The predoctoral Program in Biomolecular Pharmacology at Boston University School of Medicine was initiated in 1990 and received this NIGMS Institutional Training Grant in 1997. In the ensuing ten years of NIGMS support, this university-wide program has flourished, providing a unique learning environment for doctoral students that combines an innovative curriculum, interdisciplinary laboratory rotations, and expanded opportunities for thesis research by bridging multiple departments across Boston University's two campuses. Students enter the program from one of three academic units: Pharmacology and Experimental Therapeutics (PET), Biomedical Engineering (BME), and Molecular Medicine (MM). Program trainees in BME and MM experience an integrated curriculum designed to provide enriched training in pharmacology that is coordinated with specialized training in their discipline while trainees in PET gain access to diverse research and educational experiences that build upon those provided by core pharmacology faculty. The curriculum stresses fundamental pharmacologic principles as well as key issues governing interactions of bioactive molecules, challenges of drug delivery for novel therapeutics, animal models and their relevance to the clinic, and the challenges for modern drug discovery. Participating faculty, originally fifteen and now forty-six, contribute expertise in focus areas including neuropharmacology, vascular and cancer pharmacology, genomics, proteomics, animal models (transgenic and behavioral), structural biology, and DMA, RNA, and protein chemistry. Sites for thesis research are also located in departments of Chemistry, Biology, Psychology, Neurology and Psychiatry. A summer internship with collaborating scientists at Wyeth Research has been fully implemented and career guidance and mentorship/leadership opportunities engage trainees with quality experiences that are relevant to their future careers in pharmacology both in academia and industry. Since inception, forty-two students have been supported by this NIGMS program that was one of the first to provide an interface for quantitatively trained BME students to link their core studies with training in pharmacological sciences. The program has continued this mission and expanded to position students with intellectual tools needed to advance drug discovery, medicine, and the future of global health by training the next generation of leaders equipped to translate basic research advances into medications.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Okita, Richard T
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Boston University
Schools of Medicine
United States
Zip Code
Kirkpatrick, Stacey L; Goldberg, Lisa R; Yazdani, Neema et al. (2017) Cytoplasmic FMR1-Interacting Protein 2 Is a Major Genetic Factor Underlying Binge Eating. Biol Psychiatry 81:757-769
Estrada, Larissa I; Robinson, Amy A; Amaral, Ana C et al. (2017) Evaluation of Long-Term Cryostorage of Brain Tissue Sections for Quantitative Histochemistry. J Histochem Cytochem 65:153-171
Varnum, Megan M; Clayton, Kevin A; Yoshii-Kitahara, Asuka et al. (2017) A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells. J Biol Chem 292:10651-10663
Grant, Trevor J; Mehta, Anita K; Gupta, Anamika et al. (2017) STK38L kinase ablation promotes loss of cell viability in a subset of KRAS-dependent pancreatic cancer cell lines. Oncotarget 8:78556-78572
Clayton, Kevin A; Van Enoo, Alicia A; Ikezu, Tsuneya (2017) Alzheimer's Disease: The Role of Microglia in Brain Homeostasis and Proteopathy. Front Neurosci 11:680
Weinstein, Zohar B; Zaman, Muhammad H (2017) Quantitative bioassay to identify antimicrobial drugs through drug interaction fingerprint analysis. Sci Rep 7:42644
Mehta, Anita K; Hua, Kevin; Whipple, William et al. (2017) Regulation of autophagy, NF-?B signaling, and cell viability by miR-124 in KRAS mutant mesenchymal-like NSCLC cells. Sci Signal 10:
Lakin, Benjamin A; Patel, Harsh; Holland, Conor et al. (2016) Contrast-enhanced CT using a cationic contrast agent enables non-destructive assessment of the biochemical and biomechanical properties of mouse tibial plateau cartilage. J Orthop Res 34:1130-8
Frame, Alissa A; Carmichael, Casey Y; Wainford, Richard D (2016) Renal Afferents. Curr Hypertens Rep 18:69
Walsh, Kathryn R; Kuwabara, Jill T; Shim, Joon W et al. (2016) Norepinephrine-evoked salt-sensitive hypertension requires impaired renal sodium chloride cotransporter activity in Sprague-Dawley rats. Am J Physiol Regul Integr Comp Physiol 310:R115-24

Showing the most recent 10 out of 109 publications