The University of Colorado Health Science Center (UCHSC) MD/PhD Program was established in 1983and obtained NIH/MSTP funding in 1993. This is the 3rd competitive review, with an unchanged slot number (14) for the past 10 years. The goal of this Program is to train outstanding physician-scientists who will become the future leaders in their chosen discipline of study. To accomplish this goal, we select students from a national applicant pool, seeking out those candidates whose record of research, academic, and leadership achievements are exemplary. Our pool size has increased significantly, from 55 in 1997to 154 in 2007. We now matriculate ~8 students annually, with a current total of 52 students (51% female;15% URM). The selected MSTP students enter a newly-revised, flexible, yet highly rigorous training program that inter- digitates graduate and medical courses in the first two years, typically entails 3-4 years of thesis work, and is completed with 15-24 months of clinical work. A Clinical Science course, Seminar Series, and a 6-year Longitudinal Clinical experience have been specifically devloped for MSTPs. The students choose from 16 graduate training programs located at three sites: the new UCHSC Anschutz Medical Campus at Fitzsimons, National Jewish Medical Research Center (NJMRC), and the University of Colorado at Boulder(CU- Boulder). These three training sites have a combined grant income totaling almost $700 million. Biochemistry, Biomedical Engineering, and Molecular, Cellular and Developmental Biology Programs are available at CU-Boulder;whereas Biochemistry &Molecular Genetics, Biolnformatics, BioMolecular Structure, Cancer Biology, Cell and Developmental Biology, Human Genetics, Immunology, Microbiology, Molecular Biology, Neurosciences, Pharmacology, Physiology &Biophysics, and Reproductive Science Programs are available at the UCHSC/NJMRC integrated sites. To enhance the success of our MSTP students, we provide career guidance beyond the PhD thesis years, and we work diligently to place our graduates in the very best residencies and fellowships. Since 1983, 62 graduated with both degrees in 8.1 years, with 33 completing all of their training and 21/33 pursuing research in either academics or industry. Since the last submission, we have moved to the new Anschutz Medical Campus, which provides state-of- the-art education, research and clinical facilities, resulting in increases in faculty and training programs.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZGM1-BRT-5 (TG))
Program Officer
Preusch, Peter C
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Colorado Denver
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Garcia, Tamara B; Snedeker, Jonathan C; Baturin, Dmitry et al. (2017) A Small-Molecule Inhibitor of WEE1, AZD1775, Synergizes with Olaparib by Impairing Homologous Recombination and Enhancing DNA Damage and Apoptosis in Acute Leukemia. Mol Cancer Ther 16:2058-2068
Iklé, Jennifer M; Tavares, Andre L P; King, Marisol et al. (2017) Nkx2.5 regulates endothelin converting enzyme-1 during pharyngeal arch patterning. Genesis 55:
Jones, Robert T; Felsenstein, Kenneth M; Theodorescu, Dan (2016) Pharmacogenomics: Biomarker-Directed Therapy for Bladder Cancer. Urol Clin North Am 43:77-86
Laumen, Geneviève; Ferber, Alexander T; Klump, Georg M et al. (2016) The Physiological Basis and Clinical Use of the Binaural Interaction Component of the Auditory Brainstem Response. Ear Hear 37:e276-e290
Cohen, Max L; Kim, Sunhong; Morita, Kiyokazu et al. (2015) The GATA factor elt-1 regulates C. elegans developmental timing by promoting expression of the let-7 family microRNAs. PLoS Genet 11:e1005099
Wolf, Andrew B; Lintz, Mario J; Costabile, Jamie D et al. (2015) An integrative role for the superior colliculus in selecting targets for movements. J Neurophysiol 114:2118-31
Morgan, Michael J; Gamez, Graciela; Menke, Christina et al. (2014) Regulation of autophagy and chloroquine sensitivity by oncogenic RAS in vitro is context-dependent. Autophagy 10:1814-26
Clarke, Penny; Leser, J Smith; Quick, Eamon D et al. (2014) Death receptor-mediated apoptotic signaling is activated in the brain following infection with West Nile virus in the absence of a peripheral immune response. J Virol 88:1080-9
Dionne, Kalen R; Tyler, Kenneth L (2013) Slice culture modeling of central nervous system (CNS) viral infection. Methods Mol Biol 1078:97-117
de Jesus, Armando J; Kastelowitz, Noah; Yin, Hang (2013) Changes in lipid density induce membrane curvature. RSC Adv 3:13622-13625

Showing the most recent 10 out of 29 publications