This proposal is a resubmission requesting continuing support for the Cellular, Biochemical, and Molecular Sciences (CBMS) training program at Vanderbilt University. Over the 15 years of the CBMS training program at Vanderbilt and continuing with the 5-year period preceding this competitive renewal, we have been remarkably successful recruiting excellent students, particularly students from groups underrepresented in science. Extensive institutional support and commitment along with a number of administrative and programmatic initiatives over the past years have contributed to this success and bode well for continuing success. Overall, the CBMS training program encompasses a group of ~80 faculty from biomedical research departments and programs at Vanderbilt that has trained 70 students including 9 current trainees. High caliber trainees are recruited as part of the Vanderbilt Interdisciplinary Graduate Program (IGP) and undergo broad didactic interdisciplinary training in CBMS target areas, rigorous elective courses for specialized training, a weekly journal club meeting, weekly mentoring and training sessions, an annual research retreat, continuing training in Responsible Conduct in Research and, most importantly, in depth, laboratory research experience.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
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National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Gindhart, Joseph G
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Vanderbilt University Medical Center
Schools of Medicine
United States
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Chaturvedi, R; de Sablet, T; Asim, M et al. (2015) Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase. Oncogene 34:3429-40
Krakowiak, M S; Noto, J M; Piazuelo, M B et al. (2015) Matrix metalloproteinase 7 restrains Helicobacter pylori-induced gastric inflammation and premalignant lesions in the stomach by altering macrophage polarization. Oncogene 34:1865-71
Adams, Clare M; Eischen, Christine M (2014) Inactivation of p53 is insufficient to allow B cells and B-cell lymphomas to survive without Dicer. Cancer Res 74:3923-34
Niu, Xubo; Hong, Jian; Zheng, Xiaofeng et al. (2014) The nuclear pore complex function of Sec13 protein is required for cell survival during retinal development. J Biol Chem 289:11971-85
Shifrin Jr, David A; Crawley, Scott W; Grega-Larson, Nathan E et al. (2014) Dynamics of brush border remodeling induced by enteropathogenic E. coli. Gut Microbes 5:504-16
Palmer, Trenis D; Martinez, Carlos H; Vasquez, Catalina et al. (2014) Integrin-free tetraspanin CD151 can inhibit tumor cell motility upon clustering and is a clinical indicator of prostate cancer progression. Cancer Res 74:173-87
Hainline, Sarah G; Rickmyre, Jamie L; Neitzel, Leif R et al. (2014) The Drosophila MCPH1-B isoform is a substrate of the APCCdh1 E3 ubiquitin ligase complex. Biol Open 3:669-76
Rachfall, Nicole; Johnson, Alyssa E; Mehta, Sapna et al. (2014) Cdk1 promotes cytokinesis in fission yeast through activation of the septation initiation network. Mol Biol Cell 25:2250-9
Mazalouskas, Matthew D; Godoy-Ruiz, Raquel; Weber, David J et al. (2014) Small G proteins Rac1 and Ras regulate serine/threonine protein phosphatase 5 (PP5)ýýextracellular signal-regulated kinase (ERK) complexes involved in the feedback regulation of Raf1. J Biol Chem 289:4219-32
Crawley, Scott W; Shifrin Jr, David A; Grega-Larson, Nathan E et al. (2014) Intestinal brush border assembly driven by protocadherin-based intermicrovillar adhesion. Cell 157:433-46

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