The MD-PhD Program at Tufts University School of Medicine and the Sackler School of Graduate Biomedical Sciences is designed to train physician-scientists. Our goal is to provide an outstanding cadre of investigators well-versed in both the conduct of basic and translational research and in the practice of medicine. We achieve this goal by providing an integrated approach to training, including a newly revised medical curriculum with the flexibility that dual degree students require. Medical training interfaces with eight basic science PhD programs in Biochemistry, Cellular &Molecular Physiology, Cell, Molecular &Developmental Biology, Genetics, Immunology, Molecular Microbiology, Neuroscience, and Pharmacology &Experimental Therapeutics. We have transformed our program during the past six years. We have enhanced trainee advising, and created a new set of MD-PhD Program courses and workshops that provide strong student support and improved program integration. Our new June matriculation date and the ability for our students to explore research during their pre-clinical years of medical school enhance integration and decrease time to degree. Our new medical curriculum allows students to complete a required clerkship prior to entering graduate school in a manner that does not delay the start of research training. A second required four-week clerkship is completed during graduate training, which allows students to stay firmly connected to clinical medicine and also facilitates flexibility in re-entryto medical training when the PhD is complete. In addition to our Clinical Implications of Basic Research course, an annual retreat and our career-oriented dinner program, we have added a series of skill-building workshops. These include preparation for the transition from graduate school to clinical medical training, mentoring for NIH application, a women physician-scientist group and a workshop focused on choosing research-focused residencies. With a strong institutional commitment to the Program, we have expanded our enrollment through a Second Portal program for trainees already enrolled in medical school and increased the size of the incoming first year class to five trainees each year. Our Program has graduated 68 trainees since its inception and 33 are currently enrolled. Five additional trainees are slated to matriculate this June. We are requesting funding for 12 positions in this application.

Public Health Relevance

Improving the health of the American people relies on translating biomedical research findings into new and better ways to prevent and fight disease. Our program trains MD-PhD students to become the physician-scientists who will be well-prepared to carry out this mission. Through our program, students learn to understand key health issues and gain the knowledge to solve these problems through research, thereby opening the door to a better quality of life for people everywhere.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008448-20
Application #
8689065
Study Section
(TWD)
Program Officer
Preusch, Peter
Project Start
1994-07-01
Project End
2018-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
20
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Tufts University
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02111
Davis, Patrick; Reijmers, Leon G (2018) The dynamic nature of fear engrams in the basolateral amygdala. Brain Res Bull 141:44-49
Lewis, Juliana B; Scangarello, Frank A; Murphy, Joanne M et al. (2018) ADAP is an upstream regulator that precedes SLP-76 at sites of TCR engagement and stabilizes signaling microclusters. J Cell Sci 131:
Hui Mingalone, Carrie K; Liu, Zhiyi; Hollander, Judith M et al. (2018) Bioluminescence and second harmonic generation imaging reveal dynamic changes in the inflammatory and collagen landscape in early osteoarthritis. Lab Invest 98:656-669
von Mässenhausen, Anne; Tonnus, Wulf; Himmerkus, Nina et al. (2018) Phenytoin inhibits necroptosis. Cell Death Dis 9:359
Herwald, Sanna E; Zucchi, Paola C; Tan, Shumin et al. (2017) The two transmembrane regions of Candida albicans Dfi1 contribute to its biogenesis. Biochem Biophys Res Commun 488:153-158
Davis, Patrick; Zaki, Yosif; Maguire, Jamie et al. (2017) Cellular and oscillatory substrates of fear extinction learning. Nat Neurosci 20:1624-1633
Vong, Minh; Ludington, Jacob G; Ward, Honorine D et al. (2017) Complete cryspovirus genome sequences from Cryptosporidium parvum isolate Iowa. Arch Virol 162:2875-2879
Ludington, Jacob G; Ward, Honorine D (2016) The Cryptosporidium parvum C-Type Lectin CpClec Mediates Infection of Intestinal Epithelial Cells via Interactions with Sulfated Proteoglycans. Infect Immun 84:1593-1602
Lee, Vallent; MacKenzie, Georgina; Hooper, Andrew et al. (2016) Reduced tonic inhibition in the dentate gyrus contributes to chronic stress-induced impairments in learning and memory. Hippocampus 26:1276-1290
Tyc, Katarzyna M; Herwald, Sanna E; Hogan, Jennifer A et al. (2016) The game theory of Candida albicans colonization dynamics reveals host status-responsive gene expression. BMC Syst Biol 10:20

Showing the most recent 10 out of 23 publications