To train the next generation of scientists, the Christopher S. Bond Life Sciences Center at the University of Missouri, in conjunction with the Departments of Biochemistry, Biological Sciences, Molecular Microbiology and Immunology (MMI), the Pathobiology Area Program (PAP) and the MU Informatics Institute (MUII), have developed a collaborative training program in the Molecular Life Sciences. This proposal requests continued support from the National Institute for General Medical Sciences for a training grant on the Molecular Basis of Gene Expression and Signal Processing. This training grant provides funding to support six trainees per year. The 45 participating faculty members in this training program comprise a select group of outstanding scientists selected from the three departments and two interdisciplinary training programs at MU. Students in this program will participate in a training program that has both department-specific and program-wide components. The departmental components include (1) a set of departmental-specific classes that provide a curriculum appropriate for the particular disciplinary interests of each Fellow, (2)a group of outstanding scientists as mentors and role models for both disciplinary and interdisciplinary research and (3) the opportunity for the Fellows to develop their own skills as teachers by serving as Teaching Assistants or as research mentors to undergraduates. The program-wide components include (4) two required core classes, one in molecular biology and one in bioinformatics, that provide a common foundation in molecular and cellular biology, (5) a student-driven seminar program that provides a broad perspective across diverse scientific disciplines, peer-to-peer interactions and an opportunity to improve oral communication skills, (6) instruction in written communication so that our trainees will acquire skills in manuscript writing and grant preparation needed for their subsequent career, and (7) travel funds that enable our young scientists to present their work at national and international meetings. Working together, these departmental-specific and program-wide components provide our graduate students with both a depth of disciplinary expertise and a breadth of exposure to other disciplines that will enable our graduates to be the scientific leaders of the future.

Public Health Relevance

Biomedical research has the potential to improve human health and reduce pain and suffering caused by disease. However, the questions that drive biomedical research are no longer bounded by the traditional disciplines in the physical and biological sciences. We propose to train the next generation of biomedical scientists, equipping them with deep expertise in a particular discipline and the ability to communicate and collaborate with other scientists across disciplinary boundaries.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Gindhart, Joseph G
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Missouri-Columbia
Schools of Medicine
United States
Zip Code
Swatek, Kirby N; Wilson, Rashaun S; Ahsan, Nagib et al. (2014) Multisite phosphorylation of 14-3-3 proteins by calcium-dependent protein kinases. Biochem J 459:15-25
Robbins, Kate L; Glascock, Jacqueline J; Osman, Erkan Y et al. (2014) Defining the therapeutic window in a severe animal model of spinal muscular atrophy. Hum Mol Genet 23:4559-68
Liscum, Emmanuel; Askinosie, Scott K; Leuchtman, Daniel L et al. (2014) Phototropism: growing towards an understanding of plant movement. Plant Cell 26:38-55
Smith, John M; Salamango, Daniel J; Leslie, Michelle E et al. (2014) Sensitivity to Flg22 is modulated by ligand-induced degradation and de novo synthesis of the endogenous flagellin-receptor FLAGELLIN-SENSING2. Plant Physiol 164:440-54
Osman, Erkan Y; Miller, Madeline R; Robbins, Kate L et al. (2014) Morpholino antisense oligonucleotides targeting intronic repressor Element1 improve phenotype in SMA mouse models. Hum Mol Genet 23:4832-45
Roberts, Renee N; Schlarman, Maggie S; Kariuki, Michael M et al. (2013) Expression profile of the Plasmodium falciparum intra-erythrocytic stage protein, PF3D7_1363700. Malar J 12:66
Glascock, Jacqueline J; Osman, Erkan Y; Wetz, Mary J et al. (2012) Decreasing disease severity in symptomatic, Smn(-/-);SMN2(+/+), spinal muscular atrophy mice following scAAV9-SMN delivery. Hum Gene Ther 23:330-5
Haymaker, Cara L; Guloglu, F Betul; Cascio, Jason A et al. (2012) Bone marrow-derived IL-13Rýý1-positive thymic progenitors are restricted to the myeloid lineage. J Immunol 188:3208-16
Dale, J M; Villalon, E; Shannon, S G et al. (2012) Expressing hNF-LE397K results in abnormal gaiting in a transgenic model of CMT2E. Genes Brain Behav 11:360-5
Beshore, Erica L; McEwen, Tamara J; Jud, Molly C et al. (2011) C. elegans Dicer interacts with the P-granule component GLH-1 and both regulate germline RNPs. Dev Biol 350:370-81

Showing the most recent 10 out of 57 publications