Continuing funding is requested to support 8 predoctoral trainees of the Chemistry/Biology Training Program, for the next five-years. The Training Program consists of 27 faculty members from four participating graduate units: Organic Division of the Chemistry Department, Biological Division of the Chemistry Department, Division of Medicinal Chemistry of the College of Pharmacy, and the Ohio State Biochemistry Program (OSBP). The participating faculty members from OSBP are affiliated with many departments and colleges. The research projects of the participating faculty cover four broad areas: Area 1: Synthetic and Medicinal Chemistry;Area 2: Biomolecular Mechanisms and Engineering;Area 3: Structural Biology;and Area 4: Molecular and Cell Biology. The Chemistry/ Biology Training Program is not a separate graduate program. Instead, students will be recruited into the four participating graduate programs and receive training at the chemistry/biology interface. Key elements of the training include monthly luncheon seminars, annual symposia, regular seminars, and the requirement to cover both chemistry and biology disciplines in lab rotations, course work, general exam proposals, and dissertation research. The Executive Committee will evaluate the progress of trainees annually for reappointment. Trainees will attend workshops on Responsible Conduct of Research. Strong effort will be devoted to recruiting and retention of underrepresented minority students and students of disabilities and disadvantaged backgrounds. During the past 9 years, 47 trainees have participated or are still participating in the program;many of the trainees have also been supported by fellowships from the university or other funding agencies. Eighteen trainees have successfully completed the training program and subsequently moved onto permanent positions in academe, government, industry or postdoctoral positions.

Public Health Relevance

The boundary between chemistry and biology has become increasingly blurred. As we strive to understand the biological systems on more fundamental levels, the principles and tools in chemistry become ever more important in biological research. On the other hand, for chemists to have an impact on the biological field, he/she must be armed with a good knowledge of the biological system. The long-term goal of this program is to train students to be ready for such revolutions in fields at the chemistry/biology interface. Our program will continue to produce chemists especially synthetic chemists with significant training in biology, biologists with a greatly enhanced chemistry background (relative to their peers), and chemical biologists who have in-depth training in both areas.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
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National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Fabian, Miles
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Ohio State University
Schools of Arts and Sciences
United States
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Comandur, Roopa; Olson, Erik D; Musier-Forsyth, Karin (2017) Conservation of tRNA mimicry in the 5'-untranslated region of distinct HIV-1 subtypes. RNA 23:1850-1859
Todd, Gabrielle C; Duchon, Alice; Inlora, Jingga et al. (2017) Inhibition of HIV-1 Gag-membrane interactions by specific RNAs. RNA 23:395-405
Li, Jie; Yuan, Chunhua; Pan, Li et al. (2017) Bioassay-Guided Isolation of Antioxidant and Cytoprotective Constituents from a Maqui Berry (Aristotelia chilensis) Dietary Supplement Ingredient As Markers for Qualitative and Quantitative Analysis. J Agric Food Chem 65:8634-8642
Reed, Andrew J; Vyas, Rajan; Raper, Austin T et al. (2017) Structural Insights into the Post-Chemistry Steps of Nucleotide Incorporation Catalyzed by a DNA Polymerase. J Am Chem Soc 139:465-471
Raper, Austin T; Reed, Andrew J; Gadkari, Varun V et al. (2017) Advances in Structural and Single-Molecule Methods for Investigating DNA Lesion Bypass and Repair Polymerases. Chem Res Toxicol 30:260-269
Cantara, William A; Olson, Erik D; Musier-Forsyth, Karin (2017) Analysis of RNA structure using small-angle X-ray scattering. Methods 113:46-55
Danhart, Eric M; Bakhtina, Marina; Cantara, William A et al. (2017) Conformational and chemical selection by a trans-acting editing domain. Proc Natl Acad Sci U S A 114:E6774-E6783
Qian, Ziqing; Rhodes, Curran A; McCroskey, Lucas C et al. (2017) Enhancing the Cell Permeability and Metabolic Stability of Peptidyl Drugs by Reversible Bicyclization. Angew Chem Int Ed Engl 56:1525-1529
Rye-McCurdy, Tiffiny; Olson, Erik D; Liu, Shuohui et al. (2016) Functional Equivalence of Retroviral MA Domains in Facilitating Psi RNA Binding Specificity by Gag. Viruses 8:
Schneider, Camille R; Shafaat, Hannah S (2016) An internal electron reservoir enhances catalytic CO2 reduction by a semisynthetic enzyme. Chem Commun (Camb) 52:9889-92

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