The doctoral training program in the Dynamic Aspects of Chemical Biology at the University of Kansas (KU) aims to educate doctoral graduates across the chemistry biology interface. Students in the chemical sciences will develop a working knowledge biological information and skills. The converse will also be true: students in the biological sciences will graduate with a command of chemistry. This training program takes advantage of a local tradition of over 50 years of close and effective collaboration among scientists at the interface of chemistry, biology, and the pharmaceutical sciences. Participating faculty from the Departments of Chemistry, Medicinal Chemistry, Molecular Biosciences and Pharmaceutical Chemistry are connected by a common theme of probing biological systems with small molecules. At the heart of this training program is the proposed establishment of an integrated academic curriculum and seminar series that will serve the broader Chemical Biology community at KU. In order to meet this goal, our competitive renewal application proposes (1) a revised curriculum including two new courses in chemical biology required by trainees and available to the broader community at KU; (2) a new Graduate Certificate in Chemical Biology available to all graduate students in the affiliated departments; (3) a vibrant seminar series that spans all four departments and provides instruction on different careers in chemical biology; (4) a collaborative rotation that provides participating trainees with the background for attaining a working knowledge of the key concepts and methods of the training goal; and (5) continued training in the responsible conduct of research. Trainees will reap the benefits of collaborative exposure to modern experimental techniques and theories in disciplines across the chemical biology interface and will be fully prepared to meet the challenges of contemporary chemical biology.

Public Health Relevance

At the heart of this proposal is the establishment of an integrated training program in the dynamic aspects of chemical biology. Integrated approaches that foster collaboration across scientific disciplines are paramount to gaining a broader understanding at the chemical biology interface with the ultimate goal of improving human health. Training and student projects span a wide array of disease states and health issues, including cancer, diabetes, heart disease, pathogenic microbes and antimicrobials/antibiotics, Alzheimer's and Parkinson's disease, and addiction, to name only a few.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008545-23
Application #
9068148
Study Section
Training and Workforce Development Subcommittee - D (TWD)
Program Officer
Fabian, Miles
Project Start
1994-07-01
Project End
2020-06-30
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
23
Fiscal Year
2016
Total Cost
Indirect Cost
Name
University of Kansas Lawrence
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
076248616
City
Lawrence
State
KS
Country
United States
Zip Code
66045
Pickens, Chad J; Johnson, Stephanie N; Pressnall, Melissa M et al. (2018) Practical Considerations, Challenges, and Limitations of Bioconjugation via Azide-Alkyne Cycloaddition. Bioconjug Chem 29:686-701
McFarlane, Jeffrey S; Davis, Cara L; Lamb, Audrey L (2018) Staphylopine, pseudopaline, and yersinopine dehydrogenases: A structural and kinetic analysis of a new functional class of opine dehydrogenase. J Biol Chem 293:8009-8019
Bart, Aaron G; Scott, Emily E (2018) Structures of human cytochrome P450 1A1 with bergamottin and erlotinib reveal active-site modifications for binding of diverse ligands. J Biol Chem 293:19201-19210
Khandelwal, Anuj; Kent, Caitlin N; Balch, Maurie et al. (2018) Structure-guided design of an Hsp90? N-terminal isoform-selective inhibitor. Nat Commun 9:425
Mori-Quiroz, Luis M; Hedrick, Sidnee L; De Los Santos, Andrew R et al. (2018) A Unified Strategy for the Syntheses of the Isoquinolinium Alkaloids Berberine, Coptisine, and Jatrorrhizine. Org Lett 20:4281-4284
Ronnebaum, Trey A; Lamb, Audrey L (2018) Nonribosomal peptides for iron acquisition: pyochelin biosynthesis as a case study. Curr Opin Struct Biol 53:1-11
Sherwood, Alexander M; Williamson, Samuel E; Johnson, Stephanie N et al. (2018) Scalable Regioselective and Stereoselective Synthesis of Functionalized (E)-4-Iodobut-3-en-1-ols: Gram-Scale Total Synthesis of Fungal Decanolides and Derivatives. J Org Chem 83:980-992
Shin, Inchul; Ambler, Brett R; Wherritt, Daniel et al. (2018) Stepwise O-Atom Transfer in Heme-Based Tryptophan Dioxygenase: Role of Substrate Ammonium in Epoxide Ring Opening. J Am Chem Soc 140:4372-4379
Evans, Kara C; Benomar, Saida; Camuy-VĂ©lez, Lennel A et al. (2018) Quorum-sensing control of antibiotic resistance stabilizes cooperation in Chromobacterium violaceum. ISME J 12:1263-1272
Zhou, Yan; Crowley, Rachel; Prisinzano, Thomas et al. (2018) Effects of mesyl salvinorin B alone and in combination with naltrexone on alcohol deprivation effect in male and female mice. Neurosci Lett 673:19-23

Showing the most recent 10 out of 120 publications