The objective of the Molecular, Cellular and Structural Biology (MCSB) training program is to provide predoctoral students with the knowledge to become skilled experimentalists, effective communicators, and creative thinkers. The training program offers a multidisciplinary course of study leading to the Ph.D. degree and provides students with the opportunity to select one of two programs: Molecular and Cellular Biology or Biochemistry and Structural Biology. Within the Molecular and Cellular Biology Program students additionally specialize either in Biochemistry and Molecular Biology, or Developmental Biology, or Immunology and Pathology. During the first year students enroll in three out of four core courses, Biochemistry, Molecular Genetics, Cell Biology and Structural Biology. Students also initially receive training to critically evaluate and present original research articles in Journal Club, while in subsequent years they orally present their own research. Students gain valuable insights into teaching by serving as teaching assistants for undergraduate classes in the second semester of the first year and the first semester of the second year. Laboratory training experiences, or rotations, which continue throughout their first academic year help the student to select a mentor for his/her thesis research at the end of the first year. After three semesters the students are required to pass a written qualifying exam followed by the preparation of a proposal on their intended research project and the defense of this proposal before a faculty committee. Following successful defense of the proposal, students advance to candidacy and the faculty thesis committee annually monitors the students'progress until successful completion of the project and defense of a written doctoral thesis. In addition, the students present yearly reports on their research progress in a seminar forum to other graduate students, postdoctoral fellows, and faculty. The MCSB training program crosses departmental and institutional boundaries to offer thesis research training in 72 different mentored laboratories at three institutions: Stony Brook University, Brookhaven National Laboratory, and Cold Spring Harbor Laboratory. There are currently 146 students in the program with approximately 25 admissions per year. The top four students in their second and third years will be selected by the Executive Committee as NIH predoctoral trainees on the basis of their first year performance also taking into account their undergraduate achievements.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Gindhart, Joseph G
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
State University New York Stony Brook
Schools of Medicine
Stony Brook
United States
Zip Code
Puchades, Cristina; Rampello, Anthony J; Shin, Mia et al. (2017) Structure of the mitochondrial inner membrane AAA+ protease YME1 gives insight into substrate processing. Science 358:
Rampello, Anthony J; Glynn, Steven E (2017) Identification of a Degradation Signal Sequence within Substrates of the Mitochondrial i-AAA Protease. J Mol Biol 429:873-885
Goto, Hana; Kimmey, Samuel C; Row, Richard H et al. (2017) FGF and canonical Wnt signaling cooperate to induce paraxial mesoderm from tailbud neuromesodermal progenitors through regulation of a two-step epithelial to mesenchymal transition. Development 144:1412-1424
Tramantano, Michael; Sun, Lu; Au, Christy et al. (2016) Constitutive turnover of histone H2A.Z at yeast promoters requires the preinitiation complex. Elife 5:
Shi, Hui; Rampello, Anthony J; Glynn, Steven E (2016) Engineered AAA+ proteases reveal principles of proteolysis at the mitochondrial inner membrane. Nat Commun 7:13301
Row, Richard H; Tsotras, Steve R; Goto, Hana et al. (2016) The zebrafish tailbud contains two independent populations of midline progenitor cells that maintain long-term germ layer plasticity and differentiate in response to local signaling cues. Development 143:244-54
Ramkumar, Nitya; Harvey, Beth M; Lee, Jeffrey D et al. (2015) Protein O-Glucosyltransferase 1 (POGLUT1) Promotes Mouse Gastrulation through Modification of the Apical Polarity Protein CRUMBS2. PLoS Genet 11:e1005551
Werneburg, Glenn T; Henderson, Nadine S; Portnoy, Erica B et al. (2015) The pilus usher controls protein interactions via domain masking and is functional as an oligomer. Nat Struct Mol Biol 22:540-6
Matarlo, Joe S; Evans, Christopher E; Sharma, Indrajeet et al. (2015) Mechanism of MenE inhibition by acyl-adenylate analogues and discovery of novel antibacterial agents. Biochemistry 54:6514-6524
Penzo, Marianna; Habiel, David M; Ramadass, Mahalakshmi et al. (2014) Cell migration to CXCL12 requires simultaneous IKK? and IKK?-dependent NF-?B signaling. Biochim Biophys Acta 1843:1796-1804

Showing the most recent 10 out of 21 publications