The proposed program will provide support for two years of postgraduate research training in the Health Sciences Division of Columbia University to qualified applicants who have committed to or are enrolled in postgraduate clinical training in anesthesiology. The program will provide for four trainees, two in their fifth and two in their sixth postgraduate year. Research opportunities are offered by twenty-one participating faculty members with proven records of success in the training of postdoctoral fellows, both within the Department of Anesthesiology as well as from seven collaborating departments, four in the basic sciences: Pharmacology, Physiology and Cellular Biophysics, Anatomy and Cell Biology, and the multidisciplinary Center for Neurobiology and Behavior;and three clinical departments: Medicine, Pediatrics, and Psychiatry. Research areas include, but are not limited to, modulation of neurotransmission by excitatory amino acids, acetylcholine receptors and ion channels, including calcium, the biology of inflammation and coagulation, neuronal mechanisms of behavior, cytokine biology, airway smooth muscle signaling, mechanisms of cocaine excitotoxicity, adenosine receptor physiology, and developmental autonomic receptor pharmacology. During the first year, the trainee will familiarize him or herself with the problems being investigated in the laboratory of the chosen participating faculty member, as well as the research techniques being used in that laboratory by participating in ongoing research projects. Toward the end of this period of assimilation it is expected that the trainee, with appropriate guidance, will formulate an independent project to be carried out largely during the second year of training, using procedures and techniques learned during the first year. With the continued support of the Department of Anesthesiology following training, this program will lead to the establishment of independent physician-investigators using modern methods and techniques to help meet the research needs of the specialty of anesthesiology in the twenty first century.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZGM1-BRT-5 (TA))
Program Officer
Cole, Alison E
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Columbia University (N.Y.)
Schools of Medicine
New York
United States
Zip Code
Boland, Mary Regina; Rusanov, Alexander; So, Yat et al. (2014) From expert-derived user needs to user-perceived ease of use and usefulness: a two-phase mixed-methods evaluation framework. J Biomed Inform 52:141-50
Townsend, Elizabeth A; Zhang, Yi; Xu, Carrie et al. (2014) Active components of ginger potentiate *-agonist-induced relaxation of airway smooth muscle by modulating cytoskeletal regulatory proteins. Am J Respir Cell Mol Biol 50:115-24
Hao, Tianyong; Rusanov, Alexander; Boland, Mary Regina et al. (2014) Clustering clinical trials with similar eligibility criteria features. J Biomed Inform 52:112-20
Rusanov, Alexander; Weiskopf, Nicole G; Wang, Shuang et al. (2014) Hidden in plain sight: bias towards sick patients when sampling patients with sufficient electronic health record data for research. BMC Med Inform Decis Mak 14:51
Danielsson, Jennifer; Yim, Peter; Rinderspacher, Alison et al. (2014) Chloride channel blockade relaxes airway smooth muscle and potentiates relaxation by ?-agonists. Am J Physiol Lung Cell Mol Physiol 307:L273-82
Spotnitz, Henry M; Cabreriza, Santos E; Wang, Daniel Y et al. (2013) Primary endpoints of the biventricular pacing after cardiac surgery trial. Ann Thorac Surg 96:808-15
Nguyen, Huy V; Havalad, Vinod; Aponte-Patel, Linda et al. (2013) Temporary biventricular pacing decreases the vasoactive-inotropic score after cardiac surgery: a substudy of a randomized clinical trial. J Thorac Cardiovasc Surg 146:296-301
Mintz, C David; Barrett, Kendall M S; Smith, Sarah C et al. (2013) Anesthetics interfere with axon guidance in developing mouse neocortical neurons in vitro via a ?-aminobutyric acid type A receptor mechanism. Anesthesiology 118:825-33
Townsend, Elizabeth A; Emala Sr, Charles W (2013) Quercetin acutely relaxes airway smooth muscle and potentiates ?-agonist-induced relaxation via dual phosphodiesterase inhibition of PLC? and PDE4. Am J Physiol Lung Cell Mol Physiol 305:L396-403
Gallos, George; Remy, Kenneth E; Danielsson, Jennifer et al. (2013) Functional expression of the TMEM16 family of calcium-activated chloride channels in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 305:L625-34

Showing the most recent 10 out of 20 publications