The goal of this Chemistry-Biology Interface (CBI) Predoctoral Program is to provide multidisciplinary education for a talented group of students to enable them to apply the mechanistic and synthetic approaches of chemistry to important biological problems. This Program involves outstanding faculty members from six academic units at the University of Delaware, who represent the diverse disciplines of biochemistry, biochemical engineering, bioorganic chemistry, molecular biology, cell biology, virology, bioanalytical chemistry, structural biology, bioinorganic chemistry and plant biochemistry. The faculty trainers, all of whom have active research programs, represent a mixture of promising new investigators and established scientists experienced in educating graduate students. Trainees will be selected from a pool of superior students with varied undergraduate backgrounds, on the basis of GRE scores, grade point averages, recommendation letters, prior research experience and personal interviews. Students will be admitted into the existing graduate programs in Chemistry and Biochemistry, in Chemical Engineering or in Biological Sciences and will satisfy the requirements for the Chemistry-Biology Interface Program, as well as for the relevant departmental program. The CBI Program will feature laboratory rotations to facilitate exposure of each student to a variety of research areas. At least 5 one-semester courses (which can also be used toward meeting the departmental requirements) will be selected from a broad range of graduate courses in six departments. A course on Scientific Integrity and Ethical Principles in Research, and a multidisciplinary CBI seminar will also be required, in addition to attendance at more specialized seminars within sub-disciplines of the participating departments. An intense research experience will culminate in a dissertation which presents a significant original contribution to a field at the interface of chemistry and biology. The progress of students will be closely monitored by the faculty. As a result of this graduate program, students will acquire a broad background in the fundamentals of biochemistry, chemistry and molecular biology, as well as detailed expertise in the specific area of their research project. This training will equip them to be leaders in the biotechnology and pharmaceutical industries, or in academic institutions in Chemistry, Medicinal Chemistry, Biochemistry, Biology, Bioengineering, Molecular Biology, or Pharmacology Departments. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008550-15
Application #
7455144
Study Section
Special Emphasis Panel (ZGM1-BRT-0 (04))
Program Officer
Rogers, Michael E
Project Start
1994-07-01
Project End
2009-06-30
Budget Start
2008-07-01
Budget End
2009-06-30
Support Year
15
Fiscal Year
2008
Total Cost
$235,384
Indirect Cost
Name
University of Delaware
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
059007500
City
Newark
State
DE
Country
United States
Zip Code
19716
Smith, Natalee J; Rohlfing, Katarina; Sawicki, Lisa A et al. (2018) Fast, irreversible modification of cysteines through strain releasing conjugate additions of cyclopropenyl ketones. Org Biomol Chem 16:2164-2169
DeMeester, Kristen E; Liang, Hai; Jensen, Matthew R et al. (2018) Synthesis of Functionalized N-Acetyl Muramic Acids To Probe Bacterial Cell Wall Recycling and Biosynthesis. J Am Chem Soc 140:9458-9465
Drake, Walter R; Hou, Ching-Wen; Zachara, Natasha E et al. (2018) New use for CETSA: monitoring innate immune receptor stability via post-translational modification by OGT. J Bioenerg Biomembr 50:231-240
Lu, Manman; Sarkar, Sucharita; Wang, Mingzhang et al. (2018) 19F Magic Angle Spinning NMR Spectroscopy and Density Functional Theory Calculations of Fluorosubstituted Tryptophans: Integrating Experiment and Theory for Accurate Determination of Chemical Shift Tensors. J Phys Chem B 122:6148-6155
Liu, Jun; Chen, Qingqing; Rozovsky, Sharon (2018) Selenocysteine-Mediated Expressed Protein Ligation of SELENOM. Methods Mol Biol 1661:265-283
Franke, Karl R; Schmidt, Skye A; Park, Sunhee et al. (2018) Analysis of Brachypodium miRNA targets: evidence for diverse control during stress and conservation in bioenergy crops. BMC Genomics 19:547
Chiu, Josephine; Valente, Kristin N; Levy, Nicholas E et al. (2017) Knockout of a difficult-to-remove CHO host cell protein, lipoprotein lipase, for improved polysorbate stability in monoclonal antibody formulations. Biotechnol Bioeng 114:1006-1015
Long, Christopher P; Gonzalez, Jacqueline E; Feist, Adam M et al. (2017) Fast growth phenotype of E. coli K-12 from adaptive laboratory evolution does not require intracellular flux rewiring. Metab Eng 44:100-107
Luo, Tianzhi; David, Michael A; Dunshee, Lucas C et al. (2017) Thermoresponsive Elastin-b-Collagen-Like Peptide Bioconjugate Nanovesicles for Targeted Drug Delivery to Collagen-Containing Matrices. Biomacromolecules 18:2539-2551
Wang, Yiben; Lazor, Klare M; DeMeester, Kristen E et al. (2017) Postsynthetic Modification of Bacterial Peptidoglycan Using Bioorthogonal N-Acetylcysteamine Analogs and Peptidoglycan O-Acetyltransferase B. J Am Chem Soc 139:13596-13599

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