This proposal requests renewal funding for the Predoctoral Biotechnology Training Program at Northwestern University. This interdisciplinary and interdepartmental Program offers biotechnology training opportunities for a select group of PhD students from five participating units: the Departments of Biological &Chemical Engineering (ChBE), Biomedical Engineering (BME), Material Sciences &Engineering (MSE), Chemistry (Chem), and the Interdepartmental Biological Sciences (IBiS) graduate program. Research opportunities, chosen from among a selection of laboratories in the life sciences, are complemented by a core interdisciplinary curriculum. Three- to 6-month industrial internships expose trainees to the industrial environment of modern biotechnology. All trainees and many preceptors participate in the IBiS, 2-day, off-campus annual retreat, which allows extensive interactions among students and faculty from many disciplines and increases the cohesiveness of the trainee group. The Biotechnology Research in Progress Meetings occur monthly and is the forum where trainees and faculty present and discuss their research results and interact with other trainees. Trainees organize and host a Biotechnology Seminar Series that bring industrial and academic scientists to campus for discussions with trainees. Students also take advantage of several other life sciences-related seminar programs on campus, notably the annual Kellogg Biotechnology Conference and seminars for the Master's in Biotechnology Program. Instruction in the responsible conduct of research is carried out primarily through the course, "Ethics in Biological Research." Trainees are recruited by the Program and the participating units using brochures, www pages, and conference presentations. Intensive efforts are made to recruit student from underrepresented groups, and have been quite successful with 30% of trainees from the past 4 years from underrepresented groups. Trainees have been selected from Chemistry, BME, ChBE, and IBiS, and we propose to add MSE for the renewal due to their efforts in biotechnology research and strength of the faculty and the graduate student pool. The number of preceptors participating in the Program will increase from 31 to 42. An increase from 6 to 8 funded positions is requested to support this expanded preceptor base and available student pool.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008449-19
Application #
8287110
Study Section
Special Emphasis Panel (ZGM1-BRT-2 (MB))
Program Officer
Gerratana, Barbara
Project Start
1993-09-01
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
19
Fiscal Year
2012
Total Cost
$267,927
Indirect Cost
$12,735
Name
Northwestern University at Chicago
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
160079455
City
Evanston
State
IL
Country
United States
Zip Code
60201
Hlavaty, K A; Gibly, R F; Zhang, X et al. (2014) Enhancing human islet transplantation by localized release of trophic factors from PLG scaffolds. Am J Transplant 14:1523-32
Weiss, M S; Peñalver Bernabé, B; Shin, S et al. (2014) Dynamic transcription factor activity and networks during ErbB2 breast oncogenesis and targeted therapy. Integr Biol (Camb) 6:1170-82
Duncan, Mark T; Shin, Seungjin; Wu, Jia J et al. (2014) Dynamic transcription factor activity profiles reveal key regulatory interactions during megakaryocytic and erythroid differentiation. Biotechnol Bioeng 111:2082-94
Ciaccio, Mark F; Finkle, Justin D; Xue, Albert Y et al. (2014) A systems approach to integrative biology: an overview of statistical methods to elucidate association and architecture. Integr Comp Biol 54:296-306
Daringer, Nichole M; Dudek, Rachel M; Schwarz, Kelly A et al. (2014) Modular extracellular sensor architecture for engineering mammalian cell-based devices. ACS Synth Biol 3:892-902
Bryant, Jane; Hlavaty, Kelan A; Zhang, Xiaomin et al. (2014) Nanoparticle delivery of donor antigens for transplant tolerance in allogeneic islet transplantation. Biomaterials 35:8887-94
Beenken-Rothkopf, Liese N; Karfeld-Sulzer, Lindsay S; Davis, Nicolynn E et al. (2013) The incorporation of extracellular matrix proteins in protein polymer hydrogels to improve encapsulated beta-cell function. Ann Clin Lab Sci 43:111-21
Ojima, Yoshihiro; Duncan, Mark Thompson; Nurhayati, Retno Wahyu et al. (2013) Synergistic effect of hydrogen peroxide on polyploidization during the megakaryocytic differentiation of K562 leukemia cells by PMA. Exp Cell Res 319:2205-15
Konieczna, Iwona M; Panuganti, Swapna; DeLuca, Teresa A et al. (2013) Administration of nicotinamide does not increase platelet levels in mice. Blood Cells Mol Dis 50:171-6
Weiss, Michael S; Bernabe, Beatriz Penalver; Shikanov, Ariella et al. (2012) The impact of adhesion peptides within hydrogels on the phenotype and signaling of normal and cancerous mammary epithelial cells. Biomaterials 33:3548-59

Showing the most recent 10 out of 57 publications