This T32 Trauma Training Program is designed to train surgical residents in the fundamentals of basic research. This is accomplished using a training committee comprised of a principal trainer and a team of associate trainers in a closely supervised training program. The training scheme is based on weekly interactions between the training committee and the trainee in the form of twice weekly training research sessions. The trauma research program is integrated into a department-wide (Surgery) surgeon-scientist training program where all residents in the General Surgery Training Program participate in a two or three year curriculum designed to provide research training. A tract to obtain a Ph.D. through the Department of Pharmacology is available for trainees who commit to three years of training. Funding for five positions is sought to support trainees who enter the program after two or three years of surgical residency. A few Ph.D. post-docs will be accepted as well. The research areas are all based on trauma and its consequences. Much of the research is supported by a P50 Trauma Center Grant entitled """"""""The Molecular Biology of Hemorrhagic Shock"""""""". Understanding the regulation and consequences of trauma-induced inflammation is at the core of much of the research training. The program introduces systems biology concepts in the training as well as opportunities in regenerative medicine relevant to trauma research. Relevance: Trauma is the most common cause of death and morbidity for people under the age of 50 years. Progress in reducing the death rate and serious complications that occur after injury requires individuals trained not only in the clinical care of surgical patients, but also the fundamentals of basic research. This training program is designed to prepare surgeons to identify the appropriate research questions and equip these clinician investigators with the skills needed to provide the answers for the benefit of trauma patients.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008516-18
Application #
8104093
Study Section
Special Emphasis Panel (ZGM1-BRT-5 (PD))
Program Officer
Somers, Scott D
Project Start
1994-07-01
Project End
2014-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
18
Fiscal Year
2011
Total Cost
$292,782
Indirect Cost
Name
University of Pittsburgh
Department
Surgery
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Brown, Joshua B; Gestring, Mark L; Leeper, Christine M et al. (2017) The value of the injury severity score in pediatric trauma: Time for a new definition of severe injury? J Trauma Acute Care Surg 82:995-1001
Brown, Joshua B; Rosengart, Matthew R; Billiar, Timothy R et al. (2017) Distance matters: Effect of geographic trauma system resource organization on fatal motor vehicle collisions. J Trauma Acute Care Surg 83:111-118
Zettel, Kent R; Dyer, Mitchell; Raval, Jay S et al. (2017) Aged Human Stored Red Blood Cell Supernatant Inhibits Macrophage Phagocytosis in an HMGB1 Dependent Manner After Trauma in a Murine Model. Shock 47:217-224
Zhang, Xianghong; Yuan, Du; Sun, Qian et al. (2017) Calcium/calmodulin-dependent protein kinase regulates the PINK1/Parkin and DJ-1 pathways of mitophagy during sepsis. FASEB J 31:4382-4395
Lewis, Anthony; Zuckerbraun, Brian; Griepentrog, John et al. (2017) Reducing Animal Use with a Biotelemetry-Enhanced Murine Model of Sepsis. Sci Rep 7:6622
Xu, Jing; Guardado, Jesse; Hoffman, Rosemary et al. (2017) IL33-mediated ILC2 activation and neutrophil IL5 production in the lung response after severe trauma: A reverse translation study from a human cohort to a mouse trauma model. PLoS Med 14:e1002365
Shukla, M; Sekhon, U D S; Betapudi, V et al. (2017) In vitro characterization of SynthoPlate™ (synthetic platelet) technology and its in vivo evaluation in severely thrombocytopenic mice. J Thromb Haemost 15:375-387
Brown, Joshua B; Gestring, Mark L; Guyette, Francis X et al. (2017) External validation of the Air Medical Prehospital Triage score for identifying trauma patients likely to benefit from scene helicopter transport. J Trauma Acute Care Surg 82:270-279
Brown, Joshua B; Gestring, Mark L; Guyette, Francis X et al. (2016) Development and Validation of the Air Medical Prehospital Triage Score for Helicopter Transport of Trauma Patients. Ann Surg 264:378-85
Lewis, Anthony J; Yuan, Du; Zhang, Xianghong et al. (2016) Use of Biotelemetry to Define Physiology-Based Deterioration Thresholds in a Murine Cecal Ligation and Puncture Model of Sepsis. Crit Care Med 44:e420-31

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