59 and barnase. Chembiochem 15:721-33
Wrobel, Alexandra T; Johnstone, Timothy C; Deliz Liang, Alexandria et al. (2014) A fast and selective near-infrared fluorescent sensor for multicolor imaging of biological nitroxyl (HNO). J Am Chem Soc 136:4697-705
Zhao, Boyang; Pritchard, Justin R; Lauffenburger, Douglas A et al. (2014) Addressing genetic tumor heterogeneity through computationally predictive combination therapy. Cancer Discov 4:166-74
Gaharwar, Akhilesh K; Avery, Reginald K; Assmann, Alexander et al. (2014) Shear-thinning nanocomposite hydrogels for the treatment of hemorrhage. ACS Nano 8:9833-42
Liang, Alexandria Deliz; Wrobel, Alexandra T; Lippard, Stephen J (2014) A flexible glutamine regulates the catalytic activity of toluene o-xylene monooxygenase. Biochemistry 53:3585-92
Kavanaugh, Nicole L; Zhang, Angela Q; Nobile, Clarissa J et al. (2014) Mucins suppress virulence traits of Candida albicans. MBio 5:e01911
Tang, Shengchang; Glassman, Matthew J; Li, Shuaili et al. (2014) Oxidatively Responsive Chain Extension to Entangle Engineered Protein Hydrogels. Macromolecules 47:791-799

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