This proposal seeks funds to support the training of 10 engineering predoctoral students in the interdisciplinary area of cell and tissue engineering. Cell engineering is the integration of engineering principles and methods with cell and molecular biology approaches to solve basic and applied problems in biology and medicine. Tissue engineering refers to the combination of cells, scaffolds/matrices, and biochemical factors to develop biological substitutes that restore, maintain, or improve tissue function. Over the past fifteen years, the Georgia Institute of Technology has assembled a group of 25 faculty with expertise in cell and tissue engineering. These individuals form the Cell and Tissue Engineering Group and the core faculty for this proposed training program. The Group operates as an integrated unit to provide advanced research training in cell and tissue engineering. An important element of this proposal is the strong partnership with Emory University School of Medicine. Cohesiveness within the core faculty group and for the participating students is provided by the Petit Institute for Bioengineering and Bioscience and the Georgia Tech/Emory Center for the Living Tissues (GTEC), an Engineering Research Center established by the National Science Foundation in 1998. The Cellular and Tissue Engineering Group is based in GTEC, which is an integral part of the Petit Institute, and this provides for the interdisciplinary environment in the training program. In addition to this, the key elements in the training program are formal coursework, laboratory experience, and a doctoral dissertation. The foundation for the research thesis is laid through a series of graduate or advanced undergraduate courses in engineering fundamentals, biological and physical sciences, and applied mathematics. In addition, research meetings and seminars are held frequently to expose students to broader issues in cell and tissue engineering. It is this interdisciplinary learning environment, complemented by strong industrial interactions, which is the key element of this proposal for a continuation of our current training grant.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Hagan, Ann A
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Georgia Institute of Technology
Engineering (All Types)
Schools of Engineering
United States
Zip Code
Ahn, Jungho; Sei, Yoshitaka J; Jeon, Noo Li et al. (2017) Tumor Microenvironment on a Chip: The Progress and Future Perspective. Bioengineering (Basel) 4:
Parks, Akia N; McFaline-Figueroa, Jennifer; Coogan, Anne et al. (2017) Supraspinatus tendon overuse results in degenerative changes to tendon insertion region and adjacent humeral cartilage in a rat model. J Orthop Res 35:1910-1918
Mannino, Robert G; Santiago-Miranda, Adriana N; Pradhan, Pallab et al. (2017) 3D microvascular model recapitulates the diffuse large B-cell lymphoma tumor microenvironment in vitro. Lab Chip 17:407-414
Edwards, Erin Elizabeth; Oh, Jaeho; Anilkumar, Ananyaveena et al. (2017) P-, but not E- or L-, selectin-mediated rolling adhesion persistence in hemodynamic flow diverges between metastatic and leukocytic cells. Oncotarget 8:83585-83601
Mehta, Nalini; Lyon, Johnathan G; Patil, Ketki et al. (2017) Bacterial Carriers for Glioblastoma Therapy. Mol Ther Oncolytics 4:1-17
Klosterhoff, Brett S; Tsang, Melissa; She, Didi et al. (2017) Implantable Sensors for Regenerative Medicine. J Biomech Eng 139:
Silva, Joana M; García, José R; Reis, Rui L et al. (2017) Tuning cell adhesive properties via layer-by-layer assembly of chitosan and alginate. Acta Biomater 51:279-293
Klosterhoff, Brett S; Ghee Ong, Keat; Krishnan, Laxminarayanan et al. (2017) Wireless Implantable Sensor for Noninvasive, Longitudinal Quantification of Axial Strain Across Rodent Long Bone Defects. J Biomech Eng 139:
Okafor, Ikechukwu; Raghav, Vrishank; Condado, Jose F et al. (2017) Aortic Regurgitation Generates a Kinematic Obstruction Which Hinders Left Ventricular Filling. Ann Biomed Eng 45:1305-1314
Krishnan, Laxminarayanan; Priddy, Lauren B; Esancy, Camden et al. (2017) Delivery vehicle effects on bone regeneration and heterotopic ossification induced by high dose BMP-2. Acta Biomater 49:101-112

Showing the most recent 10 out of 127 publications