This application requests continuing support for Predoctoral Training in Systems and Integrative Biology with specific emphasis on Graduate Training in Neuroscience. The training program proposed encompasses Neuroscience from the study of such complex systems as the brain's mechanisms for regulating social interactions to the cellular circuitry that underlie the brain's processing of visual information to the molecular biology of synaptic transmission. Trainees receive intensive research experiences including formal classes and individual mentoring over the full range of contemporary Neuroscience including access to state of the art facilities for interactive human functional brain imaging, high resolution optical imaging of cells and molecular complexes, genetic analysis of brain development, electrophysiology of ion channels and computational analysis of neurogenetics, neurophysiology and behavior. Trainees leam these approaches for normal brain function and for brain disorders. The program's goal is to prepare students for research careers in Neuroscience with an emphasis on multi-dimensional approaches. With this goal in mind we have assembled a faculty able to direct research projects in behavior, development, biochemistry, electrophysiology, biophysics, molecular biology, photonics, psychophysics, large scale neuronal network analysis, computational neuroscience and brain disease. We have implemented a new core curriculum that encompasses molecular genetics and cell biology, nervous system development, sensorimotor integration and higher brain function and the neurobiology of disease. Our program offers a unique opportunity for students to train in the study of brain function across the phylogenetic spectrum, including in humans in health and disease. We have prepared a series of exams to test our progress in this endeavor and we have mechanisms in place to promote collaborative interactions between the students and the faculty in many departments spanning basic and clinical science. We believe that Predoctoral Training in Neuroscience meets an important national need in modern biomedical and behavioral research, the training of a cadre of students with an integrated understanding across the full spectrum of contemporary molecular, cellular, systems and behavioral neuroscience. Ph.D.students also need to gain a clear appreciation of the many disease-related opportunities in Neuroscience research for which we have added a neurobiology of disease course track along with opportunities for students to interact with patients, learn about animal models of human disease and carry out collaborative and jointly mentored training that spans basic to translational research.
This proposed continuation of Predoctoral Training Program in Neuroscience address a major national health need to train biomedical scientists to carry out cutting edge research on the function, development and diseases of the brain. Trainees learn contemporary molecular, genetic, physiological, behavioral and computational research approaches to brain function in human and animal health and disease.
|Liu, Lucy; MacKenzie, Kevin R; Putluri, Nagireddy et al. (2017) The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D. Cell Metab 26:719-737.e6|
|Chao, Hsiao-Tuan; Liu, Lucy; Bellen, Hugo J (2017) Building dialogues between clinical and biomedical research through cross-species collaborations. Semin Cell Dev Biol 70:49-57|
|Liu, Lucy; Zhang, Ke; Sandoval, Hector et al. (2015) Glial lipid droplets and ROS induced by mitochondrial defects promote neurodegeneration. Cell 160:177-90|
|Tomson, Steffie N; Narayan, Manjari; Allen, Genevera I et al. (2013) Neural networks of colored sequence synesthesia. J Neurosci 33:14098-106|
|Prince, Alison; Pfaffinger, Paul J (2013) Conserved N-terminal negative charges support optimally efficient N-type inactivation of Kv1 channels. PLoS One 8:e62695|
|Nadin, Brian M; Pfaffinger, Paul J (2013) A new TASK for Dipeptidyl Peptidase-like Protein 6. PLoS One 8:e60831|
|Marshall, Kara L; Lumpkin, Ellen A (2012) The molecular basis of mechanosensory transduction. Adv Exp Med Biol 739:142-55|
|Tomson, Steffie N; Avidan, Nili; Lee, Kwanghyuk et al. (2011) The genetics of colored sequence synesthesia: suggestive evidence of linkage to 16q and genetic heterogeneity for the condition. Behav Brain Res 223:48-52|
|Wellnitz, Scott A; Lesniak, Daine R; Gerling, Gregory J et al. (2010) The regularity of sustained firing reveals two populations of slowly adapting touch receptors in mouse hairy skin. J Neurophysiol 103:3378-88|
|Nadin, Brian M; Pfaffinger, Paul J (2010) Dipeptidyl peptidase-like protein 6 is required for normal electrophysiological properties of cerebellar granule cells. J Neurosci 30:8551-65|
Showing the most recent 10 out of 13 publications