This Biotechnology training program at the University of Minnesota has been in existence for twenty years. This program has brought together gifted trainees and faculty trainers from diverse disciplines that interface with biotechnology, and has created an innovative, interdisciplinary research and educational endeavor. In this renewal application, we propose to continue our success in training future scientific leaders in biotechnology. The emphasis in the next grant period will be on the design and synthesis of biological systems for biotechnological applications. It is an area of critical importance to futur innovations and discoveries in biotechnology, and represents an area that is uniquely suited for the combined expertise of our training faculty. In addition to solid education in their traditional disciplines, trainees take two cross-disciplinary courses that teach quantitative approaches for biological questions: """"""""Mathematical Tools for Biotechnology"""""""" and """"""""Analysis and Synthesis of Biological Systems"""""""" course. We believe that future biotechnological engineers should be familiar with modern molecular biological experimental skills. Conversely, biotechnological scientists should have a sound appreciation of quantitative analysis of biological processes. Engineers and scientists alike must have a systems perspective to tackle biological processes in a post-genomic era. In addition, our trainees participate in a biology summer camp and in cross disciplinary workshops, symposia and retreats. Mechanisms are in place to expose trainees to """"""""real world"""""""" biotechnology perspectives through internships and other industrial interactions. We continue to emphasize cultural and racial diversity in our training program by implementing measures to facilitate inclusion of trainees from underrepresented groups. Mandatory training for responsible research conduct is in place. Furthermore, we will continue provide trainees with a global perspective through our international exchange program. The proposed training program will produce well rounded Ph.D. engineers and scientists to lead our country's biotechnology advances in future generations.

Public Health Relevance

This Biotechnology training program at the University of Minnesota has been in existence for twenty years and has brought together gifted trainees and faculty trainers from diverse disciplines that interface with biotechnology;and has created an innovative, cross-disciplinary research and educational endeavor. The emphasis of the next grant period will be on the design and synthesis of biological systems for biotechnology;which is of critical importance to future innovations and discoveries in biotechnology and represents an area that is uniquely suited for the combined expertise of our training faculty.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
2T32GM008347-21A1
Application #
8266058
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Gerratana, Barbara
Project Start
1990-09-25
Project End
2017-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
21
Fiscal Year
2012
Total Cost
$625,455
Indirect Cost
$33,961
Name
University of Minnesota Twin Cities
Department
Miscellaneous
Type
Schools of Arts and Sciences
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Freedman, Kevin J; Otto, Lauren M; Ivanov, Aleksandar P et al. (2016) Nanopore sensing at ultra-low concentrations using single-molecule dielectrophoretic trapping. Nat Commun 7:10217
Riemenschneider, Sonja B; Mattia, Donald J; Wendel, Jacqueline S et al. (2016) Inosculation and perfusion of pre-vascularized tissue patches containing aligned human microvessels after myocardial infarction. Biomaterials 97:51-61
Hauck, Amy K; Bernlohr, David A (2016) Oxidative stress and lipotoxicity. J Lipid Res 57:1976-1986
Finkenstaedt-Quinn, Solaire A; Gruba, Sarah M; Haynes, Christy L (2016) Variations in Fusion Pore Formation in Cholesterol-Treated Platelets. Biophys J 110:922-9
Palsuledesai, Charuta C; Ochocki, Joshua D; Kuhns, Michelle M et al. (2016) Metabolic Labeling with an Alkyne-modified Isoprenoid Analog Facilitates Imaging and Quantification of the Prenylome in Cells. ACS Chem Biol 11:2820-2828
McClintock, Maria K; Kaznessis, Yiannis N; Hackel, Benjamin J (2016) Enterocin A mutants identified by saturation mutagenesis enhance potency towards vancomycin-resistant Enterococci. Biotechnol Bioeng 113:414-23
Gruba, Sarah M; Koseoglu, Secil; Meyer, Audrey F et al. (2015) Platelet membrane variations and their effects on δ-granule secretion kinetics and aggregation spreading among different species. Biochim Biophys Acta 1848:1609-18
Gunsolus, Ian L; Mousavi, Maral P S; Hussein, Kadir et al. (2015) Effects of Humic and Fulvic Acids on Silver Nanoparticle Stability, Dissolution, and Toxicity. Environ Sci Technol 49:8078-86
Otto, Lauren M; Mohr, Daniel A; Johnson, Timothy W et al. (2015) Polarization interferometry for real-time spectroscopic plasmonic sensing. Nanoscale 7:4226-33
Diaz-Rodriguez, Veronica; Ganusova, Elena; Rappe, Todd M et al. (2015) Synthesis of Peptides Containing C-Terminal Esters Using Trityl Side-Chain Anchoring: Applications to the Synthesis of C-Terminal Ester Analogs of the Saccharomyces cerevisiae Mating Pheromone a-Factor. J Org Chem 80:11266-74

Showing the most recent 10 out of 118 publications