Our training grant objectives are to ensure that our trainees learn state-of-the-art research techniques, the fundamentals of posing a research question, and the critical thinking involved with analyzing data and reporting their results. A training program must train researchers to formulate and write grants, to design and conduct experiments, to perform appropriate statistical analyses and to understand the regulations that are involved in clinical research. To become versatile biomedical researchers, we will have our trainees that are involved in patient-oriented research acquire an understanding of relevant basic science research principals and the corresponding laboratory skills. Our goal is to optimize the interactions between our talented basic- and physician-scientist faculty with trainees in order to produce high quality translational researchers that are capable of collaborating with both clinical researchers and with basic science researchers. We have organized our faculty into five integrated scientific tracks: Neuroscience, Critical Care, Pain and Addiction, Vascular Biology and Bioengineering, and Genomics and Epidemiology. An appropriate senior researcher leads each of these tracks and each track includes physician-scientists and basic scientists. This structure is proposed to foster productive interactions and develop program project grants amongst the researchers with common interests, while allowing training in the diverse areas important to the practice of anesthesia and perioperative medicine. One of the missions of our program is to provide structured training in clinical research methods that are applicable to the dynamic clinical environment. The ultimate goal is to prepare the trainee to become an independent investigator, who will be well trained in clinical and basic research study design methods, analytical techniques and become productive in an academic research environment, and will use the skills to contribute to discoveries that will improve patien outcomes. The program requires a two-year commitment and is geared towards trainees who will have completed training in clinical anesthesia. However, we will also consider full-time research scientists in either basic or clinical arenas whose work supports the mission of academic anesthesiology. Because we have implemented a new innovative four-year residency program that includes 2 years of protected research time, there will be an increased demand for training slots (2/yr) starting in year 18. Therefore, we request to maintain the current allocation in Years 16 and 17, and then request an additional slot, to a total of four, for years 18, 19 and 20. We anticipate that the 1st year innovative research track residents will join the T32 will be year 18 in their CA4 year.

Public Health Relevance

There is an increased need for physicians and allied scientists to bring basic scientific discoveries to patients, and to prove that these discoveries improve patient outcomes. Testing medications and devices in patients and development of biomarkers requires knowledge in regulatory affairs, clinical trial design, and relevant underlying scientific principles and techniques involved in discovery. This training grant will train physicias and allied scientists so that they can bring more scientific discoveries to patients and carefully document the safety, efficacy, and importance of the discoveries.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008440-17
Application #
8487413
Study Section
Special Emphasis Panel (ZGM1-BRT-5 (PD))
Program Officer
Cole, Alison E
Project Start
1995-07-01
Project End
2017-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
17
Fiscal Year
2013
Total Cost
$190,570
Indirect Cost
$13,876
Name
University of California San Francisco
Department
Anesthesiology
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Catapano, Joshua Stephen; John Hawryluk, Gregory William; Whetstone, William et al. (2016) Higher Mean Arterial Pressure Values Correlate with Neurologic Improvement in Patients with Initially Complete Spinal Cord Injuries. World Neurosurg 96:72-79
Hawryluk, Gregory; Whetstone, William; Saigal, Rajiv et al. (2015) Mean Arterial Blood Pressure Correlates with Neurological Recovery after Human Spinal Cord Injury: Analysis of High Frequency Physiologic Data. J Neurotrauma 32:1958-67
Yang, Shun-Tai; Rodriguez-Hernandez, Ana; Walker, Espen J et al. (2015) Adult mouse venous hypertension model: common carotid artery to external jugular vein anastomosis. J Vis Exp :50472
Galli, Lisa M; Munji, Roeben N; Chapman, Susan C et al. (2014) Frizzled10 mediates WNT1 and WNT3A signaling in the dorsal spinal cord of the developing chick embryo. Dev Dyn 243:833-43
Chen, Wanqiu; Young, William L; Su, Hua (2014) Induction of brain arteriovenous malformation in the adult mouse. Methods Mol Biol 1135:309-16
Chen, Wanqiu; Sun, Zhengda; Han, Zhenying et al. (2014) De novo cerebrovascular malformation in the adult mouse after endothelial Alk1 deletion and angiogenic stimulation. Stroke 45:900-2
Chen, Wanqiu; Choi, Eun-Jung; McDougall, Cameron M et al. (2014) Brain arteriovenous malformation modeling, pathogenesis, and novel therapeutic targets. Transl Stroke Res 5:316-29
Kurien, Philip A; Chong, S Y Christin; Ptacek, Louis J et al. (2013) Sick and tired: how molecular regulators of human sleep schedules and duration impact immune function. Curr Opin Neurobiol 23:873-9
Chen, Wanqiu; Guo, Yi; Walker, Espen J et al. (2013) Reduced mural cell coverage and impaired vessel integrity after angiogenic stimulation in the Alk1-deficient brain. Arterioscler Thromb Vasc Biol 33:305-10
Roux, Jérémie; McNicholas, Carmel M; Carles, Michel et al. (2013) IL-8 inhibits cAMP-stimulated alveolar epithelial fluid transport via a GRK2/PI3K-dependent mechanism. FASEB J 27:1095-106

Showing the most recent 10 out of 32 publications