Improved diagnosis and treatment of human diseases is driven by the acquisition of basic knowledge in foundational life sciences such as biochemistry, cell biology and molecular biology. The next generation of breakthroughs in biological and biomedical sciences will not come from greater specialization, but rather, will originate at the interface of such diverse biological disciplines. This training program in Biochemistry, Cell and Molecular Biology, currently in its 24th year, draws its faculty and students from the interdepartmental graduate program in Biochemistry, Cell and Developmental Biology (BCDB), one of nine graduate training programs in the Graduate Division of Biological and Biomedical Sciences (GDBBS) at Emory. The BCDB program is highly interdisciplinary with its 48 faculty coming from 13 basic science and clinical departments. There are four overarching themes for faculty research: biochemistry/structural biology, cancer biology, cell biology and developmental biology which facilitate opportunities for multidisciplinary research by trainees. Concomitant with this range of biological problems, the trainee is able to take advantage of diverse model systems and state- of- the-art technical resources. This Program currently supports 7 students each year, who are selected from a pool of approximately 20-25 eligible students in the first three years of the BCDB Program. Seven slots are requested in this renewal. All trainees take a core curriculum that emphasizes the foundations of biochemistry, molecular biology, cell biology, genetics, developmental biology and statistics. Additional courses in scientific writing, seminar presentation, teaching and ethics are also required. Advanced electives are available in the full range of biomedical disciplines to give the student in-depth and individualized preparation for their future careers. The training environment is significantly enhanced by three yearly symposia with national leaders in science, graduate education, and mentorship organized by T32-supported students in addition to monthly journal clubs. Networking of T32 students with these national leaders is designed into each visit and has proven to be catalytic in student development. Furthermore, career development workshops, individual development plans, seminars, and annual scientific retreats provide opportunities for the students to gain experience as scientists, interact, and to develop to their maximum potential. Graduates of this training program acquire multidisciplinary training in the broad areas of cell structure and function, in depth knowledge in the area of dissertation research, and the technical, communicative and analytical skills necessary to pursue an independent research career.

Public Health Relevance

This application requests funds to support the training of 7 graduate students per year in a long-standing interdisciplinary graduate program in Biochemistry, Cell and Molecular Biology. Forty-eight training faculty from 13 departments provide a wealth of diverse research, educational, ethical and career development opportunities for students. The goal is to train the next generation of individuals with advanced knowledge and skills necessary to spearhead innovative breakthroughs in biological and biomedical sciences.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
2T32GM008367-26
Application #
8794783
Study Section
Training and Workforce Development Subcommittee - D (TWD)
Program Officer
Gindhart, Joseph G
Project Start
1990-07-01
Project End
2020-06-30
Budget Start
2015-07-01
Budget End
2016-06-30
Support Year
26
Fiscal Year
2015
Total Cost
Indirect Cost
Name
Emory University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Newman, Laura E; Schiavon, Cara R; Turn, Rachel E et al. (2017) The ARL2 GTPase regulates mitochondrial fusion from the intermembrane space. Cell Logist 7:e1340104
Calderon, Brenda M; Conn, Graeme L (2017) Human noncoding RNA 886 (nc886) adopts two structurally distinct conformers that are functionally opposing regulators of PKR. RNA 23:557-566
Christopher, Michael A; Myrick, Dexter A; Barwick, Benjamin G et al. (2017) LSD1 protects against hippocampal and cortical neurodegeneration. Nat Commun 8:805
Bedi, Brahmchetna; Maurice, Nicholas M; Ciavatta, Vincent T et al. (2017) Peroxisome proliferator-activated receptor-? agonists attenuate biofilm formation by Pseudomonas aeruginosa. FASEB J 31:3608-3621
Weikum, Emily R; Okafor, C Denise; D'Agostino, Emma H et al. (2017) Structural Analysis of the Glucocorticoid Receptor Ligand-Binding Domain in Complex with Triamcinolone Acetonide and a Fragment of the Atypical Coregulator, Small Heterodimer Partner. Mol Pharmacol 92:12-21
Bienkowski, Rick S; Banerjee, Ayan; Rounds, J Christopher et al. (2017) The Conserved, Disease-Associated RNA Binding Protein dNab2 Interacts with the Fragile X Protein Ortholog in Drosophila Neurons. Cell Rep 20:1372-1384
Cutler, Alicia A; Dammer, Eric B; Doung, Duc M et al. (2017) Biochemical isolation of myonuclei employed to define changes to the myonuclear proteome that occur with aging. Aging Cell 16:738-749
Nanes, Benjamin A; Grimsley-Myers, Cynthia M; Cadwell, Chantel M et al. (2017) p120-catenin regulates VE-cadherin endocytosis and degradation induced by the Kaposi sarcoma-associated ubiquitin ligase K5. Mol Biol Cell 28:30-40
Barron, Daniel A; Moberg, Kenneth (2016) Inverse regulation of two classic Hippo pathway target genes in Drosophila by the dimerization hub protein Ctp. Sci Rep 6:22726
Schureck, Marc A; Repack, Adrienne; Miles, Stacey J et al. (2016) Mechanism of endonuclease cleavage by the HigB toxin. Nucleic Acids Res 44:7944-53

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