We propose a training program designed to attract and train physicians in a two year fellowship devoted to research on the pathophysiology of the response to injury. The goals of this training program are to nurture talented young individuals in the areas of basic-researchand clinical investigation, to teach them to design and perform successful research projects, and to give them a solid background in the ethics and methods of scientific research. The objective of this fellowship is to increase the focus of research on injury within the University of North Carolina and to train individuals to become independent investigators and academic faculty with an interest in the area of trauma. Trainees will be selected from a broad group of candidates. Special efforts will be made to identify minority applicants who will increase the diversity of our trainees in this and other institutions. The training program is two years of full-time effort working with one or more of a large group of talented faculty mentors. Research projects are concentrated in the areas of organ failure after injury, immunology and host resistance. Weekly seminars with the trainees allow them to present their material to the research community. Additionally, trainees are required to present their research at Surgery Grand Rounds, and submit abstracts to national meetings. Two intensive week-long courses, Responsible Conduct of Research and Methods in Clinical Research, are provided for trainees in the first month of the program. Trainees have the opportunity to attend graduate level courses from the broad range available at the UNC-CH and surrounding area universities to enhance their research experience. The Training Advisory Committee will assist the Program Director in recruitment and selection of trainees, approval of trainee's research and didactic plans, assignment of trainee to appropriate Research Training Faculty, and monitoring of program activities. The Program Evaluation Committee will provide overall evaluation of the training program and provide feedback to the Training Committee. . All of the Research Training Faculty in the program are established investigators with current NIH funding or other extramural funding, and are experienced mentors of physician-scientists. The faculty have diverse interests, allowing multiple candidates to find appropriate mentors within the training program. There is a strong institutional history of multidisciplinary collaboration. A group of Clinician-Scientist mentors will provide guidance to trainees through discussion of the clinical dimensions of the research. There is a growing demand for academic trauma surgeons and burn surgeons to both teach subsequent generations of providers as well as develop innovative patient treatments. This training grant is designed to help meet this demand.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZGM1-BRT-5 (PD))
Program Officer
Somers, Scott D
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of North Carolina Chapel Hill
Schools of Medicine
Chapel Hill
United States
Zip Code
Knowlin, Laquanda T; Stanford, Lindsay B; Cairns, Bruce A et al. (2017) The effect of preexisting respiratory co-morbidities on burn outcomes. Burns 43:366-373
Linz, Brandon M L; Neely, Crystal J; Kartchner, Laurel B et al. (2017) Innate Immune Cell Recovery Is Positively Regulated by NLRP12 during Emergency Hematopoiesis. J Immunol 198:2426-2433
Phillips, Michael R; Moore, Scott M; Shah, Mansi et al. (2017) A method for evaluating the murine pulmonary vasculature using micro-computed tomography. J Surg Res 207:115-122
Mendoza, April E; Wybourn, Christopher A; Charles, Anthony G et al. (2017) Routine computed tomography after recent operative exploration for penetrating trauma: What injuries do we miss? J Trauma Acute Care Surg 83:575-578
Eaton, Jessica; Hanif, Asma Bilal; Mulima, Gift et al. (2017) Outcomes Following Exploratory Burr Holes for Traumatic Brain Injury in a Resource Poor Setting. World Neurosurg 105:257-264
Knowlin, Laquanda; Reid, Trista; Williams, Felicia et al. (2017) Burn mortality in patients with preexisting cardiovascular disease. Burns 43:949-955
Lachiewicz, Anne M; Hauck, Christopher G; Weber, David J et al. (2017) Bacterial Infections After Burn Injuries: Impact of Multidrug Resistance. Clin Infect Dis 65:2130-2136
Eitas, Timothy K; Stepp, Wesley H; Sjeklocha, Lucas et al. (2017) Differential regulation of innate immune cytokine production through pharmacological activation of Nuclear Factor-Erythroid-2-Related Factor 2 (NRF2) in burn patient immune cells and monocytes. PLoS One 12:e0184164
Knowlin, Laquanda; Stanford, Lindsay; Cairns, Bruce et al. (2017) The effect of smoking status on burn inhalation injury mortality. Burns 43:495-501
Knowlin, Laquanda; Stanford, Lindsay; Moore, Danier et al. (2016) The measured effect magnitude of co-morbidities on burn injury mortality. Burns 42:1433-1438

Showing the most recent 10 out of 48 publications