To train the next generation of scientists, the Christopher S. Bond Life Sciences Center at the University of Missouri, in conjunction with the Departments of Biochemistry and Biological Sciences, the graduate program in Molecular Pathogenesis and Therapeutics and the MU Informatics Institute (MUII), have developed a collaborative training program in the Molecular Life Sciences. This proposal requests continued support from the National Institute for General Medical Sciences for a training grant on the Molecular Basis of Gene Expression and Signal Processing. This training grant provides two years of funding and training activities to support the training of six predoctoral trainees per year, who are typically at or near the beginning of their predoctoral training period. The 49 participating faculty members in this training program comprise a select group of outstanding scientists selected from the two departments and the two interdisciplinary training programs at MU. Students in this program will participate in a training program that has both department-specific and program-wide components. The departmental components include (1) department-specific classes that provide a curriculum appropriate for the particular disciplinary interests of each Fellow, (2) a group of outstanding scientists as mentors and role models for both disciplinary and interdisciplinary research and (3) opportunities for the Fellows to develop their own skills as teachers by serving as Teaching Assistants or as research mentors to undergraduates. The program-wide components include (4) required classes in molecular biology and in bioinformatics that provide a common foundation to our trainees, (5) a student-driven seminar program that provides a broad perspective across diverse scientific disciplines, peer-to-peer interactions and an opportunity to improve oral communication skills, (6) instruction in written communication so that our trainees will acquire skills in manuscript writing and grant preparation needed for their subsequent career, and (7) travel funds that enable our young scientists to present their work at national and international meetings. Working together, these departmental-specific and program-wide components provide our graduate students with both a depth of disciplinary expertise and a breadth of exposure to other disciplines that will enable our graduates to be the scientific leaders of the future.

Public Health Relevance

Biomedical research has the potential to improve human health and reduce pain and suffering caused by disease. However, the questions that drive biomedical research are no longer bounded by the traditional disciplines in the physical and biological sciences. We propose to train the next generation of biomedical scientists, equipping them with deep expertise in a particular discipline and the ability to communicate and collaborate with other scientists across disciplinary boundaries.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
2T32GM008396-26
Application #
9208292
Study Section
Training and Workforce Development Subcommittee - D (TWD)
Program Officer
Salazar, Desiree Lynn
Project Start
1991-07-01
Project End
2022-06-30
Budget Start
2017-07-01
Budget End
2018-06-30
Support Year
26
Fiscal Year
2017
Total Cost
Indirect Cost
Name
University of Missouri-Columbia
Department
Biochemistry
Type
Schools of Medicine
DUNS #
153890272
City
Columbia
State
MO
Country
United States
Zip Code
65211
Barik, Subhasis; Ellis, Jason S; Cascio, Jason A et al. (2017) IL-4/IL-13 Heteroreceptor Influences Th17 Cell Conversion and Sensitivity to Regulatory T Cell Suppression To Restrain Experimental Allergic Encephalomyelitis. J Immunol 199:2236-2248
Ukah, Tobechukwu K; Cattin-Roy, Alexis N; Chen, Weirong et al. (2017) On the Role IL-4/IL-13 Heteroreceptor Plays in Regulation of Type 1 Diabetes. J Immunol 199:894-902
Attai, Hedieh; Rimbey, Jeanette; Smith, George P et al. (2017) Expression of a Peptidoglycan Hydrolase from Lytic Bacteriophages Atu_ph02 and Atu_ph03 Triggers Lysis of Agrobacterium tumefaciens. Appl Environ Microbiol 83:
Barik, Subhasis; Miller, Mindy M; Cattin-Roy, Alexis N et al. (2017) IL-4/IL-13 Signaling Inhibits the Potential of Early Thymic Progenitors To Commit to the T Cell Lineage. J Immunol 199:2767-2776
Muenks, Andrew G; Stiers, Kyle M; Beamer, Lesa J (2017) Sequence-structure relationships, expression profiles, and disease-associated mutations in the paralogs of phosphoglucomutase 1. PLoS One 12:e0183563
Lane, Brian J (2016) A leech model for homeostatic plasticity and motor network recovery after loss of descending inputs. J Neurophysiol 115:1752-4
Prior, Stephen H; Byrne, Todd S; Tokmina-Roszyk, Dorota et al. (2016) Path to Collagenolysis: COLLAGEN V TRIPLE-HELIX MODEL BOUND PRODUCTIVELY AND IN ENCOUNTERS BY MATRIX METALLOPROTEINASE-12. J Biol Chem 291:7888-901
Stiers, Kyle M; Kain, Bailee N; Graham, Abigail C et al. (2016) Induced Structural Disorder as a Molecular Mechanism for Enzyme Dysfunction in Phosphoglucomutase 1 Deficiency. J Mol Biol 428:1493-505
Stiers, Kyle M; Lee, Christopher B; Nix, Jay C et al. (2016) Synchrotron-based macromolecular crystallography module for an undergraduate biochemistry laboratory course. J Appl Crystallogr 49:2235-2243
Northcutt, Adam J; Lett, Kawasi M; Garcia, Virginia B et al. (2016) Deep sequencing of transcriptomes from the nervous systems of two decapod crustaceans to characterize genes important for neural circuit function and modulation. BMC Genomics 17:868

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