The focus of the Medical Scientist Training Program (MSTP) at the University of Alabama at Birmingham (UAB) is to train outstanding young people in the intellectual discipline of being a scientific investigator and a thoroughly trained physician. Although the ultimate career pathway for individual trainees may range from the conduct of basic biomedical research to clinical trials of novel therapeutic agents or procedures, the net effect of this cadre of investigators will be to increase the translation of basic biomedical understanding into clinical practice. Our Program aims to (1) offer superb classroom training in both basic science education and the fundamentals of clinical education;(2) train students in the tools necessary to become successful biomedical scientists, including grant and manuscript writing and time and laboratory management;and (3) graduate physician-scientists who go on to become leaders in academic medical centers throughout the country. The basic structure of the MSTP curriculum at UAB is similar to most programs with three distinct phases - two years of basic science course work and laboratory rotations in the summers (Pre-clinical Phase), an extended period of laboratory research leading to the PhD (Research Phase), followed by a clinical training leading to the MD degree (Clinical Phase). One key difference in our program is that students take both graduate school coursework and medical school coursework during their first two years and integrate an ambulatory clinic clerkship into their graduate years. Our MSTP students can choose to do their PhD in multiple degree-granting programs on campus and will get their graduate coursework in our new theme based programs, which include cancer biology, human pathoblology, immunology, microbiology, neuroscience, genetics, biomedical engineering, and biochemistry. The average time to complete our program is 7.9 years. The program usually accepts 8 students each year and currently has a total student body of 58 active students. In the current year, the UAB MSTP T32 award provided support for 12 slots, although the study section approved 14 slots. In this application, we propose an increase to a total of 20 training slots over a five-year period.

Public Health Relevance

The rapid advances in biomedical sciences of the past 30 years has resulted in a critical need for well trained investigators who also have direct involvement with clinical Medicine to translate the multiple new discoveries in biomedical science into workable clinical applications. Joint training of the most outstanding individuals in both modern medicine and the special intellectual perspective and technical know-how of basic biomedical science is a key component of meeting this need.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Preusch, Peter C
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Alabama Birmingham
Schools of Medicine
United States
Zip Code
Harms, Frederike Leonie; Girisha, Katta M; Hardigan, Andrew A et al. (2017) Mutations in EBF3 Disturb Transcriptional Profiles and Cause Intellectual Disability, Ataxia, and Facial Dysmorphism. Am J Hum Genet 100:117-127
Souder, Jaclyn Paige; Gorelick, Daniel A (2017) Quantification of Estradiol Uptake in Zebrafish Embryos and Larvae. Toxicol Sci 158:465-474
Ramaker, Ryne C; Savic, Daniel; Hardigan, Andrew A et al. (2017) A genome-wide interactome of DNA-associated proteins in the human liver. Genome Res 27:1950-1960
Ramaker, Ryne C; Lasseigne, Brittany N; Hardigan, Andrew A et al. (2017) RNA sequencing-based cell proliferation analysis across 19 cancers identifies a subset of proliferation-informative cancers with a common survival signature. Oncotarget 8:38668-38681
Rogers, Anna Joy; Rogers, Nathaniel G; Kilgore, Meredith L et al. (2017) Economic Evaluations Comparing a Trial of Labor with an Elective Repeat Cesarean Delivery: A Systematic Review. Value Health 20:163-173
Ramaker, Ryne C; Bowling, Kevin M; Lasseigne, Brittany N et al. (2017) Post-mortem molecular profiling of three psychiatric disorders. Genome Med 9:72
Cornelison, Robert; Dobbin, Zachary C; Katre, Ashwini A et al. (2017) Targeting RNA-Polymerase I in Both Chemosensitive and Chemoresistant Populations in Epithelial Ovarian Cancer. Clin Cancer Res 23:6529-6540
Cohen, Joshua L; Ata, Anooshah E; Jackson, Nateka L et al. (2017) Differential stress induced c-Fos expression and identification of region-specific miRNA-mRNA networks in the dorsal raphe and amygdala of high-responder/low-responder rats. Behav Brain Res 319:110-123
Alonso, Arnald; Lasseigne, Brittany N; Williams, Kelly et al. (2017) aRNApipe: a balanced, efficient and distributed pipeline for processing RNA-seq data in high-performance computing environments. Bioinformatics 33:1727-1729
Kirby, Marie K; Ramaker, Ryne C; Roberts, Brian S et al. (2017) Genome-wide DNA methylation measurements in prostate tissues uncovers novel prostate cancer diagnostic biomarkers and transcription factor binding patterns. BMC Cancer 17:273

Showing the most recent 10 out of 80 publications