The University of Colorado Health Science Center (UCHSC) MD/PhD Program was established in 1983and obtained NIH/MSTP funding in 1993. This is the 3rd competitive review, with an unchanged slot number (14) for the past 10 years. The goal of this Program is to train outstanding physician-scientists who will become the future leaders in their chosen discipline of study. To accomplish this goal, we select students from a national applicant pool, seeking out those candidates whose record of research, academic, and leadership achievements are exemplary. Our pool size has increased significantly, from 55 in 1997to 154 in 2007. We now matriculate ~8 students annually, with a current total of 52 students (51% female;15% URM). The selected MSTP students enter a newly-revised, flexible, yet highly rigorous training program that inter- digitates graduate and medical courses in the first two years, typically entails 3-4 years of thesis work, and is completed with 15-24 months of clinical work. A Clinical Science course, Seminar Series, and a 6-year Longitudinal Clinical experience have been specifically devloped for MSTPs. The students choose from 16 graduate training programs located at three sites: the new UCHSC Anschutz Medical Campus at Fitzsimons, National Jewish Medical Research Center (NJMRC), and the University of Colorado at Boulder(CU- Boulder). These three training sites have a combined grant income totaling almost $700 million. Biochemistry, Biomedical Engineering, and Molecular, Cellular and Developmental Biology Programs are available at CU-Boulder;whereas Biochemistry &Molecular Genetics, Biolnformatics, BioMolecular Structure, Cancer Biology, Cell and Developmental Biology, Human Genetics, Immunology, Microbiology, Molecular Biology, Neurosciences, Pharmacology, Physiology &Biophysics, and Reproductive Science Programs are available at the UCHSC/NJMRC integrated sites. To enhance the success of our MSTP students, we provide career guidance beyond the PhD thesis years, and we work diligently to place our graduates in the very best residencies and fellowships. Since 1983, 62 graduated with both degrees in 8.1 years, with 33 completing all of their training and 21/33 pursuing research in either academics or industry. Since the last submission, we have moved to the new Anschutz Medical Campus, which provides state-of- the-art education, research and clinical facilities, resulting in increases in faculty and training programs.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008497-20
Application #
8280326
Study Section
Special Emphasis Panel (ZGM1-BRT-5 (TG))
Program Officer
Preusch, Peter C
Project Start
1993-07-01
Project End
2013-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
20
Fiscal Year
2012
Total Cost
$460,892
Indirect Cost
$31,838
Name
University of Colorado Denver
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
Morgan, Michael J; Gamez, Graciela; Menke, Christina et al. (2014) Regulation of autophagy and chloroquine sensitivity by oncogenic RAS in vitro is context-dependent. Autophagy 10:1814-26
Clarke, Penny; Leser, J Smith; Quick, Eamon D et al. (2014) Death receptor-mediated apoptotic signaling is activated in the brain following infection with West Nile virus in the absence of a peripheral immune response. J Virol 88:1080-9
de Jesus, Armando J; Kastelowitz, Noah; Yin, Hang (2013) Changes in lipid density induce membrane curvature. RSC Adv 3:13622-13625
Dionne, Kalen R; Tyler, Kenneth L (2013) Slice culture modeling of central nervous system (CNS) viral infection. Methods Mol Biol 1078:97-117
Davidovich, Chen; Zheng, Leon; Goodrich, Karen J et al. (2013) Promiscuous RNA binding by Polycomb repressive complex 2. Nat Struct Mol Biol 20:1250-7
Joshi, Mohan C; Magnan, David; Montminy, Timothy P et al. (2013) Regulation of sister chromosome cohesion by the replication fork tracking protein SeqA. PLoS Genet 9:e1003673
Dionne, Kalen R; Zhuang, Yonghua; Leser, J Smith et al. (2013) Daxx upregulation within the cytoplasm of reovirus-infected cells is mediated by interferon and contributes to apoptosis. J Virol 87:3447-60
Dionne, Kalen R; Galvin, John M; Schittone, Stephanie A et al. (2011) Type I interferon signaling limits reoviral tropism within the brain and prevents lethal systemic infection. J Neurovirol 17:314-26
Dionne, Kalen R; Leser, J Smith; Lorenzen, Kristi A et al. (2011) A brain slice culture model of viral encephalitis reveals an innate CNS cytokine response profile and the therapeutic potential of caspase inhibition. Exp Neurol 228:222-31
Cosper, Pippa F; Leinwand, Leslie A (2011) Cancer causes cardiac atrophy and autophagy in a sexually dimorphic manner. Cancer Res 71:1710-20

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