This application requests continued support for a Predoctoral Training Program in Biotechnology that was first funded in 1990. Twenty nine participating faculty are drawn from six departments and four colleges: Chemistry, (College of Liberal Arts &Sciences);Biochemistry, Microbiology (College of Medicine);Civil &Environmental Engineering, Chemical &Biochemical Engineering (College of Engineering);Medicinal and Natural Products Chemistry (College of Pharmacy). This diverse faculty provides trainees with disciplinary backgrounds that lead to the Ph.D. degree in their respective departments. The following required activities provide the interdisciplinary background appropriate for biotechnology-oriented careers: a) at least one course in each of the three core areas of biotechnology (Biocatalysis, Bioreactors &Bioseparations, Molecular Biology &Genetics);b) participation in the interdisciplinary seminar """"""""Perspectives in Biocatalysis"""""""";c) participation in the Biocatalysis Seminar Program;d) take a course entitled """"""""Principles of Scholarly Integrity"""""""";e) serve an internship in an industrial or government laboratory;f) present research in the annual Biocatalysis and Bioprocessing Conference. Support for 8 predoctoral trainees is requested. Trainees enter the program in their second year of graduate school, and may be renewed for up to two years of support. The Training Program is administered by the Program Director (Daniel M. Quinn) and co-Director (Amnon Kohen), with staff assistance from the Center for Biocatalysis and Bioprocessing (CBB) and the advice of the Coordinating Committee. The Coordinating Committee also serves as the Executive Committee of the CBB, thereby insuring close coordination between the Training Program and the state-funded Center. An emphasis of the Training Program is the recruitment and training of a diverse cohort of trainees. This emphasis not only addresses national needs but also provides a more inclusive educational experience for the trainees.
Participating faculty laboratories provide trainees with a wide range of research opportunities in the biomedical sciences. Among these are investigations of environmentally friendly biocatalytic processes for chemical transformations, development of new antibiotics and Alzheimer's disease agents, biosensor development, synthesis and evaluation of new anticancer drugs, and new approaches to gene delivery. Training Program coursework enhances trainee understanding of biomedical and bioengineering sciences, and provides guidance in the ethical conduct of research.
|Bodle, Christopher R; Mackie, Duncan I; Hayes, Michael P et al. (2017) Natural Products Discovered in a High-Throughput Screen Identified as Inhibitors of RGS17 and as Cytostatic and Cytotoxic Agents for Lung and Prostate Cancer Cell Lines. J Nat Prod 80:1992-2000|
|Kim, Keehyuk; Plapp, Bryce V (2017) Inversion of substrate stereoselectivity of horse liver alcohol dehydrogenase by substitutions of Ser-48 and Phe-93. Chem Biol Interact 276:77-87|
|Wills, Veronica S; Metzger, Joseph I; Allen, Cheryl et al. (2017) Bishomoisoprenoid triazole bisphosphonates as inhibitors of geranylgeranyl diphosphate synthase. Bioorg Med Chem 25:2437-2444|
|Vanle, Brigitte C; Florang, Virginia R; Murry, Daryl J et al. (2017) Inactivation of glyceraldehyde-3-phosphate dehydrogenase by the dopamine metabolite, 3,4-dihydroxyphenylacetaldehyde. Biochem Biophys Res Commun 492:275-281|
|Stockdale, David P; Titunick, Michelle B; Biegler, Jessica M et al. (2017) Selective opioid growth factor receptor antagonists based on a stilbene isostere. Bioorg Med Chem 25:4464-4474|
|Stockdale, David P; Beutler, John A; Wiemer, David F (2017) Synthesis of amide isosteres of schweinfurthin-based stilbenes. Bioorg Med Chem 25:5483-5489|
|Khorsand, Behnoush; Nicholson, Nate; Do, Anh-Vu et al. (2017) Regeneration of bone using nanoplex delivery of FGF-2 and BMP-2 genes in diaphyseal long bone radial defects in a diabetic rabbit model. J Control Release 248:53-59|
|Karunaratne, Kalani; Luedtke, Nicholas; Quinn, Daniel M et al. (2017) Flavin-dependent thymidylate synthase: N5 of flavin as a Methylene carrier. Arch Biochem Biophys 632:11-19|
|Vance, Nicholas R; Gakhar, Lokesh; Spies, M Ashley (2017) Allosteric Tuning of Caspase-7: A Fragment-Based Drug Discovery Approach. Angew Chem Int Ed Engl 56:14443-14447|
|Hovey, Liam; Fowler, C Andrew; Mahling, Ryan et al. (2017) Calcium triggers reversal of calmodulin on nested anti-parallel sites in the IQ motif of the neuronal voltage-dependent sodium channel NaV1.2. Biophys Chem 224:1-19|
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