This application requests the third renewal of our Chemistry-Biology Interface (CBI) Training Grant. In 1995 we launched a new interdisciplinary training program at the University of Massachusetts that built on existing strengths and harnessed our faculty commitment to collaboration between the physical and life sciences. We successfully implemented a curriculum that complemented the requirements of the participating graduate programs, adding enough training elements to efficiently train students with either chemical or biological backgrounds in the complementary discipline. The subsequent period (2000-2005) was one of tremendous growth of the program: the number of affiliated students grew from 14 to over 60, as students well beyond those with CBI funding recognized the value of the CBI training and community. During the current funding period our CBI Training Program has become a major force on campus, influencing faculty hiring and construction of new buildings and renovations. The CBI Training Faculty has grown from 19 to 27, and continues to provide cross-training to over 60 students from the four participating graduate programs of Chemistry, Molecular &Cellular Biology, Chemical Engineering, and Polymer Science &Engineering. We anticipate continued growth of our CBI Program as additional departments (notably Physics and Computer Science) move into CBI- related areas. The CBI Program currently provides NIH support for 6 pre-doctoral students, and a University match supports 2 additional Traineeships. To continue to foster the growing strength of the CBI program as it expands into new disciplines and trains increasing numbers of students, we request an increase to 8 NIH-funded Traineeships. Notable features of our CBI Program include the participation of the Departments of Chemical Engineering and Polymer Science &Engineering, which enriches CBI training with quantitative, biomaterials, and bioengineering perspectives and projects. Our popular """"""""Drug Design"""""""" course, developed as an integral part of the CBI curriculum, features weekly seminars by speakers from the pharmaceutical industry and a field trip to tour a company. Our CBI retreat has grown into a vibrant annual event that forges connections with researchers at UMass Medical School. Finally, CBI students, in partnership with students of the new UMass Institute for Cellular Engineering, are organizing a new annual Career Day to further enhance their CBI training. Thus the CBI curriculum and community are rich in opportunities for training in the methods and intellectual framework of both chemistry and biology, which prepares our CBI graduates to pose and solve significant biomedical questions in their future work.

Public Health Relevance

Understanding the causes of a disease and developing new treatments requires scientists to apply the concepts and methods of both chemistry and biology. Graduate students pursuing the Ph.D. in either chemical or biological sciences at UMass have the opportunity to be trained in the complementary discipline through the curriculum and interactions of the Chemistry-Biology Interface (CBI) Training Program. This training prepares them for productive careers in the biomedical sciences in industrial, academic, or governmental laboratories.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
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National Institute of General Medical Sciences Initial Review Group (BRT)
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Fabian, Miles
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University of Massachusetts Amherst
Schools of Arts and Sciences
United States
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Caffrey, Leah M; deRonde, Brittany M; Minter, Lisa M et al. (2016) Mapping Optimal Charge Density and Length of ROMP-Based PTDMs for siRNA Internalization. Biomacromolecules 17:3205-3212
Romano, Fabian B; Tang, Yuzhou; Rossi, Kyle C et al. (2016) Type 3 Secretion Translocators Spontaneously Assemble a Hexadecameric Transmembrane Complex. J Biol Chem 291:6304-15
Taabazuing, Cornelius Y; Fermann, Justin; Garman, Scott et al. (2016) Substrate Promotes Productive Gas Binding in the α-Ketoglutarate-Dependent Oxygenase FIH. Biochemistry 55:277-86
Chang, Chia-Chih; Kolewe, Kristopher W; Li, Yinyong et al. (2016) Underwater Superoleophobic Surfaces Prepared from Polymer Zwitterion/Dopamine Composite Coatings. Adv Mater Interfaces 3:
Barney, L E; Jansen, L E; Polio, S R et al. (2016) The Predictive Link between Matrix and Metastasis. Curr Opin Chem Eng 11:85-93
Backlund, Coralie M; Takeuchi, Toshihide; Futaki, Shiroh et al. (2016) Relating structure and internalization for ROMP-based protein mimics. Biochim Biophys Acta 1858:1443-50
Jiang, Ying; Wang, Ming; Hardie, Joseph et al. (2016) Chemically Engineered Nanoparticle-Protein Interface for Real-Time Cellular Oxidative Stress Monitoring. Small 12:3775-9
Guerra, Damian; Ballard, Keith; Truebridge, Ian et al. (2016) S-Nitrosation of Conserved Cysteines Modulates Activity and Stability of S-Nitrosoglutathione Reductase (GSNOR). Biochemistry 55:2452-64
Kolewe, Kristopher W; Dobosz, Kerianne M; Rieger, Katrina A et al. (2016) Antifouling Electrospun Nanofiber Mats Functionalized with Polymer Zwitterions. ACS Appl Mater Interfaces :
Yoshii, Tatsuyuki; Geng, Yingying; Peyton, Shelly et al. (2016) Biochemical and biomechanical drivers of cancer cell metastasis, drug response and nanomedicine. Drug Discov Today 21:1489-94

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