This Biotechnology training program at the University of Minnesota has been in existence for twenty years. This program has brought together gifted trainees and faculty trainers from diverse disciplines that interface with biotechnology, and has created an innovative, interdisciplinary research and educational endeavor. In this renewal application, we propose to continue our success in training future scientific leaders in biotechnology. The emphasis in the next grant period will be on the design and synthesis of biological systems for biotechnological applications. It is an area of critical importance to futur innovations and discoveries in biotechnology, and represents an area that is uniquely suited for the combined expertise of our training faculty. In addition to solid education in their traditional disciplines, trainees take two cross-disciplinary courses that teach quantitative approaches for biological questions: """"""""Mathematical Tools for Biotechnology"""""""" and """"""""Analysis and Synthesis of Biological Systems"""""""" course. We believe that future biotechnological engineers should be familiar with modern molecular biological experimental skills. Conversely, biotechnological scientists should have a sound appreciation of quantitative analysis of biological processes. Engineers and scientists alike must have a systems perspective to tackle biological processes in a post-genomic era. In addition, our trainees participate in a biology summer camp and in cross disciplinary workshops, symposia and retreats. Mechanisms are in place to expose trainees to """"""""real world"""""""" biotechnology perspectives through internships and other industrial interactions. We continue to emphasize cultural and racial diversity in our training program by implementing measures to facilitate inclusion of trainees from underrepresented groups. Mandatory training for responsible research conduct is in place. Furthermore, we will continue provide trainees with a global perspective through our international exchange program. The proposed training program will produce well rounded Ph.D. engineers and scientists to lead our country's biotechnology advances in future generations.

Public Health Relevance

This Biotechnology training program at the University of Minnesota has been in existence for twenty years and has brought together gifted trainees and faculty trainers from diverse disciplines that interface with biotechnology;and has created an innovative, cross-disciplinary research and educational endeavor. The emphasis of the next grant period will be on the design and synthesis of biological systems for biotechnology;which is of critical importance to future innovations and discoveries in biotechnology and represents an area that is uniquely suited for the combined expertise of our training faculty.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008347-22
Application #
8496796
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Gerratana, Barbara
Project Start
1990-09-25
Project End
2017-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
22
Fiscal Year
2013
Total Cost
$625,449
Indirect Cost
$33,961
Name
University of Minnesota Twin Cities
Department
Miscellaneous
Type
Schools of Arts and Sciences
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Satori, Chad P; Ramezani, Marzieh; Koopmeiners, Joseph S et al. (2017) Checkpoints for Preliminary Identification of Small Molecules found Enriched in Autophagosomes and Activated Mast Cell Secretions Analyzed by Comparative UPLC/MSe. Anal Methods 9:46-54
Jones, Bryan J; Lim, Huey Yee; Huang, Jun et al. (2017) Comparison of Five Protein Engineering Strategies for Stabilizing an ?/?-Hydrolase. Biochemistry 56:6521-6532
Christenson, James K; Jensen, Matthew R; Goblirsch, Brandon R et al. (2017) Active Multienzyme Assemblies for Long-Chain Olefinic Hydrocarbon Biosynthesis. J Bacteriol 199:
Christenson, James K; Richman, Jack E; Jensen, Matthew R et al. (2017) ?-Lactone Synthetase Found in the Olefin Biosynthesis Pathway. Biochemistry 56:348-351
Chen, Yuqing; Bandyopadhyay, Arpan; Kozlowicz, Briana K et al. (2017) Mechanisms of peptide sex pheromone regulation of conjugation in Enterococcus faecalis. Microbiologyopen 6:
Morales, Eduardo H; Pinto, Camilo A; Luraschi, Roberto et al. (2017) Accumulation of heme biosynthetic intermediates contributes to the antibacterial action of the metalloid tellurite. Nat Commun 8:15320
Quin, M B; Wallin, K K; Zhang, G et al. (2017) Spatial organization of multi-enzyme biocatalytic cascades. Org Biomol Chem 15:4260-4271
Jensen, Matthew R; Goblirsch, Brandon R; Christenson, James K et al. (2017) OleA Glu117 is key to condensation of two fatty-acyl coenzyme A substrates in long-chain olefin biosynthesis. Biochem J 474:3871-3886
Manning, Benjamin M; Gruba, Sarah M; Meyer, Audrey F et al. (2016) Neuropeptide-Induced Mast Cell Degranulation and Characterization of Signaling Modulation in Response to IgE Conditioning. ACS Chem Biol 11:3077-3083
Muratore, Katherine A; Grundhofer, Heather M; Arriaga, Edgar A (2016) Capillary Electrophoresis with Laser-Induced Fluorescent Detection of Immunolabeled Individual Autophagy Organelles Isolated from Liver Tissue. Anal Chem 88:11691-11698

Showing the most recent 10 out of 132 publications